Sentences with phrase «for duration risk»

This environment emphasizes that investors need to make suitable and precise choices for duration risk.

We are getting decent compensation for duration risks, so I would buy some amount of long Treasuries.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Potenza: As the yield curve flattens, investors get less compensation for moving further out on the curve and taking on more duration risk.

To manage risk, we set targets for duration, sector and credit quality factors which align with our interest rate outlook, industry sector and credit views.

In this case, I think what muni investors seek is a manager who knows how to conduct deep credit research, adjust for duration and monitor the market for risks and opportunities.

Interest rate risk Although high yield bonds have relatively low levels of interest rate risk for a given duration or maturity compared to other bond types, this risk can nevertheless be a factor.

Duration Risk: If interest rates do ever decide to rise, duration will be the most important statistic for bond investors to pay attenDuration Risk: If interest rates do ever decide to rise, duration will be the most important statistic for bond investors to pay attenduration will be the most important statistic for bond investors to pay attention to.

If you are a prodigious saver, are willing to keep your money safe for a set duration of time while earning an interest rate above the current risk free rate 10 Year Treasury, and are concurrently investing in other more aggressive instruments, I recommend diversifying your capital into a 5 - year CD account or longer duration.

«While shortening the duration of a TIPS exposure results in a lower yield, the chart below shows it still provides an attractive breakeven ratio, or yield received for the amount of risk that an investor takes.

While shortening duration can help mitigate interest rate risk, another approach to consider is one that balances exposure to the very front end of the curve with exposure to intermediate maturities for additional yield potential and lower volatility, given that rates are likely to rise slowly and stay historically low for the foreseeable future.

But if the average duration for these two funds is similar, then surely they both risk capital losses from higher interest rates?

As yields have fallen, duration, or rate sensitivity, has risen, meaning that the risk associated with a change in rates has generally risen for most bond benchmarks and traditional funds.

The risk - reward landscape for long - duration Treasuries is shifting, as this week's chart helps explain.

Unlike its duration - neutral sister fund HYZD, HYND is suitable for investors who seek to profit from an upward - interest - rate path or to use the fund as a tool to shorten their fixed - income portfolio duration, all the while maintaining credit risk exposure.

Last week saw the same U.S. - Canada trade, with equally weighted futures blocks also with a September expiration, though for about half the duration risk as Wednesday's transaction.

Fidelity ® Short Duration High Income Fund (FSAHX) This fund might be appropriate for investors looking for higher yield who are willing to take on more credit risk while limiting interest rate risk.

You want to trade him when demand is at its highest (in other words, when competitive teams panic) but you also need to move him before the foot issue returns, unless you're willing to risk keeping him for the duration of his contract.

If we honest about it for much of 2017 he was Sh ** We need more CM partnership options in a season duration — reliance upon ramsey to have the impact he showed 3 or 4 seasons ago is a risk.

Longer duration of breastfeeding may or may not affect the appearance of your breasts, but it will reduce the risk for breast cancer over your lifetime, in addition to the many other health benefits to you and to your breastfed baby.

Taking the present - day levels of contaminants in Norwegian breastmilk and the long duration of breastfeeding (12 months) in Norway into account, the Norwegian Scientific Committee for Food Safety concludes that contaminants poses a low risk to Norwegian infants, and that the benefits of breastmilk to Norwegian infants clearly outweigh the risk presented by contaminants.

If marketed to the age of 36 months, they risk being bottle fed for this duration and seriously damaging oral development, normal growth and other negative health impacts.

A longer duration of breastfeeding — for example more than 12 months (and this can be over several babies) is more protective, even if you are breastfeeding at all and whether you are mixed feeding with some breast milk and some formula, your breast cancer risks are reduced.

Most studies have revealed protective effects of breastfeeding on common infections in the first 8 to12 months of life.8, 27,29,30 One study, which distinguished between infectious diseases until and from the age of 6 months, revealed results similar to those from our study.24 Although the authors used exclusive breastfeeding for 3 months as the reference group, exclusive breastfeeding for 6 months reduced the risk of gastrointestinal tract infections between the ages of 3 and 6 months but not between the ages of 6 and 12 months.24 We can not explain why breastfeeding duration was only associated with lower risks of lower respiratory tract infection from 7 to 12 months.

Indeed, a long duration of breastfeeding (> 7 months) has been associated with a reduced risk of overweight and obesity, 2 while a short duration (≤ 4 months) may not be sufficient to obtain the beneficial effects of breastfeeding.3 Another confounding factor is early exposure to antibiotics, which is increasing even for minor infections.

However, the organization also called for more research regarding the benefits of 6 vs 4 months of exclusive breastfeeding.25 Thus far, several studies in industrialized countries revealed that a shorter duration of breastfeeding increases the risk of common infectious diseases, such as respiratory and gastrointestinal tract infections.8, 19,24,26, — , 32 However, in these studies, various definitions of the exclusiveness of breastfeeding were used24, 27,28,30 or the combination of duration and exclusiveness of breastfeeding was not taken into account.8, 31

Ollie improves the quality and duration of sleep for babies (including preemies and high risk), helps baby self - calm, and reduces colic.

