Sentences with phrase «for gene identification»

• Mouse whole genome scanning The unit offers microsatellite and SNP based Genome Scanning Services for gene identification projects, based on linkage analysis, offering coverage for a number of mouse strains (i.e. C57BL6, DBA2J, CBA, 129S6, 129P2), as well as bioinformatic analysis using suitable mouse genetic software.

The March of Dimes Prematurity Research Center — Ohio Collaborative, launched in 2013, is responsible for the gene identification component of the network of five Prematurity Research Centers nationwide established by the March of Dimes to identify the unknown causes of preterm birth.

Not exact matches

These genes are implicated in highly penetrant genetic disorders for which surgical or other interventions aimed at preventing or significantly reducing morbidity and mortality are available to pathogenic variant carriers.5 Identification of a pathogenic variant in one of these genes could be diagnostic of a medical condition with potential implications for an individual's medical management.

Last December, the same research team demonstrated blocking the expression of the gene that encodes apoC - III led to major relief of triglyceridemia in patients suffering a rare and extreme form of hypertriglyceridemia, which in turn opened the door for the identification of unexpected mechanisms that govern blood fat.

Identifying the gene defect enables the identification of those dogs used for breeding that carry the defect, which, in turn, makes it possible to effectively eradicate the disorder from the entire breed.

Much like the association between BRCA gene mutation and the risk for breast cancer in women changed the approach to treatment / prevention, the identification of the Kallikrein 6 gene region may change the course of prostate cancer care through a blood test developed by the Lunenfeld - Tanenbaum Research Institute.

«Now that we have narrowed down the hunting ground, these findings provide us with a focused direction for identification of the gene itself.»

The photo - clickable miRNAs are able to form functional complexes with target genes upon delivery into cells and target genes associated with the photo - clickable miRNAs could be tagged with molecular handle through photo - click reaction for pull - down and identification.

Over the longer term, the identification of the coffee tree genome sequence opens up new possibilities for varietal improvement, knowledge of the specific functions of the genes (in particular those specific to coffee trees), the possibility of transferring results to other species, and refining diagnostic tools for the function of the plant.

Teeth are crucial for fossil identification because they are both durable and closely regulated by genes.

«This knowledge will facilitate identification and isolation of additional resistance genes for improved control of Septoria,» adds Kanyuka.

As Finnish geneticist Leena Peltonen wrote in a recent review, «The enthusiasm regarding the use of population isolates for the identification of predisposing genes for common, polygenic diseases has turned to a silent drudgery.»

Just as the Human Genome Initiative in the 1990s sequenced human DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applications.

«The identification of these genes paves the way for the development of a test to identify individuals who are at risk of getting Fuchs dystrophy, and also for the development of drugs to slow disease progression or to potentially delay or prevent it from occurring,» said George A. McKie, D.V.M., PhD., director of the NEI's cornea research program.

It will also allow for easier identification of genes that contribute to the bacteria's spread from patient to patient, and more meaningful scientific experiments to understand the bug's resistance to antibiotics or identify new antimicrobial compounds that target specific genes necessary for maintaining these persistent infections.

Genetics play a strong role in risk for depression, but the identification of specific genes contributing to the disorder has eluded researchers.

Daniel Cosgrove, president of the American Society of Plant Physiologists, expects that the sequence data will also speed the identification of genes to improve agriculture and the use of plants as energy sources or for cleaning up the environment.

The first known identification of two genes responsible for hypoplastic left heart syndrome (HLHS), a severe congenital heart defect, has been reported by researchers at the University of Pittsburgh School of Medicine.

In particular, the comparison of gene sequences in large numbers of patients and controls will be a key step in strategies for disease gene identification.

The importance of this lies in proving the usefulness of the amelogenin gene as a standard for gender identification.

Collaborative research in Japan, under the guidance of the principle investigators from Fujita Health University and RIKEN, led to the identification of a novel risk gene (FADS1 and FADS2) for bipolar disorder via GWAS performed using samples collected in Japan (2,964 cases and 61,887 comparison subjects).

