Sentences with phrase «for chondrocyte»

SOX9 and its co-factors SOX5 and SOX6 form a trio that is required for chondrocyte differentiation and thereby for cartilage formation and maintenance.

Rho - kinase inhibitor Y - 27632 (ROCKi) is a potential drug molecule, which has been reported to support the gene expressions typical for the chondrocytes, thus restricting their phenotypic conversion to fibroblastic cells upon the cellular expansion.

Not exact matches

This may entail making small holes in the bone to allow new cartilage to grow (microfracture), taking cartilage from another part of the athlete's knee and transplanting it into the defect (osteochondral autograft transfer), taking cartilage cells from the knee and then having them grown in a lab for later re-implantation (autologous chondrocyte implantation), or taking cartilage from a person who has passed away and placing it in the defect (osteochondral allograft transfer).

For instance, to make a rod with collagen fibers aligned along its length (like a tendon) they cultured chondrocyte cells in a dog bone - shaped mold with loops on either end.

One exciting potential for Permacol is that it can be seeded with the patient's own cells, so that in the future it may be possible to repair cartilage or bone by seeding with chondrocytes or osteocytes.

«Cartilage cells (or chondrocytes) isolated and expanded from cartilage tissue have great potential as a cell - based therapy for patients with, for example, traumatic cartilage defects,» says Juha Piltti, doctoral student at the Department of Integrative Medical Biology.

«Our paper is a blueprint of how the cartilage - producing cell, called a chondrocyte, is made and maintained by Sox9,» said He, a postdoctoral research associate in the lab of Andy McMahon, director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC.

The team discovered that a certain subset of cartilage - making cells, known as chondrocytes, replicate themselves, make other bone cells and drive bone growth — findings that could lead to new treatments for children with facial deformities who normally have to wait until adulthood for corrective surgery.

Molecules known to affect FGFR3 signaling and / or the metabolism of chondrocytes, the cells responsible for growing cartilage, were identified as good candidates.

The findings suggest that reductions in the number of cartilage - producing cells, and greater risk for osteoarthritis, may be driven not just by lower adenosine levels but also by lower levels of the protein on the surface of chondrocytes designed to receive and pass on adenosine's signal.

Cronstein and his team also found that levels of adenosine A2A receptors went up on rat chondrocytes when osteoarthritis was present, in what the researchers say was a «failed attempt» to compensate for the loss of adenosine from the energy - processing (metabolic) changes underlying the inflammation.

The means to enhance the production of cartilage - specific extracellular matrix is needed for cell - based tissue engineering applications, since cultured chondrocytes quickly lose their cartilage - specific phenotype.

Perivascular cells, including pericytes in the smallest blood vessels (e.g., microvessels) and ARCs around larger ones, express mesenchymal stem cell markers and bear a multi-differentiation fate potential (differentiate into osteoblasts, chondrocytes, adipocytes, smooth muscle cells and myocytes) similar to that documented for MSCs in vitro.

Stage - specific embryonic antigen - 4 is not a marker for chondrogenic and osteogenic potential in cultured chondrocytes and mesenchymal progenitor cells.

Based on previous protocols [5, 6] they have now created a 3D protocol for chondrogenic lineage differentiation via the generation of a putative chondrogenic progenitor cell population, and have found that using this protocol C - iPSCs can be readily differentiated into cartilage in a manner comparable to that of mature chondrocytes [7].

The choice of the somatic cell for reprogramming, the reprogramming technology chosen, and the differentiation techniques utilised, all work synergistically towards the production of mature iPSCs - derived chondrocytes which are comparable to patient - derived chondrocytes, in line with Good Manufacturing Practice guidelines for an «off - the - shelf» stem cell product.

However, autologous chondrocytes lack long term proliferation and functionality in vitro, and so another cell source is being searched for which could produce chondrocytes with an increase in functional lifetime.

Even the authors of the esteemed Small Animal Surgery textbook assert, «Most NSAIDs interfere with chondrocyte (cartilage cells) glycosaminoglycan synthesis and therefore should be used continuously only for a short time.»

These substances are well known for promoting the increased production of chondrocytes or the cells that make up the cartilage found in the ends of adjoining bones.

for article Activation of α2A - adrenergic signal transduction in chondrocytes promotes degenerative remodelling of temporomandibular joint.