Sentences with phrase «for epigenetic therapy»
The basic idea for epigenetic therapy is to focus on how cancer cellsâ $ ™ DNA is wrapped instead of the mutations in the DNA.
http://www.emoryhealthsciblog.com/ Not exact matches
«These new insights into the complexities of epigenetic regulation are contributing to our basic understanding of this process in human health and disease and gives us new vision for how to go about targeting errors in DNA methylation with innovative drug therapies.»
«It is expected that this study will lay the foundation for developing a new class of potent and effective cancer therapies and the development of reagents targeting epigenetic events in immune - mediated diseases as well as other epigenetically - influenced diseases,» said Alani, who also is chief of dermatology at Boston Medical Center.
The researchers were able to reverse these epigenetic changes with the use of an FDA - approved drug, forcing the cancer cells out of hiding and potentially making them better targets for the same immune therapy that in the past may have failed.
Epigenetic therapies are rapidly being developed as cancer treatments, opening the possibility to also test these drugs for antiviral activity.
«Multiple epigenetic regulators participate in the drug - desensitizing pathway, so they could serve as new targets to improve therapy for this type of cancer.»
This is both a useful tool for giving us a better understanding of the genetic and epigenetic program controlling the self - renewal of stem cells, and on a practical side, it could allow us to inexpensively produce large numbers of immune cells, which could then be used for regenerative medicine or immune therapy.»
While both studies are bad news for many women, Horvath suggests that scientists in the future may use the epigenetic clock as a diagnostic tool to evaluate the effects of therapies, like hormone therapy for menopause.
Understanding these pathways, and the identification of the key proteins that control the ability of cancer cells to reprogram their metabolism through biochemical, and epigenetic or genetic alterations that make them resistant to therapies, is of paramount importance for the design of more targeted and therefore less toxic therapies.
Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above human MLSP of around 122 years; thus these therapies do not affect epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MLSP).
Such epigenetic mechanisms have already been exploited for diagnosis and treatment; for example, DNA hypomethylation therapy with 5 - azacytidine is approved for MDS and is in clinical trials for some other cancers.
For example, the discovery of cancer - causing genetic and epigenetic changes in tumors has enabled the development of therapies that target these changes as well as diagnostic tests that identify patients who may benefit from these therapies.
Increased understanding of epigenetic disease mechanisms, including natural and anthropogenic environment factors, could lead to disease risk stratification for targeted intervention and to targeted therapies.
Increased understanding of epigenetic disease mechanisms could lead to disease risk stratification for targeted intervention and to targeted therapies [6].
c. Epigenetic approaches to primer for and / or synergize with immunological therapy in epithelial ovarian cancer.
Ultimately, the Epigenetics team will work to develop another set of clinical trials for a second - generation epigenetic therapy that will more effectively and directly inhibit the specific epigenetic mistakes associated with cancer causation.
In particular, Dr. Azad's laboratory and clinical trials explore epigenetic therapy in combination with chemotherapy and immunotherapy to improve survival for patients, as well as molecularly targeted drugs.
Understanding epigenetic mechanisms and their contribution to the persistence of diabetic complications is critical because it could suggest alternative targets for therapy to halt and reverse complications.
«This offers the opportunity for development of epigenetic targeted therapies for patients with ALL that could be broadly applicable to many patients.»
«If we can reprogram this epigenetic mechanism, then the therapy might work for more patients,» says Zou, Charles B. de Nancrede Professor of Surgery, Immunology and Biology at the University of Michigan Medical School.
«If the pilot trial is successful, we plan to pursue a larger trial to explore this strategy's potential as a straightforward and cost - effective way to improve the existing therapy for AML and MDS,» said Peter Jones, Ph.D., D.Sc., co-senior author of the PNAS study, chief scientific officer at Van Andel Research Institute (VARI) and co-leader of the Van Andel Research Institute — Stand Up To Cancer (VARI — SU2C) Epigenetics Dream Team.
While many of today's tools were not yet available in 1991, IFM was already focused on using this emerging knowledge to adapt therapies to the patient (rather than the reverse) by training clinicians to examine the genetic and epigenetic factors for each patient and to develop an individualized therapeutic approach that addresses these underlying factors.
Dr. Cortés has been training dentists in the field of epigenetics orthopedic and orthodontic therapy in the reversal of sleep breathing disorders for adults and children from 2012 — present.
Responding to his / her exhibited video work «epigenetic therapy treatment» Mputu offers a healing workshop and performance in which the artist engages directly with participants to put forward tools for physical and emotional healing.