Sentences with phrase «for epidermal»

Current studies focus mainly on two receptor systems - the mast cell surface receptor, FcεRI, and the receptor for epidermal growth factor that operate in immunological and cell proliferation responses.

For epidermal cells, the last cell before the hair cell was the one measured as lmax.

Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation.

Derivation of pluripotent stem cells, either of embryonic origin or following genetic reprogramming, has opened the path for an alternative source for epidermal cell therapy as these cells are both immortal and pluripotent, theoretically capable of providing any requested number of cells of any desired phenotype.

Alice Shaw recalls a signal moment in 2004 — just as she was finishing her oncology fellowship at MIT — when scientists discovered that mutations in a gene for epidermal growth factor receptor (EGFR) were the culprits in about 10 to 15 percent of lung cancer patients.

The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.

Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker - guided treatment is cost - effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer (NSCLC) setting in the United States.

Not exact matches

Yet for Updike consciousness itself is epidermal.

Findings of the research, published April 22 in the journal Mucosal Immunology, reveal that a substance found in animal and human breast milk called epidermal growth factor, or EGF, blocks the activation of a protein responsible for unlocking the damaging immune cascade that culminates in NEC, a disease marked by the swift and irreversible death of intestinal tissue that remains one of the most - challenging - to - treat conditions.

About 15 to 20 % of breast cancers are classified as «triple negative,» so called because these tumors do not express three key proteins that are biomarkers and / or drug targets for breast cancer: the estrogen receptor, the progesterone receptor, and HER2 (a member of the epidermal growth factor receptor family).

Recent findings suggest a novel positron emission tomography (PET) imaging approach determining epidermal growth factor receptor (EGFR) mutation status for improved lung cancer patient management.

Dr Dusko Ilic, leader of the team at King's College London, says: «Our new method can be used to grow much greater quantities of lab - grown human epidermal equivalents, and thus could be scaled up for commercial testing of drugs and cosmetics.

For example, epidermal growth factor (EGFR) mutations may result in sensitivity to drugs that are EGFR tyrosine kinase inhibitors (TKIs), such as erlotinib or gefitinib, whereas individuals with the EGFR T790M mutation are more resistant to these drugs.

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the preferred treatment option for patients with advanced non-small cell lung cancer (NSCLC) who have mutations in the EGFR gene.

Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well - known «resistance» mutations in the gene called epidermal growth factor receptor (EGFR).

Triple - negative cancers are so called because they do not express receptors for the hormones estrogen and progesterone, nor for HER2 (human epidermal growth factor 2), and hence patients with these cancers are not candidates for treatment with modern hormonal therapies or the highly effective HER2 - targeted drug Herceptin (trastuzumab).

For years researchers have been developing molecular imaging techniques that visualize hormonally active breast cancer cells — specifically those testing positive for human epidermal growth factor receptor 2 (HERFor years researchers have been developing molecular imaging techniques that visualize hormonally active breast cancer cells — specifically those testing positive for human epidermal growth factor receptor 2 (HERfor human epidermal growth factor receptor 2 (HER2).

PALLAS: Palbociclib Collaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR +) / Human Epidermal Growth Factor Receptor 2 (HER2)- Negative Early Breast Cancer

Human epidermis has been produced in vitro for decades using adult epidermal stem cells from donors to provide cell therapy.

With this technology, they could watch for responses as cancer cells responded to signals from EGFR (epidermal growth factor receptor).

GEP testing is recommended for patients with early - stage, node - negative, estrogen receptor (ER)-- positive, human epidermal growth factor 2 (HER2)-- negative cancers.

Title: Capturing epidermal stemness for regenerative medicine Authors: Barrandon Y, Grasset N, Zaffalon A, Claudinot S, Lathion Droz - Georget S, Nanba D, Rochat A Date: 2012 Publication Details: Seminars in Cell & Developmental Biology 2012 Oct 2.

A major challenge for assessing driver mutations, such as epidermal growth factor receptor (EGFR) mutations, in advanced disease is the scarcity of suitable biopsy tissue for molecular testing.

Each subtype was classified by gene expression clustering, and showed specific patterns of genetic alterations, particularly for four genes: platelet - derived growth factor receptor alpha (PDGFRA), isocitrate dehydrogenase 1 (IDH1), epidermal growfth factor receptor (EGFR), and neurofibromin 1 (NF1).

Chemotherapy is a key part of the standard treatment regimen for triple - negative breast cancer patients whose cancer lacks expression of estrogen and progesterone receptors and the human epidermal growth factor receptor 2...

Epidermal beta catenin activation stimulates expansion of the upper dermal lineage, rendering wounds permissive for hair follicle formation.

