Sentences with phrase «for effect modification»

All models were tested for effect modification by diet group.

Not exact matches

Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward - looking statements include, among others, the following: our ability to successfully and profitably market our products and services; the acceptance of our products and services by patients and healthcare providers; our ability to meet demand for our products and services; the willingness of health insurance companies and other payers to cover Cologuard and adequately reimburse us for our performance of the Cologuard test; the amount and nature of competition from other cancer screening and diagnostic products and services; the effects of the adoption, modification or repeal of any healthcare reform law, rule, order, interpretation or policy; the effects of changes in pricing, coverage and reimbursement for our products and services, including without limitation as a result of the Protecting Access to Medicare Act of 2014; recommendations, guidelines and quality metrics issued by various organizations such as the U.S. Preventive Services Task Force, the American Cancer Society, and the National Committee for Quality Assurance regarding cancer screening or our products and services; our ability to successfully develop new products and services; our success establishing and maintaining collaborative, licensing and supplier arrangements; our ability to maintain regulatory approvals and comply with applicable regulations; and the other risks and uncertainties described in the Risk Factors and in Management's Discussion and Analysis of Financial Condition and Results of Operations sections of our most recently filed Annual Report on Form 10 - K and our subsequently filed Quarterly Reports on Form 10 - Q.

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

Conversely, there are potential negative effects of testing modifications that should be carefully considered before choosing to use them for your child.

Among the modifications advocated by the SNA are: removing the new requirement that students take a fruit or vegetable with their meal; changes to the whole grain requirements; and extending the comment period for the interim final competitive food (school snack) regulations that are to go into effect this summer.

Two later studies not included in these meta - analyses reported equivalent or even larger protective associations.265, 266 The mechanism for this apparent strong protective effect is still unclear, but lowered arousal thresholds, favorable modification of autonomic control during sleep, and maintaining airway patency during sleep have been proposed.247, 267, — , 270 It is common for the pacifier to fall from the mouth soon after the infant falls asleep; even so, the protective effect persists throughout that sleep period.247, 271 Two studies have shown that pacifier use is most protective when used for all sleep periods.169, 266 However, these studies also showed increased risk of SIDS when the pacifier was usually used but not used the last time the infant was placed for sleep; the significance of these findings is yet unclear.

For business groups, the talk of making modifications and exceptions to the wage hike only proves their concern the increase could have a detrimental effect on jobs.

Greenwich Village Society for Historic Preservation executive director Andrew Berman said the new modifications make only a small dent in the negative effects of the plan, which calls for more than 2 million square feet of new construction.

Potential effect measure modification was evaluated and models adjusted for confounding effects of age, gender, race / ethnicity, diabetes, income and education.

To make up for those shortcomings, the report called for a research program, including smaller scale field trials, whose goal «should be to improve understanding of the range of climate and other environmental effects of albedo modification, as well as understanding of unintended impacts.»

What's more, say the researchers, the cancer - causing effects of off - target deletions mistakenly created by the V (D) J enzyme need to be considered in designing site - specific enzymes for genome modification such as zinc - finger nucleases, TALENS, or CRISPRs.

These researchers wanted to observe the effects of citrus flavanones for the first time on mice with no genetic modifications and that were fed a high - fat diet.

«While genetic modification of crops can introduce new beneficial traits into existing crops, the resulting products need to be tested for long - term health effects before making assumptions about their impact on human health,» said senior investigator Frances Sladek, a professor of cell biology and neuroscience at UC Riverside.

This demonstrates how a fairly subtle modification of a regulatory network, effected by a selector gene, can set off a chain of events that has powerful ramifications for morphogen signaling and organ size.

The result of this two - step gene modification — forcing expression of the receptor for NY - ESO - 1, and adding a blocker gene to nullify the effect of TGF - beta — is a super T cell engineered to both more effectively kill target cancer cells and to resist the tumor's attack.»

If you want to study the effects of one particular modification for which a targeted editor, like H3K27ac, is available, an epigenetic tool would be your best bet.

Although the authors caution that their results are approximations intended to guide future modeling efforts, this study provides fundamental information regarding the relative difficulty of achieving desired albedo modification effects and is an important starting point for understanding the limits of what is widely considered one of the most viable solar geoengineering techniques.

The reason for these differential effects of hypoxia may be due to the complex regulation of HIF - 1α activities by various subunits, posttranslational modifications, and the presence and effects of coregulators, which are known to vary between different cell types (6).

