Sentences with phrase «for channel function»

Not exact matches

Searching for Morgan Freeman, for example, will turn up a list of the actor's movies that are on Netflix, Crackle and Popcornflix, the three channels included in the search function to start with.

Slack allows for organised and searchable channels of communication sorted by type — projects, pitches, finance, HR — so everyone who needs information on a particular business function can access it quickly and easily.

As President and CEO of TD Ameritrade, he is primarily responsible for the oversight of the strategy and operations supporting the company's three client channels: Retail Investing, Trading and Institutional, along with additional responsibilities overseeing technology, operations and corporate functions.

I think the last rate cut also showed that the efficacy of the move was more limited than the BoC let on, with most of the net stimulus (through the FX channel) ultimately a function of the projected path for U.S. monetary policy.

So for example, in my case and that of other persons whose minds dissociate when we engage in intense / deep spiritual practices like intense / deep prayer, meditation, fasting etc and we hear voices, hallucinate, see visions, experience thought insertions, automatic channelling just like a spirit medium as well as other psychic phenomena (clairvoyance etc), and the mind dissociation makes some persons mentally and emotionally unstable; our minds enter an altered state of consciousness just like those of the Buddhist monks but in our case the altered state of our brains results in psychotic and psychic symptoms being induced (interestingly, some persons who are ignorant of how the human brain functions chalk up these experiences to demonic attack)......... are these psychotic, psychic experiences which persons like myself experience a gift from God as well?

And of course it contains a communications function, placing an RNC brand and magic «donate» button right on your desktop as well as opening up a new channel for direct messages from the Republican overlords.

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

Therefore, Lambert - Eaton syndrome IgG reacts with voltage - dependent calcium channels and blocks their function, a phenomenon that can account for the presynaptic impairment characteristic of this disorder.

One such drug — known as a Kv3 potassium channel modulator, in development by U.K. - based Autifony Therapeutics — may help improve neuron function in the part of the brain responsible for processing sounds.

Several years ago, when Feske and his colleagues were at another institution, they were the first to identify ORAI1, a new calcium channel, which is essential for calcium influx and T - cell function.

Proteins are fundamental macromolecules for life, with a diversity of functions, like acting as channels through cellular walls, catalysers, DNA benders, etc..

Most of the BMBF's support for stem cell research is channelled through two priority programmes: «Biological Replacement of Organ Functions» and «Tissue Engineering».

For calcium channels, Yue's and other research groups found that the resemblance element supports an important function, preventing the channel from opening when the cellular calcium level gets high.

A cryo — electron microscopy structure provides a framework for understanding function and disease mechanisms in a family of calcium channels.

For years, scientists have been unsure how calcium ion channels function.

The structure of synaptophysin suggests that the protein may function as a channel in the synaptic vesicle membrane, with the carboxyl terminus serving as a binding site for cellular factors.

«We know dysregulation of a protein enzyme called multifunctional CaM kinase II plays a role in disrupting sodium channel function in cardiac disease, but it was a matter of determining how this occurred and whether we could we prevent it for therapeutic benefit,» said Hund, an associate professor of biomedical engineering at The Ohio State University.

For example, the identification of highly specific and potent CFTR inhibitors has led to a number of studies examining the role of CFTR ion channel function in basic physiological processes.

For example, UT Southwestern's program was one of the first to use anti-lymphocyte antibodies to prevent and treat rejection; calcium channel blockers to improve the early function of transplanted kidneys; and molecular biology to better match donor kidneys with the patients who need them.

The channel - like property could have evolved, says Edwards, to meet the important need of moving large amounts of glutamate quickly, for while the other neurotransmitters are involved in modulating behaviors, such as mood, and therefore don't need to act with millisecond speed, glutamate functions by rapid - fire communication between closely placed nerve cells, and could require the fast action of the channel mechanism.

Objective: To develop artificial «ionic machines» for active manipulation and control of ion and fluid transport through nanometric channels, thereby imitating the functions of ionic machinery found in nature.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranfunction and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranfunction relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranfunction of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranFunction in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranfunction and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranfunction and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranfunction of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranfunction relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranfunction of the ATP - binding cassette (ABC) transporters

To gain an understanding of how electrical synapses specifically form between neurons, we are interested in determining which gap junctions identified in the reconstruction of the nervous system have UNC - 7 as a component, which other innexins contribute to these junctions, what determines specificity for forming complete channels, and how these gap junctions function to direct information flow in the nervous system.

