Sentences with phrase «for disease modelling»

These two properties (self - renewal and pluripotency) confers human pluripotent stem cells a unique interest for clinical applications since they could allow the production of infinite quantities of cells for disease modelling, drug screening and cell based therapy.

Indeed, these cells could in turn be used for disease modelling and drug discovery.

This accomplishment opens the door for disease modeling and drug screening and brings personalized cell therapy a step closer for patients with diabetes.

Working with the Institute for Disease Modeling in Bellevue, Washington, the researchers tried to predict how much impact a weekly drug could have on preventing HIV infections.

These in turn can be used for disease modeling and drug discovery, but hopefully one day also for cell - based therapy of the many devastating diseases such as Alzheimer and Parkinson's Disease.

«Creating iPSCs from patient cells carrying genetic mutations is not only useful for disease modeling, but can also offer new insights into the reprogramming process.»

the generation of novel mouse models of Cystic Fibrosis by exploring genetically - diverse murine populations that will provide unique tools for disease modeling and pre-clinical studies.

INFRAFRONTIER open call for disease model development and systemic phenotyping published.

However, despite its marked promise for disease modeling, development of novel therapies, and regenerative medicine, stem cell derived organoid technology faces many remaining challenges.

This makes a strong case for the utility of lineage through program cells for diseased modeling.

«During the next 10 years,» says Svendsen, «we're going to see a trend away from using animals for disease modeling and using human cells with iPS technology instead.»

We therefore suggest that the presence of the mutated transgenes (AβPP and PS1), which are per se the basis for the genetic form of Alzheimer's disease in humans, directly interferes with gut function as shown here for the disease model mice.

The efficient genome editing shown here demonstrates that these pigs can serve as a powerful tool for dissecting in vivo gene functions and biological processes in a temporal manner and for streamlining the production of genome - edited pigs for disease modeling.

Not exact matches

But aside from raising awareness and more than $ 20 million for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, over the past month, the challenge also may be unleashing a new model for the $ 300 billion - a-year business of charitable giving.

The role that big pharma plays in research, while valuable, is often tenuous, because profit models for many diseases are not always apparent, at least in the short term.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

Kogan wrote in the email that he wanted to create statistical models that could accurately identify people at risk for various diseases and illnesses by examining their Web browsing and purchase behaviors, and combine that with medical data from Harvard.

As we begin to access God's power to defeat the Sin - disease and discover and use our own legitimate power to live, we step into the spiritual world, where God shares the keys to life and reality (A Hunger for Healing: The Twelve Steps As a Classic Model for Christian Spiritual Growth [NY: HarperCollins, 1991], pp. 4 - 6).

[111] Cf. Jim D. Broadfoot, Richard C. Rosatte, and David T. O'Leary, «Raccoon and Skunk Population Models for Urban Disease Control Planning in Ontario, Canada,» Ecological Applications 11, no. 1 (2001).

Maine statute directed the committee to develop this model policy based on the current research and best practice guidelines from the national Centers for Disease Control and Prevention and other states» concussion management documents.

Several of these programs have received national and international recognition, including designation as model programs by the American Psychological Association, the American Medical Association, and the Centers for Disease Control and Prevention.

Although the observational studies that underlie our models all adjusted for multiple confounders, including known risk factors for the disease outcomes of interest, risk factors for early breastfeeding cessation such as preterm birth, preeclampsia, and obesity are also risk factors for metabolic disease in later life.

To account for potential overlap among hypertension, diabetes, and MI, we modeled transitions over time between comorbid disease states using a first - order Markov process.

When logistic models were stratified by the presence or absence of hypertensive disease, only maternal age older than 34 years (odds ratio [OR], 1.4; 95 % confidence interval [CI], 1.0 - 2.0), pregnancy - associated plasma protein - A of the 95th percentile or less (OR, 1.9; 95 % CI, 1.2 - 3.1), and alpha fetoprotein of the 95th percentile or greater (OR, 2.3; 95 % CI, 1.4 - 3.8) remained statistically significantly associated for abruption.In this large, population - based cohort study, abnormal maternal aneuploidy serum analyte levels were associated with placental abruption, regardless of the presence of hypertensive disease.

Creating and maintaining a healthy lifestyle that you stick to beyond the birth will also make you a model of healthy living for your child, helping him / her to avoid obesity, diabetes, heart disease and other conditions for a lifetime.

The Dr Hadwen Trust for Humane Research claims that «in some instances, reliance on inaccurate animal «models» of human disease have undoubtedly delayed medical progress.»

The response in Newburgh was crafted in consultation with the U.S. Centers for Disease Control and Prevention and will serve as a national model for understanding PFOS exposure, state Department of Health spokesman James Plastiras said.

«And we're going to be working with our federal colleagues at the Agency for Toxic Substances and Disease Registry to understand the best way to do this and create a national model for how to respond to these effectively,» Graber says.

«I'm interested in bridging gaps between traditional epidemiology and mathematical modeling, hopefully developing improved methods for studying infectious diseases,» she says.

Medicines that are personally tailored to your DNA are becoming a reality, thanks to the work of U.S. and Chinese scientists who developed statistical models to predict which drug is best for a specific individual with a specific disease.

Benjamin «Benjy» Firester, 18, of New York City, won the top award of $ 250,000 for developing a mathematical model that uses disease data to predict how weather patterns could spread spores of late blight fungus, which caused the Irish Potato Famine.

Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

Human tissue grown in the laboratory offers a critical model for understanding the disease process.

In an e-mail to Nature a few days later, Kogan said that zebrafish might be a useful model organism for psychiatric disease after all.

For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

Scientists for the first time have assembled a «disease in a dish» model that pinpoints how a defect in the blood - brain barrier can produce an incurable psychomotor disorder, Allan - Herndon - Dudley syndrome.

«I had been thinking about model organisms for a very long time in academia, and when I started to realize that there were all these people clamoring for their rare diseases I thought, «Why aren't people using model organisms to study them?

Researchers at the Centers for Disease Control and Prevention built computer models, which predicted that, if a massive intervention failed to materialize, by January 2015 up to 1.4 million people could be infected.

«What we had done for the cystic fibrosis pigs was applicable to other diseases» for which the previous animal models were not sufficient, Rogers says.

The key problem for research on smallpox is that there is no good animal model for the disease.

Exposed to both air and fluid, the cells might also be used to model the lungs and test drugs for lung disease.

«Gene - delivery system prevents vision loss from inherited eye disease: Initial testing in animal models holds promise for treating Leber congenital amauroisis and other congenital visual disorders.»

«Using that approach, can we screen for guide RNAs that have unusually strong protective activities in a model of neurodegenerative disease.»

«Now we have two interesting models that are selectively targeting specific parts of the brain: the thalamus in FFI and the hippocampus in CJD,» says Jackson, who is now a Group Leader at the German Center for Neurodegenerative Disease.

«This study is important, in part because we now have a new xenograft model that will for the first time allow us to apply new biomarkers to better predict disease progression and test new therapeutics.»

As for the Lund researchers, the method provides a tool for studying how neurons cooperate inside a healthy brain and in animal models with different neurological diseases.

«The next step for us is to generate a true disease model,» he says.