Sentences with phrase «for changes in the cycle»

The main reason for changes in the cycle and more rapid melting can be attributed to anthropogenic forcings.

Not exact matches

Used both along roadways and in stores, these billboards allow for an ever - changing and instantly updated cycle of information.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Factors that could cause or contribute to actual results differing from our forward - looking statements include risks relating to: failure of DBRS to rate the Notes at the anticipated ratings levels, which is a closing condition, or at all; changes in the financial markets, including changes in credit markets, interest rates, securitization markets generally and our proposed securitization in particular; the willingness of investors to buy the Notes; adverse developments regarding OnDeck, its business or the online or broader marketplace lending industry generally, any of which could impact what credit ratings, if any, are issued with respect to the Notes; the extended settlement cycle for the scheduled closing on April 17, 2018, which may exacerbate the foregoing risks; and other risks, including those described in our Annual Report on Form 10 - K for the year ended December 31, 2017 and in other documents that we file with the Securities and Exchange Commission from time to time which are or will be available on the Commission's website at www.sec.gov.

[16:00] Pain + reflection = progress [16:30] Creating a meritocracy to draw the best out of everybody [18:30] How to raise your probability of being right [18:50] Why we are conditioned to need to be right [19:30] The neuroscience factor [19:50] The habitual and environmental factor [20:20] How to get to the other side [21:20] Great collective decision - making [21:50] The 5 things you need to be successful [21:55] Create audacious goals [22:15] Why you need problems [22:25] Diagnose the problems to determine the root causes [22:50] Determine the design for what you will do about the root causes [23:00] Decide to work with people who are strong where you are weak [23:15] Push through to results [23:20] The loop of success [24:15] Ray's new instinctual approach to failure [24:40] Tony's ritual after every event [25:30] The review that changed Ray's outlook on leadership [27:30] Creating new policies based on fairness and truth [28:00] What people are missing about Ray's culture [29:30] Creating meaningful work and meaningful relationships [30:15] The importance of radical honesty [30:50] Thoughtful disagreement [32:10] Why it was the relationships that changed Ray's life [33:10] Ray's biggest weakness and how he overcame it [34:30] The jungle metaphor [36:00] The dot collector — deciding what to listen to [40:15] The wanting of meritocratic decision - making [41:40] How to see bubbles and busts [42:40] Productivity [43:00] Where we are in the cycle [43:40] What the Fed will do [44:05] We are late in the long - term debt cycle [44:30] Long - term debt is going to be squeezing us [45:00] We have 2 economies [45:30] This year is very similar to 1937 [46:10] The top tenth of the top 1 % of wealth = bottom 90 % combined [46:25] How this creates populism [47:00] The economy for the bottom 60 % isn't growing [48:20] If you look at averages, the country is in a bind [49:10] What are the overarching principles that bind us together?

BlackBerry's ability to manage inventory and asset risk; BlackBerry's reliance on suppliers of functional components for its products and risks relating to its supply chain; BlackBerry's ability to obtain rights to use software or components supplied by third parties; BlackBerry's ability to successfully maintain and enhance its brand; risks related to government regulations, including regulations relating to encryption technology; BlackBerry's ability to continue to adapt to recent board and management changes and headcount reductions; reliance on strategic alliances with third - party network infrastructure developers, software platform vendors and service platform vendors; BlackBerry's reliance on third - party manufacturers; potential defects and vulnerabilities in BlackBerry's products; risks related to litigation, including litigation claims arising from BlackBerry's practice of providing forward - looking guidance; potential charges relating to the impairment of intangible assets recorded on BlackBerry's balance sheet; risks as a result of actions of activist shareholders; government regulation of wireless spectrum and radio frequencies; risks related to economic and geopolitical conditions; risks associated with acquisitions; foreign exchange risks; and difficulties in forecasting BlackBerry's financial results given the rapid technological changes, evolving industry standards, intense competition and short product life cycles that characterize the wireless communications industry, and the company's previously disclosed review of strategic alternatives.