Morphologically, the DZ in the wild type (WT) is marked by the appearance of epidermal root hairs on the external surface of outer cell files (trichoblast) and the existence of fully differentiated xylem for internal cell files (Dolan et al, 1993; Ishikawa & Evans, 1995; Beemster et al, 2003; Verbelen et al, 2006; Zhang et al, 2010; Mähönen et al, 2014).

Triple negative breast cancer is a type of breast cancer that does not express receptors for the hormones estrogen and progesterone, or for human epidermal growth factor.

The human epidermal growth factor receptor - 2 (HER2) gene makes proteins responsible for maintaining healthy cell growth, division and repair of breast tissue.

In addition to RIPK2 binding as part of this computer - based (initial) screening, we selected compounds that inhibited epidermal growth factor receptor (IC50 values > 1000 nM; weak inhibitory activity) along with weak binding interactions in the EGFR and c - ABL binding sites, two common off - targets for previously identified RIPK2 inhibitors.

The discovery of how the epidermal growth factor receptor (EGFR) is activated offers insight into how current EGFR - blocking drugs interact with the receptor and an important avenue for the...

Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis.

These results, also presented at the 2015 European Cancer Congress (ECC2015, abstract # 5BA) today, which involve the group of 1,626 patients with a Recurrence Score between 0 and 10, demonstrated that 99.3 percent of node - negative, estrogen receptor (ER)- positive, human epidermal growth factor receptor 2 (HER2)- negative patients who met accepted guidelines for recommending chemotherapy in addition to hormonal therapy, had no distant recurrence at five years after treatment with hormonal therapy alone.

Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice as likely as white women to have triple - negative breast cancer — so called because tumor cells in this particularly aggressive form of the disease test negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER - 2).

Peptide growth factors are constantly present in the gastrointestinal tract, being secreted by glands; for example, Epidermal Growth Factor (EGF) from the salivary glands, or ingested in foodstuffs such as milk and colostrum.

Excessive activation of lymphocytes (a form of white blood cells) are thought to be responsible for the short epidermal cell cycle that results in hyperproliferation of skin tissues.

More than 3,000 years of recorded use, as well as modern clinical research in both humans and animals, suggest a wide range of potential applications for BLACK CUMIN SEED OIL ORGANIC - from helping to balance the gut microbiome to benefitting epidermal structure and appearance.

Skin epidermal barrier function is critically important to our skin at any age, and the breakdown of this barrier for any reason causes problems such as rashes, eruptions, dry skin, and poor wound healing.

To enhance lip plumpness and contour, look for lip treatments that boost collagen production and increase epidermal water content.

The levels of omega 6: omega 3 are critical for the development and regulation of epidermal barrier integrity and sebum formation.

It is a vital epidermal protein that is needed to develop corneocytes and for the generation of intracellular metabolites that modulate the hydration and pH of the skin.

Together with potassium and sterolins, these nutrients encourage epidermal cell turnover, making the oil ideal for anti-aging products, dry skin formulations and as a treatment for damaged skin cells and a range of skin conditions that include eczema and psoriasis.

Omega 3 fatty acids and in particular the long chain variety EPA and DHA and the omega 6 fat GLA are critical for improving epidermal function and reducing skin related inflammation.

When used on the skin, alpha hydroxy acids help other cosmetic compounds penetrate more effectively and rapidly, absorbing deep into the skin's epidermal layers, for more effective and noticeable results.

Even if one makes allowances for the comic book aspects of the story and the required suspension of disbelief, there is something ludicrous, to put it mildly, about the assertion that seeing an African king possessed of superhuman strength and agility back - flipping across the screen speaks in some profound way to the situation facing the masses of people, black, white or any other epidermal pigmentation.

For example, a pet - friendly measure of skin health was developed (trans - epidermal water loss) which involved parting the hair on the dog s back and placing a probe against the skin.

Firstly, 27 nutritional components were screened in vitro for their ability to up - regulate epidermal lipid synthesis, using cultured canine keratinocytes (Watson et al. 2006).

In highly proliferative lesions with increased Ki67, estrogen receptor was negative, but human epidermal growth factor receptor 2 was usually positive with a distribution that was similar to that reported for human intraepithelial lesions (7).

The other grant goes to Sheila Torres, BS, DVM, MS, PhD, DACVD, and Lucy Vulchanova, BS, PhD, of the University of Minnesota College of Veterinary Medicine, for their proposal titled, «A new drug target for improved epidermal barrier function in atopic dermatitis.»

A wonderful and safe therapy for allergies involves finding out precisely what a pet is allergic to and then taking small amounts of those pollens, molds and epidermal agents and giving regular allergy shots to reduce the body's sensitivity and allergic symptoms.