Sentences with phrase «for drug discovery efforts»

Attrition of novel drug candidates due to cardiovascular liabilities (including proarrhythmic risk due to delayed ventricular repolarization and Torsades - de-Pointes arrhythmia) remains a hurdle for drug discovery efforts, a hurdle which may be mitigated by the use of human induced pluripotent stem - cell derived (hiPSC)- cardiomyocytes.

Not exact matches

Academic efforts in drug discovery also exist at other institutions, such as Baylor University's Center for Drug Discovery, Harvard University's Laboratory for Drug Discovery in Neurodegeneration, and many othdrug discovery also exist at other institutions, such as Baylor University's Center for Drug Discovery, Harvard University's Laboratory for Drug Discovery in Neurodegeneration, and many othDrug Discovery, Harvard University's Laboratory for Drug Discovery in Neurodegeneration, and many othDrug Discovery in Neurodegeneration, and many others.

Their discovery of the LDL receptor and their efforts to understand how the protein functioned are credited with laying the foundation for the development of the blockbuster class of cholesterol - lowering statin drugs.

Companies in the partnership supply compound libraries and drug discovery expertise to the effort, while academic partners contribute knowledge about the disease and facilities for screens and assays.

Chemogenomics is a new concept where drug design and screening is conducted at the genome level for selective drug discovery effort against one target among a large family of related proteins / receptors.

Toxicology, the traditional tests for adverse drug effects, continues to drive early drug discovery efforts.

«Techniques like this one that enable controlled, remote C - H activation are just beginning to be adopted by industry, and should provide a boost to drug discovery and development efforts for many years to come,» Yu said.

The convergence of several factors explains the trend: cheaper genetic sequencing technologies, the discovery of new oncogenes (genes that can cause a normal cell to become cancerous), a new generation of computers and bioinformatics that can analyze vast amounts of data, and a multibillion - dollar effort by researchers inside and outside the pharma industry to develop targeted drugs and companion diagnostics for cancer.

A $ 1.7 million drug discovery effort to identify molecular and genetic risk factors and new therapeutic targets for cognitive decline and Alzheimer's disease, based on data from the Religious Order Study and the Rush Memory and Aging Project.

This mechanism includes potential targets for next - generation drug discovery efforts to treat metabolic diseases including diabetes and obesity.

This mechanism includes potential targets for next - generation drug discovery efforts to treat met... more

The consolidation of these efforts in an independent initiative will allow faculty from the CMI to lead a focused investigation in small molecule drug discovery for multiple therapeutic applications.

New York, NY — January 31, 2006 — The Spinal Muscular Atrophy Foundation announced the completion of a new licensing agreement that will facilitate access to intellectual property fundamental to drug discovery efforts for the disease.

Such information will be valuable for the discovery of the genetic causes of human diseases and will aid efforts to identify new drug targets.

ANN ARBOR, Mich. — Sept. 15, 2008 — Assay Designs and the Spinal Muscular Atrophy Foundation (SMAF) are very pleased to announce a collaborative agreement for development of reagents and assays for SMN (Survival Motor Neuron) protein to expedite drug discovery and development efforts for spinal muscular atrophy (SMA), the leading genetic cause of mortality in infants and toddlers.

This effort, which will enhance deCODE's proprietary gene and drug target discovery work and may provide genetic markers for additional diagnostic development, will leverage Illumina's Sentrix ® HumanHap BeadChips; Infinium ™ assay and LIMS (laboratory information management system); as well as analysis and visualization tools from Illumina's BeadStudio software.

«This funding will help provide important new opportunities to translate basic discoveries and leading - edge technologies from UC San Diego's research laboratories into needed therapies for patients — an effort being spearheaded by our new Drug Discovery Institute,» said Palmer Taylor, PhD, associate vice chancellor for Health Sciences and dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences.

Another reason why EPA started with estrogen was that high - throughput in vitro assays were already developed either commercially for use in drug discovery by the pharmaceutical industry or through an interagency government effort called Toxicology Testing in the 21st Century, or Tox21.

Despite ongoing efforts toward finding novel entities for the treatment of the most challenging cancers, translation into patient benefit has been slow due to the fact that translational cancer research from early drug discovery to late stage drug development and assessment in clinical trials is a long process.

On July 30, 1999, the Company sold its drug discovery assets and ceased its internal drug discovery operations and research efforts for collaborative partners.