Sentences with phrase «for gene duplication»

In addition, there is evidence for gene duplication, pseudogenes, and paralogs, although the extent of these is not clear (Kovach et al. 2010; Pavy et al. 2012).

Not exact matches

Women who convert more codeine to morphine have a duplication of the gene encoding for cytochrome P450 2D6.

In this cycle, new gene copies often arise by gene duplication, with the copies persisting or adapting into new roles within the genome for varying lengths of time, or dying off and being lost randomly.

The work of Marcet - Houben and Gabaldón revealed that, for yeast, hybridization was indeed behind the duplication of some genes.

And what we did is, in order to figure all this out, sort of trace the path of evolution, we did a whole bunch of sort of, swapping experiments, where we swappedGAL1 for GAL3and we swapped the ancestral protein type of protein in for GAL1or for GAL3, and we even swapped the GAL1and GAL3in for the ancestral protein, in another yeast that didn't have the duplication take place; and from this whole series of experiments, we really expected to find out pretty much how the proteins have changed; and the surprise was that most of [the] adaptive change that had taken place wasn't in the protein, it was in how the two genes were regulated.

For instance, his team found that around 2000 genes are expressed at levels higher than those of normal human tissues because of the duplications.

Researchers checked the genomes of 150 patients with schizophrenia and those of 268 healthy people, looking for large duplications and deletions of genetic material that disrupted the function of a gene.

When a gene duplication gave some water striders a novel leg part, it opened up a new world for them

The genomic data provides a strong evidence from DNA level to illustrate why Chinese alligator can hold its breath under water for long periods of time, such as the duplication of the bicarbonate - binding hemoglobin gene, positively selected energy metabolism, and others.

«In order for something to evolve, duplication of a gene is the most important event,» Hsu says.

Early investigations into the nature of genetic evolution proposed two potential mechanisms for the origin of new features: gene duplication and divergence, and regulatory changes in gene expression.

For several decades, much attention has been placed on gene duplication as a source of new gene functions.

Compared with the ancestral lineage, the East African cichlid genomes possess: an excess of gene duplications; alterations in regulatory, non-protein-coding elements in the genome; accelerated evolution of protein - coding elements, especially in genes for pigmentation; and other distinct features that affect gene expression, such as insertions of transposable elements and regulation by novel microRNAs.

Many individual ASD patients had deletions or duplications of multiple genes within this network, but for those patients with just a single gene from the network changed, that single gene appeared to play an important role.

Using DECoN (which stands for Detection of Exon Copy Number variants), the researchers took advantage of the high density of sequencing data available in new gene panels to accurately detect deletions or duplications of exons.

This is a unique scientific paradigm: the first publication determining the role of human - specific gene duplications during brain development came out of our laboratory recently (Charrier et al., 2012) and represents a milestone in our understanding of the genetic and neurobiological mechanisms underlying the emergence of human - specific traits of brain development, for example neoteny during synaptic maturation (Benavides - Piccione et al., 2002; Petanjek et al., 2011).

Using this technology, we screened 31 patient samples across an array containing a total of 162 exons for five disease genes and detected copy - number changes, ranging from whole - gene deletions and duplications to single - exon deletions and duplications, in 100 % of the cases.

To compensate for the duplication, genes are inactivated on one chromosome or the other in the early development of the embryo.

The gene variant for white colour in pigs differs from the gene variant found in wild boar, with at least five different mutations, four of which are duplications of DNA sequences.

It has examined how new genetic findings (duplication and deletion or changes in genes) influence the response to various drugs and whether this information can be used to choose the right drug for the right patient.