One group is dedicated to passing chemical messages and is crucial for the brain to function - we'll call them «good» channels.

These channels, which derive their name from the fact that stretching the cell membrane causes them to open, are responsible for regulating the mechanical functioning of cells — a cellular sense of touch.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasFor example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasfor example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

The Allocator is responsible for carrying out allocations and replenishment functions for total Retail DTC channel: Full - Price, Off - price and Ecommerce under the direction of the Merchandise Planner.

The Allocator is responsible for carrying out allocations and replenishment functions for total Retail DTC channel: Full - Price, Off - price and Ecommerce under the direction of the Merchandise...

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Radio: Audi MMI Navigation Plus w / MMI System - inc: Audi connect (subscription required) w / Google Earth navigation, 8 - inch central display screen, control knob and buttons in center console, Operates climate control, central locking, instrument cluster, vehicle diagnostics, cellular phone, navigation, CD and radio functions, Also includes 2 USB ports w / AMI functionality (no AMI cable), Bluetooth streaming audio, Bluetooth wireless technology preparation for mobile phone, HD Radio Technology, MMI touch and Jukebox, SD card slots w / 64 GB capacity (dual slots), SiriusXM Satellite Radio (subscription required), INRIX XD online traffic and voice control system (controls cellular phone, CD, radio and navigation), speech - to - text, Audi Sound System, 10 speakers including front center speaker and subwoofer in the rear, 180 watts and a 6 - channel amplifier

These heady power reserves are channeled through a standard seven - speed AMG Speedshift automatic gearbox offering three driving modes as well as a stop / start function for added fuel savings in urban driving conditions.

As well as the usual electric windows, heated seats and satellite navigation that you expect, for an extra # 3,895 the premium plus pack provides keyless entry and engine start, memories for the driver and passenger seats, a panoramic glass roof with sliding front section, headlamps with 84 individually controlled LEDs, «active lighting» with motorway function and adaptive high beam assist plus a Burmester sound system with 13 speakers and a nine channel amplifier with total output of 590 watts.

Steering - wheel controls are available for volume, audio channel, and the usual cruise - control functions; the nav option adds further controls to the wheel.

-- A solid body structure as stiff as any in the global midsize sedan market, allowing for precise tuning and dynamic vehicle control — A premium steering gear that ensures smooth, precise responsiveness and on - center feel — Proven and continuously refined MacPherson strut front and mutli - link rear suspensions — Large, ventilated front disc and solid rear disc brakes, clamped on by dual - piston front and single - piston rear aluminum calipers, which are expected to deliver best - in - class stopping distance — An isolated engine cradle for tuned, refined feedback, without noise or vibration — Fuel - saving electric power rack - and - pinion variable - effort power steering, resulting in effortless low - speed maneuvers and a higher degree of steering feel at higher speeds — Chassis control technologies include four - channel anti-lock brakes, full - function traction control, four - corner electronic stability control, electronic brake force distribution, brake assist system, corner brake control, hydraulic brake fade assist and drag torque control.

The Acura / ELS Surround ® audio system also features a Note function for XM ® Radio that allows the driver to later recall the song title, artist, a short excerpt of the actual song along with the XM ® channel that played the song.

IAP WINDOW CONVERSION KIT — Includes two pieces of tempered automotive safety glass, two upper window channels, four anti-rattle weather - strips, and installation instructions; Get Cal - look windows and retain function; One - piece window glass fits into stock window area; Eliminates factory vent window and division bar; Choose from clear or gray - tinted glass; Original doorstops must be removed for easy installation.

