Sentences with phrase «for cytotoxic»
We developed a series of novel proteasome inhibitors selective for each of the three protease sites and demonstrated the relative importance of inhibiting each site for cytotoxic activity (Shabaneh et al, PlosOne 2013).
http://cancer.dartmouth.edu/
Thus, STxB is a highly specific transport vehicle for cytotoxic agents in gastric carcinoma.
Given the aggressive nature of BPDCN and the need for cytotoxic chemotherapy the patient elected to terminate her pregnancy which was a difficult emotional decision for her and her spouse to make.
Not exact matches
No targeted therapy has been approved for noninflammatory and inflammatory triple - negative breast cancer tumors, and the standard of therapy for these tumors is a combination of conventional cytotoxic chemotherapeutic agents.
Histone deacetylase (HDAC) inhibitors have shown promise in «flushing out» HIV from latently infected cells, potentially exposing the reservoirs available for elimination by cytotoxic T lymphocytes (CTL), also called killer T cells.
Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.
«PD - L1 allows immunosuppressive lymphocytes to suppress cytotoxic T cells, but it's also their «Achilles heel,»» said Karin, who is also the Ben and Wanda Hildyard Chair for Mitochondrial and Metabolic Diseases.
The CNIC research team generated cytotoxic memory T cells specifically targeting cancer by using different methods for vaccination with tumor antigens.
Besides expanding the ranks of cytotoxic T cells, IL - 33 seems to prime them for combat.
Some of these T cells become «effectos» (the ones that have direct roles in the immune response, including helper functions for CD4 + T cells, and cytotoxic functions for CD8 + T cells), while other T cells differentiate into resting memory cells.
Studies in CD8 knockout (KO) and perforin KO mice demonstrated that CD8 + cytotoxic T lymphocytes (CTL) are unnecessary for the rejection of corneal allografts in mice (8, 9).
New research from La Jolla Institute for Allergy and Immunology lays the groundwork to parse how the virus interacts with its host and causes disease by pinpointing CD8 + T cells, a subset of T cells more commonly known as cytotoxic or killer T cells, as important gatekeepers that control Zika infection or limit the severity of disease.
Therefore, to overcome chemoresistance mediated by EMT, drug screening efforts have focused on eliminating the mesenchymal subpopulation by searching for drugs with preferential cytotoxic effects on mesenchymal, rather than epithelial HMLE subpopulations [7].
The laboratory of Vincenzo Cerundolo is the first group to report the use of tetrameric soluble class I / peptide complexes (tetramers) for the identification of tumor - specific cytotoxic T lymphocytes (CTLs), and subsequently shows that these novel reagents allow rapid and accurate analysis of human CTL responses.
The actin cytoskeleton and cytotoxic T lymphocytes: evidence for multiple roles that could affect granule exocytosis - dependent target cell killing.
Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control.
Chemotherapy for MDS patients involves the use of medicines that kill cells cancer cells called cytotoxic agents.
The targeted drug delivery appears to be a very promising strategy for controlling the biodistribution of the cytotoxic agent only on malignant tissues by linking it to tumor - targeting moiety.
«The observed increase in the ratio of cytotoxic CD4 T cells to CD4 helper T cells indicates that they are an important component of the protective immune response to viral infections and that their induction should be an important marker for successful vaccinations against certain viral diseases,» says postdoctoral researcher and first author Veena Patil, Ph.D. «But we really didn't know enough about their molecular profile and the mechanisms that drive their differentiation and maintenance.»
A Non-randomized, Open - label Dose - finding Trial of Combined Cytotoxic and Immune - Stimulatory Strategy for the Treatment of Resectable Primary Malignant Glioma
This study illustrates the potential benefits of using GHRH antagonists for the treatment of cancers that are highly resistant to cytotoxic agents such as doxorubicin.
We also investigate the mechanisms that in dendritic cells allow for early endosomal escape of antigens leading to subsequent crosspresentation to CD8 + cytotoxic T lymphocytes.
Importantly, this automated screening assay allowed us to interrogate some of the specific molecular mechanisms that may be responsible for the targeted cytotoxic effect amiodarone HCL had on NSCs and not cells differentiated from NSCs.
Borrego F, Robertson MJ, Ritz J, Pena J, Solana R. CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor.
Lymphocytes (T - cells = Thymic lymphocytes = killer T cells (aka CD8 +, cytotoxic T cells) & Helper T cells (aka CD4 +)-RRB- patrol the body constantly looking for suspicious invaders or unnecessary elements through the release of lymphokines.
Worked in a Phase I / II clinical trials research laboratory that focuses on the development of antigen - specific cytotoxic T - lymphocytes for adoptive cellular immune therapies in children and adults
Richards, R.L., Rao, M., Wassef, N.M., Glenn, G. M., Rothwell, S. W., Alving, C.R. Liposomes containing lipid A serve as an adjuvant for induction of antibody and cytotoxic T - cell responses against RTS, S malaria antigen.