Sentences with phrase «for drug resistance»

Such a priori knowledge would greatly empower serial monitoring strategies for drug resistance in the clinic as well as the development of trials for drug - resistant patients.

«Screening for drug resistance is key to improving treatment approaches for many cancers,» said Shana Kelley, scientist and professor at the Leslie Dan Faculty of Pharmacy, University of Toronto.

Comparisons of these emergent species and other pathogenic fungi will enable evolutionary studies, revealing, for instance, fungal genes that are conserved or under selection and which could be important for drug resistance and virulence.

Using new genome sequencing technologies, the researchers discovered multiple strains of the malaria - causing parasite Plasmodium falciparum that appear to be rapidly expanding throughout the local parasite population in Western Cambodia, a known hotspot for drug resistance.

Members of the Conserved DedA Family Are Likely Membrane Transporters and Are Required for Drug Resistance in Escherichia coli.

That information could alert the clinician to the potential for drug resistance.

However, testing for drug resistance is not cheap or simple, so it's not routinely done, Oren says.

«Given that it's happening, we should at least understand what the consequences might be for drug resistance,» he said.

The regrowth of cancer stem cells is responsible for the drug resistance that develops in many breast tumors and the reason that for many patients, the benefits of chemo are short - lived.

She has tracked dramatic increases in the prevalence of several genes and suites of genes coding for drug resistance.

«This is a mechanism for drug resistance.»

But the rapid rise of bacterial genes for drug resistance stems from more than lucky mutation, Levy adds.

Not exact matches

I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.

Pathogens — bacteria, viruses, and fungi — can develop resistance to the drugs used to treat them when people take them incorrectly or stop taking them too soon, for instance.

Resistance is also fueled by the massive and often inappropriate use of antibiotics in agriculture; for decades these precious drugs have been used to promote growth and fend off costly infections that can result from the cramped conditions of industrial - scale food animal production.

In modern Rio, they are the alternative to the drug - traffic, the main resistance movement in terms of the forging of identity, values and respect for the force of the community.

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Treating malaria with chloroquine is no longer a viable option for most people as the parasite has developed resistance to the drug.

The memorandum of understanding identified four areas in the life sciences where AAAS and the Cuban Academy of Sciences will seek opportunities for sustained cooperation: emerging infectious diseases, brain disorders, cancer, and antimicrobial drug resistance.

As a result, Soviet pharmaceutical companies churned out billions of units of questionable drugs that were only partially effective at normal dosages, weakening bacteria but not killing them outright — an environment perfect for spurring antibiotic resistance.

The bacteria behind gonorrhoea readily acquire genes for resisting drugs and so from 2012, UK patients were given two antibiotics at once — azithromycin pills plus a ceftriaxone injection — so if bacteria acquired resistance to one, they would be killed by the other.

«There's a huge, unmet clinical need for new approaches against staph skin infections because of declining antibiotic development and rising drug resistance,» says Lloyd Miller, M.D., Ph.D., associate professor of dermatology at the Johns Hopkins University School of Medicine.

If patients develop resistance to these drugs, there are even fewer choices left to treat the infection, which lasts for life.

The drug - like compounds can be modified and developed into medicines that target a protein in the human body that is responsible for chemotherapy resistance in cancers, said biochemist Pia D. Vogel, lead author on the scientific paper reporting the discovery.

As a result, P - gp causes resistance of the diseased cells to a majority of drugs currently available for the treatment of cancer, as well as drugs used for treatment of infectious diseases like HIV / AIDS.

For example, bacteria would typically develop drug resistance by evolving a mutation that breaks down the drug.

So far there's no approved drug on the market that reverses cancer chemotherapy resistance caused by P - glycoprotein, or P - gp for short, said Vogel, a biochemistry professor at SMU.

For the past decade, Gerry Wright has been trying to understand the rise of drug resistance by combing through the world's richest natural source of resistance - enabling DNA: a clod of dirt.