Women who breastfeed for a shorter duration or not at all are at higher risk of many diseases, and they experience shorter birth intervals with resulting negative health outcomes.

It is important to note that duration of breastfeeding, the longer a mother breastfeeds in her life (one or more babies and the collective number of months), significantly impacts her risk for breast cancer; the protective effect of lactation on breast cancer risk is cumulative.

In a new study of over 7,000 older Chinese women published online today in the journal Rheumatology, breastfeeding — especially for a longer duration — is shown to be associated with a lower risk of rheumatoid arthritis (RA).

This analysis including 7 studies20,23,25,37 - 39, 42 showed that any breastfeeding for more than 6 months compared with a shorter duration was associated with a 17 % decreased risk for childhood leukemia (OR, 0.83; 95 % CI, 0.72 - 0.96).

Research has found that women's breast cancer risk declines in inverse proportion to the duration of breastfeeding: That is, the longer you breastfeed your baby, the lower your risk for developing breast cancer.

Paragraph 2: Change to read: The shorter the duration of breastfeeding the greater the risk of respiratory and gastrointestinal infections and the greater the risk of hospitalization for lower respiratory disease.

If parents are told not to bed - share and this affects the duration and exclusivity of breastfeeding, the risk of SIDS increases due to the need for artificial feeding.

Although pacifier use ultimately may be determined to be only a marker of women at risk for shortened breastfeeding duration, education and support of these women and their efforts to breastfeed is vital.

Some of the many benefits a Postpartum Doula provides for you and your baby include: Better infant care skills Positive newborn characteristics Breastfeeding skills improve A healthy set of coping skills and strategies Relief from postpartum depression More restful sleep duration and quality Education and support services for a smooth transition home A more content baby Improved infant growth translates into increased confidence A content baby with an easier temperament Education for you to gain greater self - confidence Referrals to competent, appropriate professionals and support groups when necessary The benefits of skin to skin contact Breastfeeding success Lessen the severity and duration of postpartum depression Improved birth outcomes Decrease risk of abuse Families with disabilities can also benefit greatly by learning special skills specific to their situation Families experiencing loss often find relief through our Doula services Improved bonding between parent and child.

Bar - Yam and Darby found that fathers influenced the breastfeeding decision, assistance at first feeding, duration of breastfeeding, and risk factors for bottle feeding [31].

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

Moreover, although this reduced the power of the multivariate analysis, the increased risk of low MDI and total IQ scores associated with a shorter duration of breast feeding persisted after adjustment for each of the confounders, including the Raven score.

The risk jumps sevenfold for a first - time mother and tenfold in pregnancies over 41 weeks in duration.

A significantly reduced risk of breast cancer was also found for those whose lifetime duration of lactation totaled 73 - 108 months (odds ratio = 0.47, 95 % CI: 0.23, 0.95) and for those who breastfed for > or = 109 months (odds ratio = 0.24, 95 % CI: 0.11, 0.53).

In adjusted analysis a shorter duration of predominant breast feeding (less than two months) was a risk factor for four or more hospital, doctor, or clinic visits because of upper respiratory tract infections (OR 1.43, 95 % 1.02 to 2.01, p = 0.041), as was partial breast feeding for less than six months (OR 1.46, 95 % CI 1.07 to 2.00, p = 0.018).

However, when duration of breastfeeding was examined, children who had breastfed for longer than six months had a 43 % reduction in risk for AML and a 28 % reduction in risk for ALL [13].

You're also missing prepayment risk (not a big deal but worth mentioning) as well as duration conversion (you are exchanging financial instruments with duration X for financial instruments with duration Y).

The two organisations warn that the highly effective two year Medical Training Initiative (MTI) that trains about 200 doctors a year from the developing world will be put at risk if the Government adopts its proposal to cut the duration of Tier 5 visas for temporary workers to just one year.

One of NASA's goals is to minimize the health risks associated with extended spaceflight, so it is critical that methods for preventing and treating spaceflight - induced illnesses be developed before astronauts embark upon long - duration space missions.

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes) shows that age (or age at diagnosis) and duration of diabetes disease are linked to the risk of death and marcovascular complications (those in larger blood vessels), whereas only diabetes duration is linked to the risk of microvascular complications (in smaller blood vessels such as those in the eyes).

This shows that even among those already considered to be at risk for cardiometabolic disease, in this case obese teens» decreased sleep duration was predictive of increased cardiometabolic risk.

For each 5 year increase in duration of diabetes, the risks of macrovascular events and all - cause death were increased by 13 % and 15 %, respectively, when accounting for age, or increased by 49 % and 78 %, respectively, when accounting for age at diagnosFor each 5 year increase in duration of diabetes, the risks of macrovascular events and all - cause death were increased by 13 % and 15 %, respectively, when accounting for age, or increased by 49 % and 78 %, respectively, when accounting for age at diagnosfor age, or increased by 49 % and 78 %, respectively, when accounting for age at diagnosfor age at diagnosis.

«But it's important to note that the duration of fever did not affect the risk of complications to the newborn, but only to the mother — leading to a caesarean delivery or vacuum extraction, for example.