Sentences with phrase «for gene deletion»

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

Not exact matches

These deletions also may extend to neighboring genes, an event known as «collateral lethality,» which may create new options for development of therapies for several cancers.

«We showed that the deletion of the gene responsible for this pathway can restore the original therapeutic function of the cells,» said Prof. Leor.

The Salk researchers discovered that deletion of the WRN gene leads to heterochromatin disorganization, pointing to an important role for the WRN protein in maintaining heterochromatin.

Those deletions tended to involve genes that affect cilia, cellular structures that are important for signaling and patterning in embryonic development.

For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes — fam57ba and doc2a — in zebrafish and certain brain and body traits, such as seizures, hyperactivity, enlarged head size, and obesity.

Right now, there is no specific treatment for cancers harboring LKB1 or DIXDC1 alterations, but those with a deletion of either gene would likely see results from cancer drugs that target the focal adhesions, says Shaw.

Researchers checked the genomes of 150 patients with schizophrenia and those of 268 healthy people, looking for large duplications and deletions of genetic material that disrupted the function of a gene.

The second group, consisting of Y - chromosomal gene families expressed specifically in testes, may account for infertility among men with Y deletions.

For example, the scientists identified a deletion in one gene called «stargazin» that is required for regulating the transmission of signals between neurons in the braFor example, the scientists identified a deletion in one gene called «stargazin» that is required for regulating the transmission of signals between neurons in the brafor regulating the transmission of signals between neurons in the brain.

One they came upon was Ufd1 (for ubiquitin fusion degradation), which was one of 25 or so genes known to lie within the DiGeorge deletion site.

They recapitulate natural selection and evolution: in complex gene networks, mutations or deletions of highly linked (hub) genes lead to embryonic lethality, while mutations of weakly linked genes account for biological variability and natural selection (Oikonomou and Cluzel, 2006).

The majority of cases of Lynch syndrome are attributed to heterozygous germline mutations in the DNA mismatch repair genes MLH1 and MSH2, and current methods for DNA sequencing and deletion analysis can successfully detect these mutations.

A new strategy for functional signaling studies of B ‐ cell lines by the CRISPR / Cas9 mediated deletion of BCR and B ‐ cell co ‐ receptor genes.

Researchers typically use viruses for two types of studies --(1) knock - in; introducing a protein - coding gene into cells to study its function, or (2) knockout / knockdown; studying gene function through deletion (potentially using CRISPR lentivirus knockout libraries) or reduction of gene expression, respectively.

It's possible that inherited regions of CNV with strong influence on gene expression are targeted for amplification / deletion by cancer cells, which might obscure their effect in an otherwise normal cell.

Future posts will include non-homologous end joining, using CRISPR for gene activation, creating deletions using CRISPR - Cas tools, validation, and more.

Many individual ASD patients had deletions or duplications of multiple genes within this network, but for those patients with just a single gene from the network changed, that single gene appeared to play an important role.

Using DECoN (which stands for Detection of Exon Copy Number variants), the researchers took advantage of the high density of sequencing data available in new gene panels to accurately detect deletions or duplications of exons.

The MMRRC is your one stop resource for unique and popular research related mouse models offering specific gene deletions, insertions, modifications and repressions, and phenotypes.

Using this technology, we screened 31 patient samples across an array containing a total of 162 exons for five disease genes and detected copy - number changes, ranging from whole - gene deletions and duplications to single - exon deletions and duplications, in 100 % of the cases.

Here, we describe the loss of a gene within the deletion that is responsible for the cardiomyophathy associated with monosomy 1p36, and confirm its role in non-syndromic left ventricular noncompaction cardiomyopathy (LVNC) and dilated cardiomyopathy (DCM).

Using our own data and publically available data from array comparative genomic hybridization (aCGH), we identified a minimal deletion for the cardiomyopathy associated with del1p36 that included only the terminal 14 exons of the transcription factor PRDM16 (PR domain containing 16), a gene that had previously been shown to direct brown fat determination and differentiation.

For each mouse line, Lexicon provided not only the mouse strain itself, but also detailed, objective data on the impact of the specific gene deletion on the mouse's phenotype, which includes appearance, health, fitness, behavior, ability to reproduce, and radiological and microscopic data.

Deletion of the TAM from a naive strain of E. coli results in a drastic time delay in folding of UshC, which can be observed for a protein from EPEC as well as for two introduced proteins from related organisms, Yersinia and Enterobacter We suggest that this models why the TAM machinery is essential for efficient folding of proteins acquired via lateral gene transfer.

Results: We confirmed the Gallus Gallus v5 consensus except for two insertions of 5 and 1 base pair within the chIFITM3 and B4GALNT4 genes, respectively, and a single base pair deletion within the B4GALNT4 gene.

For each mouse line, Deltagen provided the mouse strain, but also detailed, objective data on the impact of the specific gene deletion on the mouse's phenotype, which includes appearance, health, fitness, behavior, ability to reproduce, and radiological and microscopic data.

With our group, we address the question if deletion of the mammalian Indy gene (mIndy) also promotes longevity in mammals and we look for molecular mechanisms explaining the effects of mIndy on metabolism, aging, and life span.

It has examined how new genetic findings (duplication and deletion or changes in genes) influence the response to various drugs and whether this information can be used to choose the right drug for the right patient.

They also described the gene's size and genetic deletions associated with disease, including a very large deletion of the gene coding for dystrophin found in a patient with mild disease.

CAHDetx evaluates the CYP21 gene, detecting mutations and gene deletion / conversions that account for approximately 90 % to 95 % of all CAH cases.

We have identified a genetic deletion for a gene that functions by holding cardiac cells together.

Researchers at the University of Pennsylvania have developed a test to detect the deletion that occurs in the gene that codes for alpha - fucosidase.

Regardless of whether Mann deleted his own emails regarding AR4, Mann participated in the conspiracy to delete emails when he assured Jones that he would contact Gene Wahl about Jones request for deletion of emails regarding AR4.

Fowler et al. (2009) found that a variable number tandem repeat (VNTR) polymorphism in the gene encoding monoamine oxidase A (responsible for catabolism of serotonin and other catecholamine neurotransmitters), and an insertion / deletion polymorphism in the SLC6A4 promoter (5 - HTTLPR) were associated with what the authors term the «emotional dysfunction» aspect of psychopathy (a construct that corresponds with CU traits) in a sample of adolescents with attention deficit hyperactivity disorder (ADHD)[18].