Proteins necessary
for ciliogenesis are manufactured in the endoplasmic reticulum before traveling to the trans - Golgi network to be sorted into «zip - coded packages» or vesicles for transport to the cilia.
Much must go right
for ciliogenesis to occur.
We want to understand how different RFX transcription factors are required
for ciliogenesis control and how they are involved in ciliary specialization in mouse tissues.
Caenorhabditis elegans ciliary protein NPHP - 8, the homologue of human RPGRIP1L, is required
for ciliogenesis and chemosensation.
Not exact matches
Drosophila Chibby is required
for basal body formation and
ciliogenesis but not
for wingless signaling.
Among them, there are genetic instability (mainly aneuploidy, a defect in chromosome number), defects in the symmetry of cell division (important
for cell fate specification and tissue architecture) and impaired
ciliogenesis.
Further elucidating the pathways that underlie impaired
ciliogenesis is an essential step in beginning to develop treatment options
for PKD and other ciliopathies.»
In the JBC article, Lipschutz and his MUSC coauthors go a step further — showing in cell culture and a zebrafish model that depletion of Tuba, a guanine nucleotide exchange factor required
for Cdc42 activation, also disrupts renal
ciliogenesis.