Sentences with phrase «for gene copy»

Not exact matches

Gene therapy involves the delivery, using a modified virus, of a healthy copy of a gene to make up for one that's deficient in a way that causes diseGene therapy involves the delivery, using a modified virus, of a healthy copy of a gene to make up for one that's deficient in a way that causes disegene to make up for one that's deficient in a way that causes disease.

For Dawkins, by far the most important aspect of biological nature is the ability of certain stretches of DNA («genes») to engender faithful copies of themselves, under conditions that prevail.

I did get tested for the DQ2 gene: I have one copy.

If you're a carrier of a defective gene for a recessive disorder, that means you have one normal copy of the gene from one of your parents and one defective copy from the other.

In order for your child to inherit your recessive genetic disorder, such as cystic fibroisis, sickle cell disease, fragile X syndrome or Tay - Sachs, both the male and the female partner have to pass on their copy of the mutated gene.

Researchers still have much to learn about the imprinting process and the genes involved, Zhang says, but the discovery of a second mechanism for silencing one copy of these genes underscores imprinting's importance.

For a very small number of genes, though, people inherit only one working copy; the other copy is turned off, forever silenced.

This particular founder was born missing the letters A (for adenine) and G (guanine) from the DNA chain at the 185 site on one copy of his or her BRCA1 gene.

About one in 8,000 children is born with some form of SMA in which mutations in both copies of the gene that code for the survival motor neuron (SMN) protein cripples its production.

To account for the remarkable similarity between retrovirus oncogenes and their normal cellular kin, most virologists have settled on the idea that retrovirus oncogenes are copies of cellular genes.

For gene therapies, scientists remove most of the AAV genome, replace it with therapeutic genetic cargo, and inject trillions of copies into the patient.

In this cycle, new gene copies often arise by gene duplication, with the copies persisting or adapting into new roles within the genome for varying lengths of time, or dying off and being lost randomly.

The trial he conducted tested the safety of a therapy for ornithine transcarbamylase (OTC) deficiency, a rare disorder in which the liver lacks a functional copy of the OTC gene.

«For example, among individuals carrying the SNP sequence «TGT» at all three locations on both copies of the gene, 62 percent were blue - eyed,» says Sturm's colleague David Duffy.

For instance, doctors might be able to turn on alternate copies of genes to compensate for missing proteins or to reinvigorate genes that grow sluggish with aFor instance, doctors might be able to turn on alternate copies of genes to compensate for missing proteins or to reinvigorate genes that grow sluggish with afor missing proteins or to reinvigorate genes that grow sluggish with age.

«Analyzing copies of genes offers new treatment possibilities for ovarian cancer.»

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

For example, the genes the microbe uses to copy genetic information from DNA and translate it into proteins are very similar to the ones we use.

The samples were analyzed by liquid chromatography - mass spectrometry (LC - MS) to characterize the metabolite composition («metabolomics»), and biocrust DNA was extracted for shotgun sequencing to measure single copy gene markers for the dominant microbe species («metagenomics»).

Affected family members, the group found, had inherited one or two defective copies of ZIC3, a previously unknown gene that appears to code for a transcription factor — a protein that switches other genes on or off.

Next, they synthesized a gene for making the protein and inserted it into bacteria, which cranked out copies for them to test.

The number of copies of the resistance gene varies among cultivars; a new method, developed by University of Illinois researchers, is able to efficiently quantify this variation for the first time.

And because mouse embryo cells with inactivated copies of BRCA2 are more sensitive to ionizing radiation than normal cells are, «it's a reasonable extrapolation» that breast cancers with mutated copies of the gene may be especially good candidates for radiation therapy.

By comparing the genetic sequences of the mutant and normal flies, the researchers found that the forgetful flies had an inactive copy of a gene that he and his Chilean collaborators dubbed Volado (Vol)-- South American slang for absentminded.

For the dozens of labs at work on the problem, coming up with useful genes, known as transgenes, is not the hard part — it's how to transfer enough copies of the transgenes into free - ranging populations.

The discovery could mean that it will be difficult for researchers to fix mutations in embryos if neither parent has a healthy copy of the gene.

The researchers mated female mice unable to make the receptor for type I interferons to males with one copy of the gene needed to make the receptor.