Dual view touch screen, Navigation and hybrid TV system, Park distance control, PAS, Personal telephone integration with Bluetooth and voice recognition, Service interval indicator, Trip computer with selectable speed limit warning, DAB Digital radio, iPod connection lead, Logic 7 Hi - fi (19 Speaker surround sound harmon kardon system), Portable audio system, Acoustic glass, Body coloured bumpers, Electric folding door mirrors, Electric tilt / slide sunroof, Electric windows with one touch open, Front bumper with titan painted splitter bar and fog lamp bezels, Front fog lights, Green tinted glass, Headlamp wash / wipe, Heated electric door mirrors, Heated windscreen, Illuminated tread plates with RR lettering, Rain sensor including auto headlights activation, Rear wiper, Asymmetric split fold rear seat, Autobiography luxury floor mat with leather edging, Driver's lumbar support, Driver's seat height adjustment, Electric adjustable front seats, Electric adjustable steering column, Front and rear head restraints, Front centre armrest, Gearshift paddles, Heated and cooled front seats, Heated rear seats, Isofix child seat preparation, Leather gear knob / gaiter, Leather handbrake grip, Leather headliner, Loadspace cover, Memory function for drivers seat & exterior mirrors, Multi function steering wheel, Oxford leather upholstery, Parking heating with remote, Puddle and footwell lamps, Rear centre armrest with 2 cupholders, Autobiography noble finish design pack - Range rover, 3 rear 3 point seatbelts, 4 channel ABS, CBC -(Cornering brake control), Driver and passenger airbags, Driver / front passenger head + thorax airbag, Drivers knee airbag,DSC - Dynamic Stability Control, DTC - Drag torque control, EBD + Brake Assist, Electronic parking brake, Electronic traction control, Front seatbelt pretensioners with force limiters, Front side airbags, Hill descent control, Roll stability control, Cat.

7» touch screen with 4x4 information, Ambient / Solar sensor with ext temp warning, Cruise control, Intelligent terrain recognition software, Message centre, Park distance control, PAS, Personal telephone integration with Bluetooth and voice recognition, Push button tailgate release, Rear view camera, Service interval indicator, Trip computer with selectable speed limit warning, Tv / navigation system with tmc, Venturecam, 6 CD autochanger, Logic 7 Hi - fi (14 Speaker surround sound harmon kardon system), Auto dimming interior mirror + powerfold door mirrors, Body coloured bumpers, Brunel power vents, Electric front + rear windows, Electric sunroof, Front fog lights, Green tinted glass, Headlamp wash / wipe, Heated electric door mirrors, High mounted stop lamp, Laminated front side glass, Rear wiper, Asymmetric split fold rear seat, Boot mounted additional accessory socket, Centre console storage, Climate control / driver / pass temp controls, Driver's lumbar support, Driver's seat height adjustment, Dual blade sunvisors, Electric adjustable front seats, Electric adjustable steering column, Front and rear head restraints, Front centre armrest, Front cupholder, Heated seats front and rear, Heated steering wheel, Illuminated driver / passenger vanity mirrors, Illuminated load area and glovebox, Isofix child seat preparation, Leather gear knob / gaiter, Leather handbrake grip, Left and Right interior flood lamps, Memory function for drivers seat, steering wheel & exterior mirrors, Multi function steering wheel,One - touch auto control of air distribution / demist, Parking heating with remote, Programmable interior lamp, Rear centre armrest with 2 cupholders, Removable load compartment cover, Waterfall front and rear interior illumination, 3 rear 3 point seatbelts, 4 channel ABS, Driver and passenger airbags,DSC - Dynamic Stability Control, EBD + Brake Assist, Electronic traction control, Front and rear head airbags, Front seatbelt pretensioners with force limiters, Front side airbags, Hill descent control, Side impact protection beams, Battery back up and emergency key access, Central locking, superlocking and lazy locking with combination ignition key and remote transmitter, Ultrasonic alarm with passive / robust immobiliser, Electronic air suspension / variable ride height, Full size spare wheel

