Sentences with phrase «for epigenetic regulation»
«Our findings suggest that molecular mechanisms for epigenetic regulation within the spinal cord constitute the starting point for handedness,» said Ocklenburg from Ruhr University Bochum in Germany.
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The evidence for epigenetic effects on emotion regulation is quite solid: Early caregiving experiences can affect the expression of the genes that regulate a baby's stress and they can shape how the endocrine system will mobilize to stress.
«These new insights into the complexities of epigenetic regulation are contributing to our basic understanding of this process in human health and disease and gives us new vision for how to go about targeting errors in DNA methylation with innovative drug therapies.»
For 50 years, the fundamental principles and mechanisms of the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.
«For example, we now know that RNA can be methylated just like DNA and in a highly specific way,» says Dr. Manel Esteller, «and even more recently we observed that these epigenetic modifications of RNA may be key in the regulation of «guardian» RNAs, also called non-coding RNAs.»
Rather the opposite was true, the altered epigenetic regulation of the gene was responsible for the development of the fatty liver,» added Sophie Saussenthaler, who shared the first authorship with Baumeier.
The researchers linked the excess weight and changes in metabolism to epigenetic modifications that reduce expression of the gene for adiponectin — a hormone that helps regulate several metabolic processes, including glucose regulation.
Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).
We have known for some time that it's not only the sequence of the DNA that is important; the physical scaffold, organization, and regulation of the DNA is also key and is known as epigenetics.
Participating institutions: Helmholtz Association • CNRS • Institute of Molecular Biotechnology • Research Center for Molecular Medicine of the Austrian Academy of Sciences • VIB - KU Leuven • Friedrich Miescher Institute for Biomedical Research • University of Basel • University of Zurich • Central European Institute of Technology • Max Planck Institute of Immunobiology and Epigenetics • Max Planck Institute for Molecular Genetics • German Cancer Research Center • Max Delbrück Center for Molecular Medicine • German Center for Neurodegenerative Diseases • Helmholtz Zentrum München • Max Planck Institute for Evolutionary Anthropology • Helmholtz Institute of RNA - based Infection Research • Saarland University • Technical University Munich • University of Würzburg • Biotech Research & Innovation Centre • Interdisciplinary Nanoscience Center • University of Copenhagen • Centre for Genomic Regulation • Institut Curie • Université de Montpellier • Inserm • Université Toulouse III — Paul Sabatier • École nationale supérieure des mines de Paris • Institute for Molecular Medicine Finland • The Biomedical Research Foundation, Academy of Athens • Weizmann Institute of Science • Hebrew University • Sapienza — University of Rome • Instituto Nazionale Genetica Molecolare • University of Napoli • University of Padua • University of Milan • European Institute of Oncology • Netherlands Cancer Institute • Radboud University • University Medical Center Utrecht • Hubrecht Institute • Instituto Gulbenkian de Ciência • Institute of Bioorganic Chemistry of the Polish Academy of Sciences • Romanian Center for Systems Immunology • Karolinska Institute • MRC Human Genetics Unit • University of Edinburgh • Wellcome Sanger Institute • The Babraham Institute • European Molecular Biology Laboratory — European Bioinformatics Institute
We found that genes within islands of differentiation were enriched for several functional classes (Table S4), and most terms were related to transcription and epigenetic pathways (e.g. chromatin organization and modification, regulation of transcription and translation, DNA binding).
The gene content of these regions, which in several cases reached gene - level resolution, suggests an important role for epigenetic and transcription regulation in the maintenance of reproductive barriers.
This observation and the availability of a reference rabbit genome allowed us to identify several candidate genes for reproductive isolation in this system that suggest an important role for epigenetic and transcription regulation in the maintenance of reproductive barriers.
Xu is developing computational algorithms for the design and analysis of high - throughput biological experiments with a focus on applications in transcriptional and epigenetic gene regulation.
These observations, which have provided striking insights into the epigenetic regulation of the molecular blueprint for pluripotency within ES cells, have been made at the population level, and thus reflect the summation of activity within all cells in the population.
Epigenetic gene regulation is important for both normal development and disease states.