Tachibana, M.; Sugimoto, K.; Nozaki, M.; Ueda, J.; Ohta, T.; Ohki, M.; Fukuda, M.; Takeda, N.; Niida, H.; Kato, H.; Shinkai, Y. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential
for early embryogenesis.
Not exact matches
«Our focus here has been on
early heart development, but the basic principles of patterning of human pluripotent stem cells, and subsequently differentiating them, can be readily expanded into a broad range of tissues
for understanding
embryogenesis and tissue morphogenesis,» said Healy.
Shp2,
for example, plays an essential role in
early embryogenesis and is also known to play a role in cancer.
«Our focus here has been on
early heart development, but the basic principles of patterning of human pluripotent stem cells, and subsequently differentiating them, can be readily expanded into a broad range of tissues
for understanding
embryogenesis and tissue morphogenesis,» said Dr. Healy.
We propose that a defect in the CNV formation process is responsible
for the «CNV - mutator state,» and this state is dampened after
early embryogenesis.
«Most of the epigenome is set during
embryogenesis and
early development,» says Jean - Pierre Issa, director of the Fels Institute
for Cancer Research and Molecular Biology at Temple University in Philadelphia.