BMW apps interface, BMW emergency call, BMW information plus, BMW Online services, BMW remote services, BMW teleservices, Brake pad wear indicator warning light, Check control system, Digital clock, Door / boot open warning light, Front / rear park distance control, Lights on warning, Oil temperature gauge, On board computer, On board diagnostics, Operation warning of all exterior lights, Outside temperature display, Professional multimedia navigation system, Push button starter, Real time traffic information, Run flat tyre indicator, Service interval indicator, Traffic message channel (TMC), Auxiliary point for auxiliary devices, BMW professional radio / CD / MP3, CD Changer preparation, DAB Digital radio, «Guide me home» headlamps, 2 speed adjustable intermittent wipers with wash / wipe function, Automatic dimming rear view mirror, Automatic headlight beam throw control, BBody colour roof mouldings, Body colour bumpers, Body colour door handles, Body colour electric adjustable door mirrors, Brake force display, Chrome exhaust tailpipe, Clear indicator lenses, Daytime running lights, Door sill finishers, Dynamic brake lights, Electric front and rear windows with one touch / convenient open / close function, Front fog lights, Front ornamental grille with chrome plated kidney bars and chrome bezel, Green tinted heat insulating glass, Heated rear window with automatic switch off, Heated windscreen washer jets, High gloss shadow line, Rain sensor + automatic driving lights control, Shark fin roof aerial, 12 V sockets in front centre console and passenger footwell, 2 x folding cupholders in instrument panel above glovebox, 3 rear seat head restraints, 4 foldable grab handles - rear with clothes hook, 4 lashing points to secure luggage, Automatic interior light soft on / soft off system, Driver and passenger sunvisors with vanity mirrors + slide cover, Dual zone automatic air conditioning, Folding front centre armrest + storage, Front and rear door armrests, Front and rear velour floor mats, Front door storage bins with bottle holder, Front sports seats with electric side bolster adjustment, Glovebox light, Height adjustable front headrests, Indirect front interior illumination - soft - light function, Individual anthracite headlining, Isofix system on outer rear seats, Leather gear knob, Leather gear selector lever handle, Leather handbrake grip, Lockable glovebox, Luggage compartment lighting, M sports leather steering wheel,Multi - function controls for steering wheel, Reach + rake adjustable steering column, Rear centre armrest, Rear storage compartm

BMW ConnectedDrive - Assist, BMW ConnectedDrive - Online, Colour information display, IDrive controller on centre console, Lane departure warning system, On board computer including check control information bar, Park distance control, Professional multimedia navigation system, Run flat indicator (RFI)- tyre puncture warning system, Service interval indicator, Servotronic Power Assisted Steering, Speed limit display, 6 disc DVD player, Auxiliary point for auxiliary devices, CD player, Body colour bumpers, Body colour roof rain channels, Electric folding and auto dimming door mirrors, Electric front and rear windows with fingertip open / close + anti-trap all round, Electric glass roof with sliding and vent function, Electrically heated door mirrors, Follow me home headlights, Front fog lights, Headlight wash system, Heated washer nozzles, High beam assistant, Illuminated door handles, Interior mirror with automatic anti dazzle, Rain sensor including auto headlights activation, Single quadrilateral tailpipe, Xenon headlights, Ambient interior lighting, Anthracite Velour floor mats, Automatic air conditioning / automatic air recirculation, Cup holders, Driver + front passenger electric lumbar support, Footwell lights at rear, Front footwell lights, Front head restraints, Front / rear centre armrests, Front / rear reading lights, Heated front seats, Isofix child seat attachment, Lidded glovebox,Multi - function controls for steering wheel, Rear headrests, Steering wheel with electric reach / rake adjust and memory, Advanced Head Protection System front + rear,Anti - lock Brake System + Electronic Brakeforce Distribution + Brake assist, Comfort exit stepless door brake, Crash Sensor - activates hazard / interior lighting + unlocks doors, Driver and passenger airbags, Dynamic stability control plus, Electromechanical parking brake + automatic hold function, Emergency boot release, Front passenger airbag deactivation, Front seatbelt force limiters, Fuel cut off safety device, Height adjustable front seatbelts, Occupancy sensor for passenger seat, Pyrotechnically pre-tensioned front seatbelts, Side airbags, Three 3 point rear seatbelts, Warning triangle and first aid kit, Central locking fuel filler cap, Immobiliser, Locking wheel bolts, Remote alarm system, Remote central locking, Safety battery terminal, Run flat tyres

