Sentences with phrase «for epithelial cell»

These live microorganisms have proven health benefits and well - established safety, and have been tested for epithelial cell adhesion and / or resistance to low pH.

Not exact matches

Vitamin A also maintains epithelial cells, which are responsible for keeping body surfaces healthy so that they can act as barriers to infection.

The strict definition of celiac disease — positive antibodies to gliadin, intestinal endomysium, and tissue transglutaminase, together with the presence of HLA - DQ2 or HLA - DQ8 genes and an intestinal biopsy that shows at least 20 - 25 CD3 cells per 100 epithelial cells — will account for about 75 - 80 % of all those sensitive to gluten.

Secretion of the hormones estrogen and progesterone set the stage for dramatic changes that take place in the breast during pregnancy: a massive proliferation of mammary epithelial cells, and the formation of thousands of ductal structures, which support milk production and transport during lactation.

While abnormal immune responses are largely responsible for these diseases, issues relating to gut microbiome, intestinal epithelial cells, immune components and the gut's rhythmic peristalsis motions can also contribute to and exacerbate symptoms.

He determined that epithelial cells lining the brain's blood vessel walls contain a surface protein, or receptor, that can snag insulin, the hormone essential for metabolizing carbohydrates and fats.

Researchers showed that flu infection changed the metabolism of human lung epithelial cells, the prime location for replication of flu virus.

Part of the cytoskeleton, vimentin gives flexibility and structure to the cell, but it is also a marker of epithelial - mesenchymal transition (EMT), which is considered a crucial event for metastasis in epithelial tumors.

In those cells the Esrp1 and Esrp2 proteins enforce epithelial - specific splicing isoforms for hundreds of different genes, as Carstens and his team have shown in studies since 2009.

People infected with HIV have few signs of microbial translocation during the first six months of infection as it takes time for the virus to kill off epithelial cells and weaken the gut wall so that bacteria can leak through — so treating them early could be more effective.

The study, which followed four individuals for a year after they were treated with embryonic stem cell - derived retinal pigment epithelial cells for macular degeneration, observed no serious side effects (tumor growth or other unexpected effects) related to the therapy.

Recently published in the journal eLife and featured in a poster session at this year's American Association for Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition (EMT).

«The first thing that needs to happen for wound healing is to activate the migration of epithelial cells,» Oudhoff says.

Researchers at the RIKEN Center for Developmental Biology in Kobe plan to generate replacement retinal pigment epithelial cells from iPS cells generated from patients suffering age - related macular degeneration.

The images show how a growth factor caused cells to change forms and regroup from tight packs of epithelial cells to more mobile, loose arrays of mesenchymal cells — information useful for studying cancer and wound healing.

«Two components of the pathway, the phosphatase PTPD2 and the lipid PA, are together required for HER2 signaling to function in mammary epithelial cells.»

Similar patches have already had some positive results for the «wet» form, in which blood vessels invade and destroy the retinal pigment epithelial cells.

To test their idea for the dry form, Amir Kashani of the University of Southern California in Los Angeles and his colleagues coated 6 by 4 - millimetre slithers of polymer with retinal pigment epithelial cells they had grown, then transplanted these into four people.

It has been designed for treating the «dry» form of macular degeneration, caused by deposits on the retina gradually killing retinal pigment epithelial cells, which support light - capturing cells.

As an important prerequisite for tube formation, epithelial cells become asymmetric or «polar», acquiring structurally and functionally distinct ends or surfaces.

«It is an important physiological mechanism for the ordered removal of cells from the epithelial layer, but when it is out of control has profoundly damaging effects,» said Campos.

During pregnancy, the elevated blood estrogen level induces the proliferation of mammary epithelial cells, leading to the development of the mammary gland in preparation for lactation.

Xiaowei «George» Xu, MD, PhD, associate professor of Pathology and Laboratory Medicine and Dermatology at the Perelman School of Medicine, University of Pennsylvania, and colleagues published in Nature Communications a method for converting adult cells into epithelial stem cells (EpSCs), the first time anyone has achieved this in either humans or mice.

His recent published work describes the rescued visual function in animals using retinal pigment epithelial cells derived from human embryonic stem cells and a method for deriving stem cells using a single - cell approach that does not harm embryos.