Scientists have made a major breakthrough in the global search for a new drug to beat the malaria parasite's growing resistance to first - defence treatments.

Mitchell Cohen, a microbiologist at the Centers for Disease Control and Prevention, in Atlanta, says that although he finds the EGS approach to drug resistance «very clever,» in the long run, it may be no more effective than another new antibiotic.

The ability for cancer cells to develop resistance to chemotherapy drugs — known as multi-drug resistance — remains a leading cause for tumor recurrence and cancer metastasis, but recent findings offer hope that oncologists could one day direct cancer cells to «turn off» their resistance capabilities.

«For years, researchers have focused on delivering more chemotherapy drugs into cancer cells using nanoparticles, without targeting the root of drug resistance,» He said.

While researchers have long worked with nanoparticles for drug delivery, the findings put forth by He and his team represent a crucial breakthrough in addressing multidrug resistance in cancer cells.

«As part of the strategy to combat the antibiotic resistance crisis, we should think about strategies to use less drugs and use drugs for shorter duration.»

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

GTC recognized the need to demonstrate on its own the potential for the technology and, in the late 1990s, began a clinical trial of human antithrombin for patients undergoing bypass surgery who develop resistance to the anticoagulant drug heparin.

Detection technique may pave the way for a more tailored treatment that delays the onset of drug resistance

The authors also call for fundamental changes in public health and drug treatment messaging: «Public education about antibiotics should highlight the fact that antibiotic resistance is primarily the result of antibiotic overuse and is not prevented by completing a course,» they wrote.

In a new Essay publishing 28 December in the open access journal PLOS Biology, Kristofer Wollein Waldetoft and Sam P. Brown of Georgia Institute of Technology propose that development of alternative therapies for mild infections could help slow the development and spread of antibiotic resistance, thereby preserving the drugs» effectiveness for use in severe infections.

Hence, both of the drugs could serve as alternatives for treating CML — especially in patients who have developed a resistance to the medication they have been receiving so far.

Globalization, changing climate, and the threat of drug resistance have conspired to set the stage for that perfect microbial storm: a situation in which an emerging pathogen — another HIV or smallpox, perhaps — might burst on the scene and kill millions before we can respond.

If these peptides are developed for therapeutic use, the researchers anticipate that they could be used either in stand - alone therapy or together with traditional antibiotics, which would make it more difficult for bacteria to evolve drug resistance.

Combining drugs from multiple classes into so - called cocktails makes it harder for the rapidly mutating virus to evolve resistance, but adding a single drug to a failing cocktail quickly breeds resistance to it, too.

«Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research found many targeted therapies for prostate cancer may not be effective against tumors in African - American men.»

Despite the availability of many excellent antibiotics, bacteria are developing resistance to those most commonly used, forcing physicians to give higher doses or fall back to «last line of defense» drugs, said co-senior author Dr. Erdal Toprak, Assistant Professor of Pharmacology and in the Cecil H. and Ida Green Comprehensive Center for Molecular, Computational, and Systems Biology and a Southwestern Medical Foundation Scholar in Biomedical Research at UT Southwestern.

So, Lee is optimistic about the potential for resistance to drugs like LJ001.

Dr David Aanensen, head of the Centre for Genomic Pathogen Surveillance and joint lead author on the paper said: «Drug resistance is a growing problem both in Europe and across the world and doctors need fast and accurate information to stop epidemics.

IN AN attempt to slow antibiotic resistance, the US Food and Drug Administration (FDA) is phasing out the use of antibiotics for fattening up livestock.

In the paper, the scientists show that combining the drug - resistance profile of a bacteria with its whole - genome DNA sequence allowed them to build up a series of drug - resistance «DNA photofits» for resistance to specific drugs.

Both groups confirmed in genetic, cell, and clinical studies that, for the first time, the parasite had developed resistance to both drugs used in an ACT.