Many factors could cause BlackBerry's actual results, performance or achievements to differ materially from those expressed or implied by the forward - looking statements, including, without limitation: BlackBerry's ability to enhance its current products and services, or develop new products and services in a timely manner or at competitive prices, including risks related to new product introductions; risks related to BlackBerry's ability to mitigate the impact of the anticipated decline in BlackBerry's infrastructure access fees on its consolidated revenue by developing an integrated services and software offering; intense competition, rapid change and significant strategic alliances within BlackBerry's industry; BlackBerry's reliance on carrier partners and distributors; risks associated with BlackBerry's foreign operations, including risks related to recent political and economic developments in Venezuela and the impact of foreign currency restrictions; risks relating to network disruptions and other business interruptions, including costs, potential liabilities, lost revenues and reputational damage associated with service interruptions; risks related to BlackBerry's ability to implement and to realize the anticipated benefits of its CORE program; BlackBerry's ability to maintain or increase its cash balance; security risks; BlackBerry's ability to attract and retain key personnel; risks related to intellectual property rights; BlackBerry's ability to expand and manage BlackBerry ® World ™; risks related to the collection, storage, transmission, use and disclosure of confidential and personal information; BlackBerry's ability to manage inventory and asset risk; BlackBerry's reliance on suppliers of functional components for its products and risks relating to its supply chain; BlackBerry's ability to obtain rights to use software or components supplied by third parties; BlackBerry's ability to successfully maintain and enhance its brand; risks related to government regulations, including regulations relating to encryption technology; BlackBerry's ability to continue to adapt to recent board and management changes and headcount reductions; reliance on strategic alliances with third - party network infrastructure developers, software platform vendors and service platform vendors; BlackBerry's reliance on third - party manufacturers; potential defects and vulnerabilities in BlackBerry's products; risks related to litigation, including litigation claims arising from BlackBerry's practice of providing forward - looking guidance; potential charges relating to the impairment of intangible assets recorded on BlackBerry's balance sheet; risks as a result of actions of activist shareholders; government regulation of wireless spectrum and radio frequencies; risks related to economic and geopolitical conditions; risks associated with acquisitions; foreign exchange risks; and difficulties in forecasting BlackBerry's financial results given the rapid technological changes, evolving industry standards, intense competition and short product life cycles that characterize the wireless communications industry.

This might not be a groundbreaking change — maybe you're moving from $ 40,000 to $ 60,000 in financing, for example, or from a loan term of 18 to 24 months — but you're still expanding your possibilities for growth, building credit, and keeping the financing cycle going.

The great victory of the Federal Reserve in the half - cycle since 2009 was not ending the global financial crisis; the crisis actually ended in March 2009 with the stroke of a pen that changed accounting rule FAS157 and eliminated mark - to - market accounting for banks (instantly removing the specter of widespread insolvencies by allowing «significant judgment» in valuing distressed assets).

We're always open to evidence that would change our analysis of very long - term growth prospects for the U.S. economy, but that evidence evolves slowly enough that we could easily see another complete bull - bear cycle in the interim.

Right now Abra is one wallet / one currency but we give you the ability to do a foreign currency conversion right in the app so you can change your currency any time you like (you do have to wait at least one block cycle for the exchange to settle.)

The changes occurring in today's high - yield markets, however, indicate that history may not be a perfect guide for investors over the next credit cycle.

Then arrived JOBS Act and brought along CrowdInvesting, the exchange of securities for an investment and it became evident that the role of angel investing and venture capital was about to change; not that it will be eliminated but might get reduced and move later in the cycle of fund raising i.e., beyond Seed round or Series A.

It also doesn't help that the narrative for active management is constantly changing over time depending on where we are in the investment cycle.

In all this, we make allowance as best we can for the state of the business cycle, and for structural changes which may be affecting the course of these variables.

It makes explicit use of a number of types of indicators in the company's share price graph, looking for cycles, patterns and sentiment changes to determine the suitability of a trade.