BMW ConnectedDrive - Assist, BMW ConnectedDrive - Online, Colour information display, IDrive controller on centre console, On board computer including check control info bar, Park distance control, Professional multimedia navigation system, Run flat indicator (RFI)- tyre puncture warning system, Service interval indicator, Servotronic PAS, Body colour bumpers, Body colour roof rain channels, Electric folding and auto dimming door mirrors, Electric front and rear windows with fingertip open / close + anti-trap all round, Electrically heated door mirrors, Follow me home headlights, Front fog lights, Headlight wash system, Heated washer nozzles, High beam assistant, Illuminated door handles, Interior mirror with auto anti dazzle, Rain sensor including auto headlights activation, Xenon headlights, Ambient interior lighting, Anthracite Velour floor mats, Auto air con / auto air recirculation, Cup holders, Footwell lights at rear, Front footwell lights, Front head restraints, Front reading lights, Front / rear centre armrests, Heated front seats, Isofix child seat attachment, Lidded glovebox, Multi-function controls for steering wheel, Rear headrests, Steering wheel with electric reach / rake adjust and memory, ABS+EBD+B rake assist, Advanced Head Protection System front + rear, Comfort exit stepless door brake, Crash Sensor - activates hazard / interior lighting + unlocks doors, Driver and passenger airbags, DSC +, Electromechanical parking brake + auto hold function, Emergency boot release,

BMW ConnectedDrive - Assist, BMW ConnectedDrive - Online, Colour information display, IDrive controller on centre console, Lane departure warning system, On board computer including check control info bar, Park distance control, Professional multimedia navigation system, Run flat indicator (RFI)- tyre puncture warning system, Service interval indicator, Servotronic PAS, Speed limit display, Auxiliary point for auxiliary devices, CD player, Body colour bumpers, Body colour roof rain channels, Electric folding and auto dimming door mirrors, Electric front and rear windows with fingertip open / close + anti-trap all round, Electric glass roof with sliding and vent function, Electrically heated door mirrors, Follow me home headlights, Front fog lights, Headlight wash system, Heated washer nozzles, High beam assistant, High gloss shadow line, Illuminated door handles, Interior mirror with auto anti dazzle, M aerodynamic bodystyling, Rain sensor including auto headlights activation, Single quadrilateral tailpipe, Xenon headlights, Ambient interior lighting, Anthracite Velour floor mats, Auto air con / auto air recirculation, Cup holders, Driver + front passenger electric lumbar support, Footwell lights at rear, Front footwell lights, Front head restraints, Front / rear centre armrests, Front / rear reading lights, Isofix child seat attachment, Lidded glovebox, M leather steering wheel, Multi-function controls for steering wheel, Rear headrests, Steering wheel with electric reach / rake adjust and memory, ABS+EBD+B rake assist, Advanced Head Protection System front + rear, Comfort exit stepless door brake, Crash Sensor - activates hazard / interior lighting + unlocks doors, Driver and passenger airbags, DSC +, Electromechanical parking brake + auto hold function, Emergency boot release, Front passenger airbag deactivation, Front seatbelt force limiters, Fuel cut off safety device, Height adjustable front seatbelts, Occupancy sensor for passenger seat, Pyrotechnically pre-tensioned front seatbelts, Side airbags, Three 3 point rear seatbelts, Warning triangle and first aid kit, Central locking fuel filler cap, Immobiliser, Locking wheel bolts, Remote alarm system, Remote central locking, Diesel particulate filter, Dynamic Drive, Safety battery terminal, Run flat tyres

That format is not a requirement for the comic book... it was simply a function of the distribution channels available at the time.

The Sina Tech report says that, over the past few months, Amazon has shut down Chinese site Ikandou's download channels for Kindle eBooks, and clamped down on Douban's Kindle function.

Chinese media reports have said that, over the past few months, Amazon has shut down Chinese site Ikandou's download channels for Kindle eBooks, and clamped down on Douban's Kindle function.

Our affiliation with Principal provides deep resources for support functions, such as finance and legal, as well as access to distribution channels that provide growth opportunities for our firm.

For them to perform their diversified functions, those channels need to receive, at their outer lobule border, blood from the intestine that is rich in absorbed nutrients.

Whether it is through the oblique nature of our informational channels which function as echo chambers reminiscent of the earliest ways Nationalism spread through print media or the conflation of meaning with sacrifice, it is clear that there are precedents for how Nationalism as a construct has led to and sustained cycles of violence.

These four channels measure the atmospheric temperature in four thick layers spanning the surface through the stratosphere...... The brightness temperature for each channel corresponds to an average temperature of the atmosphere averaged over that channel's weighting function.

The three channels use the same frequency but different carbon dioxide cell pressure, the corresponding weighting functions peaks at 29 km for channel1, 37 km for channel2 and 45 km for channel3.