Sentences with phrase «for drugs designed»

By uncovering the precise cellular mechanisms of nicotine's effect, this study suggests new and more precise targets for drugs designed to block this powerful craving.

This finding suggests new targets for drugs designed to treat inflammatory diseases.

Prior to that he was CEO of Molecular Simulations, Inc., a $ 100 MM supplier of software for drug design now called Accelrys (NASDAQ: ACCL).

Shokat says the presence of this cysteine conveyed certain chemical properties that gave his team a unique handle for drug design.

The structure reveals key interactions that probably contribute to the high catalytic efficiency of this enzyme relative to other flaviviruses, indicating promising starting points for drug design.

Li summarized, «Features of K - Ras - membrane interactions may steer us in a different and novel direction for drug design.

K - Ras has long been a top target for drug design.

«Identifying new pathways that can be targeted for drug design is an important step forward in improving the treatment of depressive disorders,» said Sarah Brooker, the first author and an M.D. / Ph.D student at Northwestern University Feinberg School of Medicine.

The finding suggests that vitamin C added to existing TB drugs could shorten TB therapy, and it highlights a new area for drug design.

«The chemical diversity found in nature has always been a significant source of inspiration for drug design and development, but although the medicinal properties of plants have been recognized for thousands of years, marine environments remain relatively unexplored,» said Jane Ishmael, Ph.D., associate professor of pharmacology at Oregon State University and the lead author of the new study.

This unusual binding mechanism opens a new avenue for drug design: Scientists can consider less rigid protein targets and identify molecules that stabilize more mobile forms of the protein upon binding — somewhat like a ski boot with an adaptable inner liner that continually adjusts to the foot.

This is all - important for drug design.»

«It could have implications for drug design and it certainly presents a new target.

Others, noting that structural data may be valuable for drug design, argued frankly that too - rapid data release would impede patenting.

«How they accomplish this is not well understood, but it is of great significance for drug design.»

«These new findings will have important implications for drug design by clearly defining exactly how these signals become integrated, so we will be able to predict how changes in a drug's design could affect signaling.»

Phenylalanine pairs capable of forming a molecular switch are also present in many other signaling proteins, including receptors in human cells, making it an attractive target for drug design and biotechnology applications.

«These peptides should be valuable for drug design and discovery, and for understanding fundamental aspects of cellular biology,» said John Sondek, PhD, senior author of the JBC paper and professor in UNC's departments of pharmacology and biochemistry & biophysics.

«These peptides should be valuable for drug design and discovery, and for understanding fundamental aspects of cellular biology.»

The work elements of a Biophysicist refers to researching and developing studies on human genetics, requesting grants from institutions that offer research funds, performing experiments with various scientific equipments, investigating the molecular basis of diseases and how proteins work for drug design.

Not exact matches

In particular, the complaint alleges that throughout the Class Period, defendants made materially false and / or misleading statements and / or failed to disclose that (1) the trials for GED - 0301 suffered from fatal design defects, such that GED - 0301 had failed to demonstrate meaningful clinical efficacy; (2) the growth of Otezla sales had dramatically slowed during Celgene's third fiscal quarter of 2017; and (3) the clinical and nonclinical pharmacology data in Celgene's new drug application («NDA») for Ozanimod were insufficient to permit a complete review by the FDA, which resulted in the FDA issuing a refusal to file letter to Celgene regarding the NDA.

• Rani Therapeutics, a San Jose, Calif. - based developer of a pill designed to replace injectable drug delivery for patients suffering from chronic diseases, raised $ 53 million in funding.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

One founder told CNBC that he uses Provigil, a drug designed for narcolepsy, to stay alert.

Other sources provide services to keep costs low: Science Exchange connects scientists with experts; and Transcriptic is a cloud - based biotech lab testing experimental drugs, while Gingo Bioworks designs custom microbes for customers.

Langer, an MIT Institute Professor with some 750 patents issued or pending worldwide, was one of the first people to apply chemical engineering methods to medical applications, pioneering the use of specially designed polymers for targeted drug delivery and tissue regeneration.

Why it matters: Understanding molecules in exact detail will allow chemists to design more effective drugs and better materials for generating and distributing energy.

Dr. Chawla designed and led the ATHOS 3 Phase 3 trial for La Jolla Pharmaceutical's FDA - approved drug for shock, Giapreza ™.

But those plans are specifically designed for small businesses and would probably be able to skirt a requirement in the Affordable Care Act that requires health plans sold directly to consumers to offer a basic set of benefits, such as prescription drugs and maternity care.

Erin's primary responsibilities at RA Capital are to manage the design and creation of all internal and external documents and resources for the company, including competitive landscapes of drugs and medical devices for disease indications and capabilities, set brand standards, and oversee internal and external marketing efforts.