Doctors gave the patients stem cells containing copies of a properly functioning gene for the enzyme; the babies» immune systems were then able to reconstitute themselves.

After examining eight such families from the Sichuan province of southeastern China, the duo discovered that in two of the families, the parents (who could hear) had one mutated copy of the gene for myosin VIIA.

The gene is silenced because it is on the part of their chromosome they inherited from their mother, and for mysterious reasons our cells use the father's copy of this gene.

They also ruled out other possibilities, including the gene spontaneously mutating back to the normal form, the existence of more than two copies of the hothead gene, or closely related DNA sequences providing a template for repairs.

For example, they revealed that most organisms have two copies of each gene, one from each parent, and that a gene comes in a variety of different forms, or alleles.

In the latest experiments the Mitalipov group focused on snipping out the mutated gene in heterozygous cells — a situation in which there was still a «good» nonmutated copy available for the natural cellular repair systems in the embryo to use as a template for repair after the researchers edited out the problematic one.

By copying the gene for Spo0F (purple) early in the cell - division cycle and the gene for KinA (green) later in the cycle, the bacteria assure that the decision to form a spore or divide is made when DNA replication has completed.

After enriching for CTCs, the researchers analyzed the samples for ALK rearrangements and for an increase in the number of copies of the ALK gene.

One type had the TMC1 gene completely deleted, and is a good model for recessive TMC1 mutations in humans: Children with two mutant copies of TMC1 have profound hearing loss from a very young age, usually by around 2 years.

DNA INVESTIGATION Geneticists examined DNA from more than 10,000 people in Pakistan looking for people in whom both copies of certain genes were nonfunctional.

By comparing proteomic and RNA - sequencing data from people on different exercise programs, the researchers found evidence that exercise encourages the cell to make more RNA copies of genes coding for mitochondrial proteins and proteins responsible for muscle growth.

We screened a total of 394 Amish research subjects for the KCNH7 mutation; 84 of these individuals carried at least one copy of the gene variant, and the lifetime incidence of bipolar spectrum disorders among them was 49 percent (41 people were affected with the disease).

The team integrated three, complementary gene sequencing approaches to look for mutations in tumor cells from SS patients: whole - genome sequencing in six subjects, sequencing of all protein - coding regions (exomes) in 66 subjects, and comparing variation in the number of copies of all genes across the genome in 80 subjects.

Mitochondrial fingerprinting is normally used when the genetic material in a sample is degraded, for while there are only two copies of each nuclear gene in a cell, there are often hundreds of copies of mitochondrial DNA (mtDNA).

Sickle cell disease is a recessive genetic disorder caused by a single mutation in both copies of a gene coding for beta - globin, a protein that forms part of the oxygen - carrying molecule hemoglobin.

Instead phrases like «the scrub jay wants to do this, decides that this is the right time,» and so on, are shorthand for the more correct but cumbersome, «Over the course of evolution, scrub jays who, at least in part through genetically influenced mechanisms, are better able to optimize the timing of their behavior leave more copies of their genes, thus making this attribute more prevalent in the population.»

It can accurately identify those carrying two copies of the APOE4 gene — known to be a severe risk factor for developing Alzheimer's.

Jaume Bertranpetit of the University of Barcelona estimates that the mutant gene has survived for more than 2500 generations, adding strong support to the theory that people carrying one copy of the gene gain some evolutionary advantage from it.

In research published in the Journal of Bone and Mineral Research, Javed, a professor in the UAB School of Dentistry's Department of Oral and Maxillofacial Surgery, used a mouse model with mutations in both copies of the gene for Sp7.

«Plants with one type of glyphosate - resistance mechanism make multiple copies of the target site for glyphosate, a gene called EPSPS.

For instance, the researchers found that an immune system gene called DUSP22A on chromosome 6 was duplicated, but its copy, DUSP22B, is located on chromosome 16.

The point of life, according to evolutionary theorists, is for organisms to pass on copies of their genes to succeeding generations.

When multidrug - resistant malaria was detected, researchers were initially handicapped by the lack of a marker for piperaquine resistance; now, they have one, the presence of multiple copies of the plasmepsin 2 gene.