Moreover, as pointed out by Johnston et al. [17], the increasing importance of Ag - NPs in the development of novel consumer materials intended for human exposure requires more in depth studies on toxicity mechanisms, as well as, on how silver particles interact with biological molecules and how different surface modifications can be used to reduce or eliminate possible toxic effects.

• Focus on design and delivery skills for safe & effective hands - on assisting and adjusting • Sequencing flows for varying effects and fitness levels • Demonstrating & multitasking • Incorporating hands - on assists & modifications • Precision and clarity in languaging and effective cuing • Designing for mixed level classes • Leading vs. Teaching • How to teach new postures to beginners • Finding personal style • Assessing individual needs • Adapting and Responding • Experiential language

First, because of the wide array of genetic modifications available, we wished to test for these effects in mice.

Dietary fibre modifications that are low in fat and glucose reduce the risk for AD by not only effecting cell membranes and nutrient sensing G coupled receptors but also by regulating number of nuclear receptors such as histone deacetylases (HDAC) and peroxisome proliferator activated receptors (PPAR) that control glucose, fatty acids and cholesterol and have significant effects on the brain cholesterol homeostasis and amyloidosis.

The mechanism for this is not established but evidence supports direct action of KBs together with modifications in levels of hormones, which influence appetite, such as ghrelin and leptin.21 Here we can summarize (listed in order of importance and available evidence) that the weight - loss effect of VLCKD seems to be caused by several factors:

To minimize the confounding effect and test for potential modification by an overall lifestyle pattern, we further performed a stratified analysis according to a priori — defined healthy lifestyle pattern, as characterized by never smoking or ever smoking for fewer than 5 pack - years, never or moderate alcohol intake (< 14 g / d in women and < 28 g / d in men), body mass index (calculated as weight in kilograms divided by height in meters squared) of at least 18.5 and less than 25.0, and physical activity of at least 150 min / wk at a moderate level or at least 75 min / wk at a vigorous level (equivalent to ≥ 7.5 metabolic equivalent h / wk) as recommended.18 Likewise, given the previous report that protein intake was associated with a higher risk for diabetes - related mortality, 8 we examined the protein - mortality association according to the history of diabetes.

For the association between total and animal protein intake and type 2 diabetes, effect modification by sex (P < 0.001) and by BMI among women (P < 0.001) was present.

To learn more about Blue Screen techniques try the following sites: How a blue screen works: http://entertainment.howstuffworks.com/blue-screen2.htm A modification of the blue screen effect is responsible for making lightsabers look so exciting in Star Wars: http://entertainment.howstuffworks.com/question171.htm Build a blue screen at home: http://www.jushhome.com/Bluescreen/Bluescreen.html

RIM does not recommend running BESs with this Registry modification for long because it makes them much more susceptible to the effects of latency, but it should buy you a couple of months to rectify the source of the problem, which is the latency.

(A) The competitive impact of such judgment, including termination of alleged violations, provisions for enforcement and modification, duration of relief sought, anticipated effects of alternative remedies actually considered, whether its terms are ambiguous, and any other competitive considerations bearing upon the adequacy of such judgment that the court deems necessary to a determination of whether the consent judgment is in the public interest; and

ThirdEye allows users to apply several filters and effects in real - time, including emojis, sketch, text, and shapes, bring up the native photo editor for additional modifications, and share the results.

One commenter noted that the procedural modifications to the process for determining whether a borrower has an adverse credit history have been in effect for three years.

The veterinary behaviourist must also receive training in normal species typical behaviour, comparative animal behaviour, the principles of learning and behaviour modification, abnormal behaviour, psychopharmacology and the effects of disease on behaviour, and must work for at least two years seeing cases under the mentorship of a board certified behaviourist.

While some pheromone and nutraceutical products marketed for their calming effects can be helpful adjuncts to the treatment of mild anxiety and fear, «moderate to severe anxiety and fear - related conditions are more effectively treated with pharmaceutical drugs in combination with management and behavior modification,» Ballantyne said.

So basically it's your choice: you can ask your vet for a stronger drug that sedates your dog more but may cause side effects, or you can work on the whole behavior modification process that takes longer but works on the underlying problem.

However, keep in mind that United will ding you for more miles if you make any modifications to your plans after the new award charts go into effect on Feb 1.

«Many of the carcinogens present in mainstream smoke are known to exert their effects through a genotoxic mode of action, which is based on their ability to induce DNA damage and mutations, although an epigenetic mode of action, e.g., through aberrant DNA methylation and histone modifications, is also beginning to emerge for a few of these carcinogenic compounds.»

