Sentences with phrase «for funding decrease»

Today if one's proposal lacks a disease as a focus, the chances for funding decrease (the Proxmire effect).

Not exact matches

In the first quarter of 2013, for example, U.S. venture capital firms raised $ 2.9 billion from 44 funds — a decrease of 33 percent compared to the same quarter last year, according to the NVCA and Thomson Reuters.

As interest rates for these seemingly safer investments increase, they become more attractive to investors, and as such, the incentive for investors to plow funds into high - risk opportunities decreases.

The White House has proposed a $ 1.2 billion funding cut to the NIH for just 2017, and more wide - ranging decreases down the line.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

While it's always interesting to know about the top runners, renewable energy companies in various growth stages will become more important as government funding for research and development related to energy efficient, emissions reduction and carbon capture decreases.

During periods of difficult market conditions or slowdowns in these sectors or geographic regions, decreased revenue, difficulty in obtaining access to financing and increased funding costs experienced by our funds may be exacerbated by this concentration of investments, which would result in lower investment returns for our funds.

The press release claimed, «For the first time in over a decade, funding needed to sustain the federal government has decreased.

Once your loan is 100 % funded, you can accept it to get the funds sooner or wait for any further bids that could decrease the interest rate you pay.

In January we saw a huge value decrease in our funds for the first time ever, due to the bonds getting slammed for the month.

When business goals for a startup are clearly stated in «milestone» achievements that coincide with funding, VCs are more likely to take an interest, since the investment risk is decreased.

After surveying our membership about the proposed changes to the taxation of CCPCs and how they might affect the availability of capital and active Angel support for entrepreneurs, we found that possible outcomes include decreased incentive and capital for Angels to invest and decreased access to early - stage capital, which may adversely influence the flow of funds and resources to Canadian entrepreneurs.

The Board also considered that the Fund's total net assets will decrease as a result of the Initial Tender Offer (and the Conditional Tender Offer, if conducted), which may result in greater volatility, less investment flexibility and proportionately higher expenses for the Fund's remaining shareholders following the Tender Offers.

As a result, while we decreased our exposures as these currencies weakened, the currencies for which the Fund has hedged were the same as the previous quarter.

By tapping your Roth account before your taxable account, you decrease the amount of distributed funds you'll pay tax on for that year.

The same is true of UN Capital Development Fund's Christine Roth's claims that electronic payments «decrease the costs of the transactions» and are «a safer way for recipients to access money.»

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

The repudiation of odious debts would be an act of independence by the debtor nations that could greatly decrease the power of the World Bank and the International Monetary Fund to shape their economies for the sake of greater profits and power for transnational corporations.

In his seven years as president, President Houshmand has implemented many programs and initiatives to decrease the cost of higher education, including creating a $ 25,000, four - year bachelor's degree program, awarding more than $ 27 million annually in scholarship funds and waivers, and committing to capping tuition and fee increases at or lower than the rate of inflation for his tenure.

Mr Newnham said while he expected the property values to rise he wanted the fund to be recognised more for its strong cash profits rather than the variable statutory profit that includes the increase or decrease in the value of properties.

Rural Funds Group's investments in cattle and cotton follows a decrease in demand for almond plantings (which still account for almost half of its portfolio by value) after California, the world's biggest almond growing region, lifted production following many years of drought.

One of the changes administrators made in the new budget was to decrease funding for capital projects by about 26 percent to around $ 2.2 million from $ 2.8 million from previous year, documents show.

This particular meta - study reported that breastfeeding provides up to a 28 % decrease in risk of developing breast cancer at any age (pre - or post-menopausal) for women without a family history of the disease, who breastfed for 12 months or longer (World Cancer Research Fund and American Institute for Cancer Research, 2007).

Although the decrease is considerable, the IRGC's budget in 2013 - 14 clearly shows that the funding allocated is sufficient to cover all its costs, except for foreign expenses.

For an example of the latter, the Finnish working group coordinated by Kela found that Finnish support for basic income decreased quite radically once questions about the amount of basic income are paired with corresponding questions about the taxes needed to fund For an example of the latter, the Finnish working group coordinated by Kela found that Finnish support for basic income decreased quite radically once questions about the amount of basic income are paired with corresponding questions about the taxes needed to fund for basic income decreased quite radically once questions about the amount of basic income are paired with corresponding questions about the taxes needed to fund it.

With mounting delays, aging equipment, a troubling ridership decrease, and fare hikes on the horizon, it would seem an especially bad time for the state to pull back funding for the MTA.