However, total factor productivity, which allows for changes in both labour and capital inputs into the production process, and is therefore a better measure of efficiency, is growing faster in the current recovery than in the corresponding phases of either of the two previous cycles (Box 2).

Given that the underlying fundamentals have only changed for the better, a more sustained rally in crypto assets could strengthen portfolios struggling with the late - cycle blues.

Be mindful that a shift in market internals doesn't necessarily mean that the entire cycle has changed from bull to bear or vice versa, so we always have to allow for shifts.

The central message of our discipline is that valuations are enormously informative about prospects for long - term and full - cycle returns, but that outcomes over shorter segments of the market cycle are driven by changes in the psychological preferences of investors toward speculation or risk - aversion.

The underlying assumption behind all the models in this chapter is that a congregation has an exciting possibility and responsibility to create a comprehensive marriage and family nurture program, beginning with remote preparation for marriage and extending through all the changing seasons of the life cycle of a family.

what is necessary and a very important change for us today and the future is our conscience, and this requires global consciousness necessary for our long term needs and survival, we need a faith that will compel us to unite to address the problems of survival, in the future, a few thousand years from now the glacial period cycle is due, earth will no longer be hospitable and we either have to immigrate to other planets or, develope a system that will protect us, the natural calamities like floods, typhoons, sub zero temperatures, will become our big problem in the future, so we need a religion that will guide our conscience from simplistic self survival towards a more holistic view of reality.Our oneness with ourselves and Him is the primary tenets or doctrines of this religion.

For this unintelligent substance to remain in perfect cyclical motion perpetually it is impossible that there would ever be a difference from one cycle to the next (and no possible cause for change) Therefore, in this version of existence there is no possibility for an unexpected change in the motion of existenFor this unintelligent substance to remain in perfect cyclical motion perpetually it is impossible that there would ever be a difference from one cycle to the next (and no possible cause for change) Therefore, in this version of existence there is no possibility for an unexpected change in the motion of existenfor change) Therefore, in this version of existence there is no possibility for an unexpected change in the motion of existenfor an unexpected change in the motion of existence.

Are they using the Julian calendar, the Gregorian calendar, the Christian calendar, the Jewish calendar, and have they corrected for all the various changes in the solar system cycles since any of the calendars began to be used.

Sometimes the company will be able to price a new product early in the development cycle only to see prices for ingredients change dramatically before the product is ever ready for stores.

I am on a ketogenic diet from last 9 days but no change in my weight.I also walk briskly for an hour on treadmill and cycle apart from some exercises.i take three meals in d day comprising of eggs (2) and cottage cheese in the morning with green tea with coconut milk, Red meat 2pieces or chicken with tomatoes or spinach cooked in olive oil in lunch and egg scramble and 1 piece of meat in evening.please suggest me what should I do to go into ketosis immediately

* Only change that I made (I like the crust better using a glass loaf pan and the oven) use the dough cycle, remove from machine, roll in generous amount of corn meal, spray a loaf with Pam, dust with cornmeal, cover with warm towel, let rise for about an hour, bake as usual.

We wrote about some of the budget cards to look for earlier in the game's cycle, but auction house prices have changed significantly, and now 2K has released tons of new cards, both from new series and from the Historic collections.

As much as I appreciate what Wenger has done for the club, I would also appreciate it if he wasn't in charge next season, it's nothing personal I just feel that after the period of transition we have flat - lined and the truth is whether it be tactics, injuries, personal recruitment that have been contributing factors to us not being able to win the Premier league title... it's all on him and until we change manager this stupid cycle will persist... Eddie D

You might also miss a period if you have a change in your sleep patterns, for example, you start working night shifts and sometimes that can throw your cycles out of whack and make your period wonky for a bit as your body adjusts to it.

Watch your little one for signs of hunger, such as sucking sounds and / or lip movements, rapid eye movement during the light sleep cycle and changes in facial expression.

When we talk about the potential for Attachment Parenting (AP) to change the world, we are referring to a ripple effect: Our children growing up to be compassionate and empathic, becoming parents who foster secure attachments with their children, whose children then grow up to repeat the cycle of peaceful living both in and out of the home.

