Not exact matches
Drawing on Toronto's leading stem cell and
tissue engineering expertise, one group will focus on new models
for repairing
damaged hearts.
On average the transplanted stem cells regenerated 40 percent of the
damaged heart tissue, said Dr. Michael Laflamme, UW assistant professor of pathology, whose team was principally responsible
for generating the replacement
heart muscle cells.
Now, with new kinds of technologies that are coming up, new types of
tissue engineering and, you know, some of the hopes that people have
for stem cells and [the] like, it may be interesting to see if there are other ways, alternatives to dealing with really badly
damaged hearts that would involve growing a new
heart or replacing or repairing the
damage d to a badly
damaged heart that might make artificial
hearts less important in the somewhat more distant future.
«It is our hope that Dr. Yin's research will lead to additional potential therapeutic agents like ZF143 to reactivate mechanisms
for the repair and regeneration of
damaged heart muscle
tissue in humans.»
Exploiting that power, researchers are now using microRNAs to convert the scar
tissue of
damaged hearts into healthy muscle cells, opening the door
for a better therapy after
heart attacks and
heart failure.
Some experimental
heart attack treatments require surgery to open up the chest, but the two hydrogel materials already in clinical trials are injected into the
damaged tissue through a long catheter inserted through the skin — eliminating the need
for open - chest surgery.
The result — the second such finding in the past year — suggests that similar cells from human testicles might have similar powers, paving the way to creating replacement
tissue for men who have suffered
damage from
heart attacks or other injuries and avoiding some of the controversy surrounding embryonic stem cells (ESC).
Currently, patients receive no medication before undergoing routine angioplasty, the standard treatment
for removing a
heart blockage that causes a
heart attack and
damages heart tissue.
For many years, scientists worldwide have been searching for ways to stimulate the regeneration of damaged heart tiss
For many years, scientists worldwide have been searching
for ways to stimulate the regeneration of damaged heart tiss
for ways to stimulate the regeneration of
damaged heart tissue.
But the process, which is often set in motion by cells of the immune system, can also occur whenever
tissue is
damaged — even in the absence of a pathogenic organism — as,
for example, when you stub your toe or, more seriously, suffer a
heart attack.
Srivastava, director of the Gladstone Institute of Cardiovascular Disease, was selected
for his innovative cardiology research on the regeneration of
damaged heart tissue.
Because humans have a limited capacity
for heart tissue regeneration,
damaged heart muscle is normally replaced with a nonfunctional scar.
Scientists at the Bar Harbor - based MDI Biological Laboratory have been awarded a patent — the first
for the lab —
for MSI - 1436, a potential new
heart disease drug that stimulates the repair and regeneration of
heart tissue damaged by injuries and
heart attacks.
Friedreich's ataxiais an inherited disease that causes progressive
damage to the nervous system, resulting in symptoms ranging from gait disturbance to speech problems; it can also lead to
heart disease and diabetes.The ataxia of Friedreich's ataxia results from the degeneration of nerve
tissue in the spinal cord, in particular sensory neurons essential (through connections with the cerebellum)
for directing muscle movement of the arms and legs.
5/15/2008 New Role Found
for a Cardiac Progenitor Population In a discovery that could one day lead to an understanding of how to regenerate
damaged heart tissue, researchers at the University of California, San Diego have found that parent cells involved in embryonic development of the epicardium — the cell l...
The U.S. Patent and Trademark Office has announced that it will grant a patent to MDI Biological Laboratory scientists Voot P. Yin, Ph.D., and Kevin Strange, Ph.D., and their collaborator Michael Zasloff, M.D., Ph.D.,
for use of the small molecule MSI - 1436 to stimulate the repair and regeneration of
heart tissue damaged by injuries such as a
heart attack.
But
heart cells never truly regenerate in the
damaged tissue, and myofibroblasts compensate
for their absence by forming a stiff, collagenous scar that interferes with the
heart's ability to maintain stable
heart rhythms and to expand and contract forcefully to pump blood.
When a person has a
heart attack,
for instance, scar
tissue forms in the
damaged area and it can no longer function like it's supposed to.
The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated
for a sufficient period of time, can cause
damage or death (infarction) of
heart muscle
tissue (myocardium).
Adults over 65 are at increased risk
for complications from pneumonia, and serious cases that require hospitalization have been linked to long - term health issues like cardiovascular
tissue damage and an increased risk of
heart disease.
[1] The parasite is commonly called «heartworm»; however, adults often reside in the pulmonary arterial system (lung arteries), as well as the
heart, and a major effect on the health
for the animal is a manifestation of
damage to the lung vessels and
tissues.
If the heartbeat remains high
for a long period of time, your dog could suffer from
heart tissue damage and
heart failure due to liquid build - up in the lungs.
ACT - activated clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test
for proteins specific to a disease causing organism or virus Alb - albumin (liver, kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood antibody test
for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase enzyme — non specific (pancreatitis) ANA - antinuclear antibody (systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT - activated partial thromboplastin time (blood clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band cell — type of white blood cell Baso basophil — type of white blood cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible
for jaundice from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (kidney and liver function) Bx biopsy C & S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho] kinase (muscle disease,
heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced by the adrenal glands (adrenal gland function) Coomb's anti- red blood cell antibody test (immune - mediated hemolytic anemia) Crea creatinine (kidney function) CRT - capillary refill time (blood pressure,
tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical
heart activity,
heart arryhthmia) Eos eosinophil — type of white blood cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound by protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup of white blood cells Hb, Hgb hemoglobin — iron rich protein bound to red blood cells that carries oxygen (anemia, red cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed - cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type of white blood cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed - cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&S that determines antimicrobial selection Mono monocyte — type of white blood cell MRI magnetic resonance imaging (advanced
tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood cell — immature red blood cell (bone marrow
damage, lead toxicity) PCV, HCT, MHCT packed - cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet — cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type of white blood cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test
for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppression)