Sentences with phrase «for cellular homeostasis»

Autophagy is a self - degradative process for cellular homeostasis.

Not exact matches

Recently, researchers have begun to describe the function of autophagy, a cellular recycling process critical for homeostasis, in germline stem - cell proliferation of C. elegans.

Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity.

Fusion of biological membranes is an essential process required for basic functions like transport of material within the cell, maintenance of cellular homeostasis and communication between cells.

For setting cancer in the context of ageing tissue, study of normal adult homeostasis is important — we are studying mutational processes, clonal dynamics and cellular competition in thousands of non-cancerous cells and samples from a range of tissue types, in health and disease.

The goals of this initiative are to understand cellular and molecular processes required for brain homeostasis and to identify deficiencies in neurological and neurodegenerative disease.

In the case of cellular amino acid homeostasis, many examples will be drawn from cancer cells, for which the understanding is more complete than for other cell types.

Deciphering the prevalence and functional impact of this post-transcriptional control layer requires technologies for disrupting RREs without perturbing cellular homeostasis.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

The microRNA miR - 181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.

These extra calories are used for cellular repair, re-oxygenating the blood, and many other functions to bring the body back to homeostasis.

At any given time, the liver is releasing a constant supply of amino acids to skeletal muscle for maintaining blood sugar levels and supporting cellular protein homeostasis.