You can also track subtle changes in your basal body temperature (BBT), cervical mucus, and cervical firmness for a few cycles to try to determine when you ovulate.

You can catch hormonal imbalances before they become serious, notice even the slightest changes in your cycle and health so you can be prepared for changes in your body before they happen, and even detect issues (like cervical cysts) when your health care provider may not even be concerned about such things.

And that's before accounting for some of the factors that the model doesn't consider: the disagreement in the polls, the unusual nature of Trump's candidacy and the demographic changes it is producing, Clinton's superior turnout operation, the possibility of «shy Trump» voters, the fact that the news cycle is still somewhat fluid headed into the final weekend, the declining response rates to polls, and the substantial number of high - profile polling misses around the world over the past few years.

· A Four - Year Term For The Legislature: Calling it a «a game changer,» Attorney General Schneiderman proposed a constitutional amendment to change the length of legislators» terms to four years, in order to end the two - year cycle of non-stop re-election fundraising and campaigning.

By contrast, Europeans pay a «VAT» - a value added tax - a more complicated scheme by which each time a product changes hands in the business development cycle, a portion of the added value is taxed and used for funding.

Shah said the $ 1.5 million budgeted for the digital program, which could change later in the cycle, is similar to what the group spent in 2014.

In the run up to last Thursday's London Mayoral election Sadiq Khan pledged to freeze fares on public transport for the next four years, increase spending on cycling and he has since promised to introduce a new one hour bus ticket allowing unlimited changes within an hour.

This training also seeks to support the FOISECON in order to build their capacity to conduct free and credible elections at the local government levels and how well - implemented electoral process can bring about peaceful change of power and improve their leadership skills and take on board means for preventing or mitigating the escalation of electoral violence and conflict throughout the respective electoral cycle.

Katko is running for reelection in a congressional district that has changed parties for the last five election cycles, and has expressed concern over Trump's tone and divisive rhetoric, saying Trump will have to earn his vote.

The elderly, disabled and terminally ill are today protected by the law, but in an age when the call upon the state budget to care for the elderly is high, and at a trying time in the economic cycle, how safe would people feel if that law were to change?

If I'm president for X number of years, and there's a wave of change in the next election cycle, my like - minded justices serve as an enduring bulwark against out of control foolishness of those who don't agree with my own irrefutable wisdom.

For a presidential cycle known for upending conventional political wisdom, one thing certainly hasn't changed: It's hard to vote in the Senate if you're campaigning across the countFor a presidential cycle known for upending conventional political wisdom, one thing certainly hasn't changed: It's hard to vote in the Senate if you're campaigning across the countfor upending conventional political wisdom, one thing certainly hasn't changed: It's hard to vote in the Senate if you're campaigning across the country.

Let's dedicate $ 100 million to transform every failing school in New York into a comprehensive, holistic, full - service community school and change the basic education system in this state and stop the cycle of incarceration in this state and paying for problems, rather than stopping the problems at an early age.

I have said before that I thought it was right for short - term commitments to be in line with the coalition spending plans, as changes inevitably produce disturbance to business cycles, but that doesn't prevent Labour from saying that long - term they would seek to ameliorate the concerns of public sector - workers, e.g. future pay increases would be above inflation to restore the earning power that was lost through the recession.

It is why we must seize this critical moment in our state's history to fundamentally and permanently change the redistricting process by amending our constitution to take the pen out of the legislators» hands and place it with an independent commission for future redistricting cycles.

The included remote control makes it really easy for you to change the temperature and cycle through the 3 different fans speeds no matter where you are in the room.

Even though the effect may in practice be less due to changing conditions, Blocken hopes that his findings will convince the UCI, the international cycling union, to change the rules for following team cars.

Over the course of the menstrual cycle, its composition changes, becoming thicker and rich with blood vessels in preparation for pregnancy, but if the woman does not conceive, the uterus sheds this tissue, causing the woman's period.