First, the MimEX ™ Cell Plating Procedure is used to maintain a uniform irradiated fibroblast monolayer for the rapid clonal expansion and efficient differentiation of tissue - specific adult epithelial stem cells.

MimEX ™ Tissue Models System provides a platform for the isolation, expansion, and differentiation of adult epithelial stem cells into 3 - D ex vivo organ tissue.

This video provides an overview of MimEX ™ Tissue Model Systems, a next - generation 3 - dimensional (3 - D) cell culture platform for the generation of ex vivo epithelial - derived organ tissue.

A549 lung epithelial cells grown as three - dimensional aggregates: alternative tissue culture model for Pseudomonas aeruginosa pathogenesis.

Leveraging these technologies, the team generated expression profiles for a total of 53,193 small intestinal epithelial cells.

Using Cultrex ® BME, MimEX ™ Tissue Models System provides a platform for the isolation, expansion, and differentiation of adult epithelial stem cells into 3 - D ex vivo organ tissue.

Spleen cells were isolated 7 — 14 days after C57BL / 6 CD4 KO mice had rejected BALB / c corneal allografts and were tested for anti - BALB / c CTL in a conventional 4 - hr 51Cr - release assay using BALB / c corneal epithelial and endothelial target cells.

We are interested to understand the molecular mechanisms deployed by Salmonella for invasion of polarized epithelial cells.

Thirdly, the current, almost universal dependency of organoid culture on the use of Matrigel as a replacement for the function of the extracellular basement matrix in providing structural support and survival signals to the epithelial cells hampers clinical application, considering its origin from a mouse sarcoma cell line, its poorly defined composition and its mechanical rigidity after plating.

«The new protein plays a key role in the formation of adherens junctions of epithelial cells, and Listeria uses it for its own infectious process.»

It results from the death of cells critical for vision: retinal pigment epithelial cells (RPE) and photoreceptor cells.

ARHGAP21 Protein, a New Partner of α - Tubulin Involved in Cell - Cell Adhesion Formation and Essential for Epithelial - Mesenchymal Transition.

Protocols to grow organoids as polarized monolayers of epithelial cells on membranes or filters are already in place for the intestine, gall bladder, liver and pancreatic ducts (21).

Inside the epithelial cell, the tail of E-cadherin binds to a protein called α - catenin, which recruits other proteins that spur assembly and disassembly of actin filaments and is absolutely critical for strong adherence between epithelial cells.

First, most currently generated organoids mainly contain epithelial cells and are void of the many different cell types that are essential for the morphology and functionality of the whole organ.

So far, two major endogenous cell sources for neuronal regeneration have been described: the Müller glia (MG) and retinal pigment epithelial (RPE) cells.

Differentiation of the mammary epithelial cell during involution: implications for breast cancer.

With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.

MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three - dimensional culture.

Here we describe a method for fabricating a primary human Small Intestine - on - a-Chip (Intestine Chip) containing epithelial cells isolated from healthy regions of intestinal biopsies.

Furthermore, there was a negative expression for Cyclin D1 protein in normal ductal epithelial cells, while the benign group revealed week positivity immunostaining Cyclin D1 in 60 %, whereas, the malignant group represented a variable positivity of immunostaining scores; they were classified as 3 (10 %) cases were weak, 9 (30 %) moderate cases and 12 (40 %) strong expression cases.

It has been observed for nearly 80 years that Bps can change colony morphology, and recent studies have shown an association between morphotypes and specificity for body compartments, ability to adhere and penetrate epithelial cells or macrophages, and expression of virulence factors.

Smyd3 function is required for the activation of oncogenic pathways, cell proliferation and epithelial to mesenchymal transition during tumorigenesis.

In the vaccine comparison experiment, lung lesion scores for histopathology were graded for individual animals on a scale of 0 to 4 where 0 — 2 represented degree of cellular infiltration and 3 — 4 represented the degree of bronchiolar epithelial cell necrosis and airway cellular debris (figure 2A).

Saliva is often collected for genotyping studies but is rarely used to examine DNA methylation because the proportion of epithelial cells and leukocytes varies extensively between individuals.

Limbal epithelial stem cells sheets cultured on amniotic membranes for treatment of limbal stem cell deficiency (LSCD).