They can only do this for healthcare - related appropriations, and only if it does not increase the deficit (meaning that without any other shenanigans, they can only decrease funding).

Point of reference: Last year, the executive budget proposal was $ 134 billion (all funds), or $ 3.7 billion less than this year for a 2.3 percent decrease.

«We were also in a year in which we were planning to decrease our fund balance and had put that into the budget so it was sort of a double whammy for us.»

Off topic questions included a Department of Investigations report detailing problems with corrections officers at Rikers Island, de Blasio's message to protestors resuming anti-NYPD protests, his relationship with police unions, a call by the head of the Lieutentants Benevolent Association to strengthen laws concerning resisting arrest, an increase in police protection for Jewish organizations and sites and Dov Hikind's claim of a decrease in police presence, delays in the implementation of the City's municipal ID card program, his message to PBA members dissatisfied with their union leadership, his position on a city council plan to fund the purchase of additional bullet - proof vests for police officers, whether the Democratic National Committee has expressed concerns around the recent protests as it considers whether to hold the 2016 convention in Brooklyn, whether his «thoughts» on the anti-NYPD protests have «evolved» and whether he will direct the NYPD to change its FOIL request process to accept email or other electronic requests.

Residents can expect to see a decrease in taxes for the second year in a row and more funding for the fight against the county's growing epidemic of drug abuse.

In contrast, dedicating $ 125 million for health care capital grants may prove worthwhile if such funds are utilized to effectuate systematic reforms that lead to improved care with decreased State costs.

«These proposed cuts raise some immediate concerns about affordability, as colleges and universities will need to account for decreased funding.

6) Although new licenses would create an influx of funds for the state immediately, since the gross number of active licenses would ultimately drop by virtue of stores closing, the long term annual income from renewing these licenses would actually decrease.

She said increased funding for positive alternatives for the 2010 - 2011 school year has already led to a decrease in the rate of suspension.

The employer contribution rates for the state pension fund in the coming 2016 - 17 fiscal year will once again decrease, but so will the assumed rate of return for the fund overall, Comptroller Tom DiNapoli on Friday announced.

The budget has a slight decrease in property taxes, but there will be funding to redevelop the former Bethlehem Steel site and increased funding for infrastructure.

She noted that while transit across upstate can expect a 1 percent increase in operating assistance in 2018 - 2019, funds for NFTA capital projects will decrease by $ 2.2 million in the authority's $ 234.2 million budget.

This year, the threat of decreased state funding for CUNY, as outlined within Governor Andrew Cuomo's 2016 budget, was the central topic at the annual gathering held on Thurs., Feb. 25th at the office of Manhattan Borough President Gale Brewer.

The administration also got a lifeline from the city's Independent Actuary's office, which has recommended decreasing the rate of return for the city's pension investment fund from 8 to 7 percent.

After increasing for many years and reaching a peak of $ 135 Million for Yonkers in 2009, AIM funding has now decreased to $ 108.2 Million.

While the general mood in the room was one of cautious optimism about the Republican - led legislature's willingness to fund arts and culture at the recommended levels, there remained a possibility that the majority's professed desire for a tax decrease might eat away at the sector's hard - won gains over the past few years.

The Assembly budget addresses those issues and others by doing away with Cuomo's proposed decrease in funding the city receives for its Emergency Assistance to Families program.

A number of expenses are slated for modest decreases in the spending plan — including health insurance costs, liability insurance and fuel costs, among other items — which has reduced reliance on fund balance.

And per - student city funding for the community colleges decreased by 13 percent over the same period, also when adjusted for inflation.

Under provisions of the current continuing resolution, federal research funding would total $ 55.2 billion for FY 2007, a 2.6 percent decrease that would mark the first year - to - year decline in at least three decades.

But for supporters like Hassan, the program's carbon auctions have funded energy efficiency programs that have cut electricity usage and decreased emissions beyond where they would be otherwise.

Buoyed by an allocation of $ 1.25 billion in funding for reactor research from the 2005 Energy Policy Act, INL scientists are working to improve safety, boost efficiency, minimize waste, and decrease cost in a new generation of nuclear reactors.

But the Parliament sided with universities and research organizations, which said that the flat rate could unfairly decrease their funding levels and asked for the possibility to claim the reimbursement of actual costs in full.

For female scientists, Lundblad alleges, the result has been a vicious cycle in which their lab budgets are squeezed, resulting in a smaller lab staff, decreasing productivity, and thus even greater difficulty in getting funding and further lost productivity.