Pass - through pricing, low admin fee, complete transparency, granular benefit design, intelligent clinical rule configuration for optimal drug utilization, unlimited formulary tier design and superior member experience through mobile cloud are a few of the many services delivered through this agreement.

We need to design clinical trials and outcomes in a way that captures the downsides of aging in a quantitative way» that allows targets for drug approvals by the FDA.

I and others of like mind criticized the drug culture and related antics as a self - indulgent distraction from the goals of racial justice and peace, and worried that the new enthusiasm for «ecological consciousness» was in fact a conservative ploy designed to turn the movement away from the cause of the poor.

The evolutionary principles of natural selection, variation, and recombination are the basis for genetic algorithms, an engineering technique that has many practical applications, including aerospace engineering, architecture, astrophysics, data mining, drug discovery and design, electrical engineering, finance, geophysics, materials engineering, military strategy, pattern recognition, robotics, scheduling, and systems engineering.

Write, telegraph, phone, and make personal calls on legislators and governmental officials (national, state, and local) encouraging them to support legislation designed to provide humane treatment for alcoholics, drug addicts, the mentally ill, and the mentally retarded.

Every since mankind has been as the Apostle described us in his epistle (Again, 2 nd Timothy 3:1 - 5; see also what Jesus said in Mark 7:20 - 23), the only thing that has «advanced «at our hands is our architecture, our technology, and our search for medicinal cures for what ails us.No one is denying that we've done tremendous good with these various advances, but we've also done awful, vicious, horrendous atrocities and brutalities as well.I've heard it quoted that out of all the centuries, millennia that we've considered ourselves «civilized», we've had only a few hundred years where something approximating peace has held sway among us.So again, I'm all world seeking to «make the world a better place», as it were; I just believe that mankind in his present moral, ethical, and spiritual configuration is capable of doing so.We can always enhance out technological prowess, improve our architechural designs, and make our drugs more powerful, but what about our hearts?

Modern Packaging designs and manufactures precision packaging systems for the food, dairy, cosmetic and drug industries.

Honored for Enhanced User Experience, this advanced packaging solution supports a number of features designed to monitor the quality of medicines shipped to patients and improve medication adherence of patients to prescribed drug therapies.

DRUGS AND ALCOHOL: just say no is a beautifully illustrated handout designed specifically for fathers, to help them communicate effectively with their children on the topics of drugs and alcDRUGS AND ALCOHOL: just say no is a beautifully illustrated handout designed specifically for fathers, to help them communicate effectively with their children on the topics of drugs and alcdrugs and alcohol.

She has received more than 40 grants from the National Institute of Mental Health and the National Institute on Drug Abuse to design prevention programs for children and families at high risk for HIV, mental health problems, suicide, and substance abuse.

Little Remedies offers a variety of drug - free products designed for baby's nose like Little Remedies ® Sterile Saline Nasal Mist and Little Remedies ® Saline Spray / Drops.

I tried everything, and eventually settled on taking the maximum dose of Domperidone, a drug that was actually designed for stomach issues, but doubles as a galactagogue.

Meanwhile, Cuomo ended his three - day State of the State tour Wednesday with a speech in Albany that featured a renewed call for ethics reform and a proposal designed to cap the sky - high prices of prescription drugs in New York.

The county lawmakers expressed particular concern that Erie County is spending $ 301,000 a year to staff a 24 - hour addiction hotline, designed to connect addicts with treatment and be a one - call resource for drug treatment referrals and advice.

«We could apply the strategy used in this study to quickly identify and design small molecule drugs for other RNA - associated diseases,» explained study first author Sai Velagapudi, a research associate in the Disney lab.

«If we know how these sensations are transmitted, we can design specific drugs or therapies to block the neurotransmitters, block the receptors for the neurotransmitters or reduce the degree to which those neurotransmitters work,» Mishra says.

Randolph Nesse and Kent Berridge, psychiatric investigators with the Institute for Social Research at the University of Michigan in Ann Arbor, reported in Science that medicine may never win the war against drug addiction because «it is rooted in the fundamental design of the human nervous system.»

«This discovery opens the way for the rational design of a new generation of antipsychotic drugs, hopefully with more desirable effects and fewer side effects.»

One of those licenses went to Michael Hackett, a UNC doctoral student who got an idea 2 years ago for a potential commercial drug: to trick tumors into absorbing chemotherapy drugs by designing a molecular Trojan horse.

Two other multi-national trials randomized 27,438 patients to either bococizumab or placebo and were designed to evaluate the impact of the drug on cardiovascular outcomes, including nonfatal heart attack and stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death.