Sentences with phrase «for epigenetic modifications»

However, 15,627 CpG sites in / near ∼ 30 % of all genes exhibited differential methylation in adipose tissue from a case - control cohort of unrelated individuals, supporting a key role for epigenetic modifications in T2D patients.

As a result, S - adenosyl methionine was available for these epigenetic modifications that are required for a cell to enter the primed state.

This briefing enabled journalists to find out about molecular genetic techniques for genome editingand tools for epigenetic modification.

Not exact matches

Chemical modifications such as DNA methylation control mammalian genes, serving as bookmarks for when a gene should be used — a phenomenon known as epigenetics.

Professor Keith Godfrey, from the Medical Research Council Lifecourse Epidemiology Unit and the National Institute for Health Research Southampton Biomedical Research Centre, and a member of the study team, said: «The new findings provide the first direct evidence linking faltering of a baby's growth in the womb with epigenetic modifications that themselves may increase the risk of childhood obesity.

De Assis, who presented the work at the American Association for Cancer Research meeting in Washington DC, says a fatty diet may cause «epigenetic» DNA modifications that can be passed on to future generations.

Scientists of the German Center for Diabetes Research (DZD) led by the German Institute of Human Nutrition (DIfE) have shown in a mouse model that the epigenetic * modification of the Igfbp2 ** gene observed in the young animal precedes a fatty liver in the adult animal later in life.

Corin is particularly attractive as an inhibitor of epigenetic modifications because it has dual - target specificity which allows for more selective targeting of epigenetic complexes in treated cells.

«For example, we now know that RNA can be methylated just like DNA and in a highly specific way,» says Dr. Manel Esteller, «and even more recently we observed that these epigenetic modifications of RNA may be key in the regulation of «guardian» RNAs, also called non-coding RNAs.»

The researchers linked the excess weight and changes in metabolism to epigenetic modifications that reduce expression of the gene for adiponectin — a hormone that helps regulate several metabolic processes, including glucose regulation.

The differences between male and female iPS cells are most pronounced for one of the key processes in the field of epigenetics: DNA methylation, a modification that changes the activity of a DNA segment without changing its sequence.

Stroud was interested in studying epigenetic changes, or chemical modifications that turn genes on and off, in DNA for the glucocorticoid receptor gene that regulates passage of cortisol from mother to fetus.

Researchers based at Rice's Center for Theoretical Biological Physics (CTBP) have constructed computer models to analyze epigenetic marks, which include proteins bound to DNA as well as chemical modifications to histone proteins.

Recent studies have expanded the search for genetic links from identifying genes toward epigenetics, the study of factors that control gene expression and looks at chemical modifications of DNA and the proteins associated with it.

So what we think is that probably in many cells in this section, all cells, the chromatin is encountered in a specific state, and in order to render the cell is permissive to reprogramming, you have to overcome these certain epigenetic modifications that block, for example, the binding of Ascl1 to its target chains, or the binding of other transcription factors to its target chains, then this way interfere with the possibility of reprogramming.

Indeed epigenetic DNA modifications are inherited through cellular replication and errors in their positioning might be lethal for the cells and the pathways that are related to them.

If you want to study the effects of one particular modification for which a targeted editor, like H3K27ac, is available, an epigenetic tool would be your best bet.

We focus on the 5hmC epigenetic modification and have a patent protected platform for detection of highly accurate signatures for a variety of diseases using this mark.

We found that genes within islands of differentiation were enriched for several functional classes (Table S4), and most terms were related to transcription and epigenetic pathways (e.g. chromatin organization and modification, regulation of transcription and translation, DNA binding).

Epigenetics are modifications on top of the DNA sequences and regulate expression of the DNA within each cell of the body as required for normal development and functioning.

Epigenetic marks, such as the modifications of the histones, are also important for the specialisation of the body's cells.

These alterations, technically called epigenetic modifications, can be transmitted from mother to child for generations.

«Many of the carcinogens present in mainstream smoke are known to exert their effects through a genotoxic mode of action, which is based on their ability to induce DNA damage and mutations, although an epigenetic mode of action, e.g., through aberrant DNA methylation and histone modifications, is also beginning to emerge for a few of these carcinogenic compounds.»

Epigenetic modifications of promoter regions that influence the transcription of genes coding for crucial protein products can be induced by the environment.