The observed effects of cryosphere reduction include modification of river regimes due to enhanced glacial melt, snowmelt advance and enhanced winter base flow; formation of thermokarst terrain and disappearance of surface lakes in thawing permafrost; decrease in potential travel days of vehicles over frozen roads in the Arctic; enhanced potential for glacier hazards and slope instability due to mechanical weakening driven by ice and permafrost melting; regional ocean freshening; sea - level rise due to glacier and ice sheet shrinkage; biotic colonisation and faunal changes in deglaciated terrain; changes in freshwater and marine ecosystems affected by lake - ice and sea - ice reduction; changes in livelihoods; reduced tourism activities related to skiing, ice climbing and scenic activities in cryospheric areas affected by degradation; and increased ease of ship transportation in the Arctic.

If the public is fully informed of the magnitude of the existing consensus in the scientific community, if the public is informed of how our modification of the atmosphere is effecting the climate, if the public learn of the magnitude of the effect those changes will have on the common wealth of the entire world, which I expect he would admit is necessarily going to be quite negative, and if the public are then presented with the choice of voting for a government which would take substantial meaningful action, does he suppose that the reaction would then be to do nothing?

(3) Where an employer on behalf of whose employees a trade union or council of trade unions, as the case may be, has been certified as bargaining agent or has given or is entitled to give notice under section 16 or 59, sells his, her or its business, the trade union, or council of trade unions continues, until the Board otherwise declares, to be the bargaining agent for the employees of the person to whom the business was sold in the like bargaining unit in that business, and the trade union or council of trade unions is entitled to give to the person to whom the business was sold a written notice of its desire to bargain with a view to making a collective agreement or the renewal, with or without modifications, of the agreement then in operation and such notice has the same effect as a notice under section 16 or 59, as the case requires.

Rule 8.5 reads in pertinent part as follows: A petition for modification of child support shall set forth the amount of child support currently in effect or shall set forth... the order sought to be modified or shall comply with Pima County Local Rule 8.2 (c).

The intent of a clause like this is to prohibit an oral modification of the contract, for example, by a salesman, from having legal effect.

The exemption takes effect in one year, to give regulatory authorities a chance to decide if they need to limit modification for other reasons than protecting copyright.)

For such modifications to have effect, they must be drafted very clearly and must not be in violation of current employment standards legislation.

What adverse effects will result from seeking modifications to the existing culture for economic reasons?

Indeed, a longitudinal Swedish study reports that «high achievers» used television as a complement to school learning, whereas «low achievers» used television as a substitute for it.16 Similarly, a study of 326 young children found that parental education is negatively related to hours watched overall.13 Other studies have found effect modification of the effects of television viewing on educational outcomes by the SES of the parents.14, 21 As a result, television viewing in a general population may serve to exacerbate disparities in cognitive outcomes between high - SES and low - SES households.

We formally tested for mediation of the relation between IPV and obesity by maternal depression using a bootstrap method.49 Owing to theoretical and empirical data suggesting differing associations between family and neighborhood violence exposure and BMI by sex, additional stratified analyses were conducted and effect modification was tested using interaction terms.

For example, more attention is being paid to the need for pilot and consultation work in the development phase of RCTs, 23 the importance of a more theory based approach to evaluation, 24 and the modification of intervention effects by context in community intervention trials.25 Statistical methods to integrate process and outcome data, such as those developed in the RIPPLE study, are a move forwaFor example, more attention is being paid to the need for pilot and consultation work in the development phase of RCTs, 23 the importance of a more theory based approach to evaluation, 24 and the modification of intervention effects by context in community intervention trials.25 Statistical methods to integrate process and outcome data, such as those developed in the RIPPLE study, are a move forwafor pilot and consultation work in the development phase of RCTs, 23 the importance of a more theory based approach to evaluation, 24 and the modification of intervention effects by context in community intervention trials.25 Statistical methods to integrate process and outcome data, such as those developed in the RIPPLE study, are a move forward.

Results After adjusting for confounding, there was some evidence of effect measure modification on the additive and multiplicative scales of childcare quality by income.

The highest age - specific rates in women for gonorrhea (GC) and chlamydia (CT) are seen in female adolescents aged 15 to 19 years, with disproportionately high rates in African Americans.1, 2 Understanding the effect of family context on STD acquisition in adolescent African American females is important because modification of family factors may influence STD acquisition.