Not exact matches
A critical discovery in this research was finding that the novel
progenitor has a receptor protein on its
cell surface called KDR, or vascular
endothelial growth factor receptor 2, which until now, was thought to be restricted to
endothelial cells that form vessels, the
progenitors for endothelial cells and the
progenitors blood
cells.
Researchers from Massachusetts Eye and Ear have,
for the first time, identified rapidly proliferating
cells (known as «neural crest - derived
progenitor cells») in the corneal endothelium of specimens from normal corneas and from corneas with Fuchs»
Endothelial Corneal Dystrophy (FECD), a condition in which the
cells responsible
for keeping the cornea clear die prematurely — often leading to blindness.
These
cells were then grown in the laboratory under special conditions to select
for stem - like
cells called
endothelial progenitor cells.
Researchers from the laboratories of Hiroshi Y. Yoshikawa and Hideki Taniguchi had previously demonstrated the in vitro formation of a 3D transplantable liver «organ bud» from human induced pluripotent stem
cells (iPSCs) co-cultured with mesenchymal and
endothelial progenitors, and allows
for the growth of a small vascularized and functional organ [1 - 3].
Cardiovascular disease and renal disease
for example are accelerated in patients with diabetes and AGEs have been shown to induce senescence in
cell types related to these diseases, such as
endothelial progenitor cells, vascular
endothelial cells and renal
cells.
Direct conversion or reprogramming of human postnatal
cells into
endothelial cells (ECs), bypassing stem or
progenitor cell status, is crucial
for regenerative medicine,
cell therapy, and pathophysiological investigation but has remained largely unexplored.
There have, however, been some studies with encouraging results;
for example, Chinese scientists took human
endothelial progenitor cells exposed to resveratrol, and showed that telomerase activity increased.
As
for the average American, no one is going to forego supersizing their hasty meal because of Neu5Gc, IGF - 1,
endothelial progenitor cells, telomere length, mTOR or TMAO.