Nor does the identification of «genes for learning disabilities» help students to learn better.

Dr Todd said: «The identification of the DMSP synthesis genes in marine bacteria and phytoplankton allows us to evaluate for the first time which organisms produce DMSP in the environment.

The scientists» genomic search narrowed in on genes that code for the production of antigens, which serve as a source of identification to the immune system.

«Our systematic screen offers an important first step toward the comprehensive identification of all miRNAs and their potential targets that serve in gene networks important for normal learning and memory,» said Ron Davis, chair of TSRI's Department of Neuroscience who led the study.

In December, the Nobel Prize for Medicine and Physiology will be awarded for the identification of genes that control the biological clock.

Kidney research at the University of Virginia School of Medicine has unexpectedly led to a discovery about the formation of the heart, including the identification of a gene responsible for a deadly cardiac condition.

Back in the lab in Norman, Lewis and his colleagues used state - of - the - art gene sequencing methods that allowed them to get long segments of the gene that is used as the standard for classification and identification of microbes, because it differs in various bacteria.

Still, «this is the first clear identification» of a gene «with direct relevance for language ability,» says geneticist Svante Pääbo of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany.

Identification of these genes provides support for previously hypothesized mechanisms of high - altitude adaptation and illuminates the complexity of hypoxia - response pathways in humans.

But the identification of the mutation also brought new questions for the researchers that caused them to dig deeper into the gene.

On the other hand, the gene Trypsin - 7 appears to affect the recognition potential, thus enabling — at least in part — the identification of the host colonies required for a raid,» adds Feldmeyer in summary.

Dr George Vassiliou, joint project leader from the Sanger Institute and Consultant Haematologist at Cambridge University Hospitals NHS Trust, said: «This research has led to the identification of many potential gene targets for future AML therapy, which we are making available to other researchers to explore.

Conventional methods for identification of both RP mutations and novel RP genes involve the screening of DNA coding sequences.

Targeted gene therapies, however, had to wait for (1) the identification of the genes to target, (2) the cloning and / or sequencing of the relevant genes and in some cases, the specific disease - causing variant, (3) a full understanding of the normal gene function and regulation, and (4) the development of efficient ways to deliver genes to the relevant tissues at therapeutic levels.

For adenovirus genes that are spliced (e.g. E1A), the identification of a GT - AG intron start - stop signal was used to pinpoint the correct ORF.

Genome - scale metabolic models as platforms for identification of novel genes as antimicrobial drug targets — Bashir Sajo Mienda — Future Medicine

For their seminal contributions to concepts and methods of creating a genetic map in the human, and of positional cloning, leading to the identification of thousands of human disease genes and ushering in the era of human genetics.

My research interests include computational methods for analyzing tumor heterogeneity, driver gene identification in cancer, and detecting bias in biological network analyses.

The identification of genes that are synthetically lethal in β - catenin - activated cancer cells would provide new targets for therapeutic drug design.

Through its population - based approach and three main business units providing disease - gene and drug target identification, database services and informatics tools, deCODE is turning raw genomics data into products and services for the healthcare industry.

GOMiner — To provide additional statistical stringency to the identification of potential targets, we then analyzed the data sets generated by the SAM - RS analysis of the microarray data for hypoxia - associated coregulation of multiple, functionally related genes.

Regions and genes are functionally annotated to allow for rapid searching and visual identification of regions of interest with the option that user - supplied genomic phylogenies and metadata can be incorporated.

In the course of this work, he has pioneered several new approaches in the fruit fly that have had important implications for mammalian neurobiology, including: the demonstration that the fruit fly has a sleep - like behavior similar to that of mammals, studies of physiological and behavioral consequences of mutations in a neurotransmitter system affecting one of the brain's principal chemical signals, studies making highly localized genetic alterations in the nervous system to alter behavior, and molecular identification of genes causing naturally occurring variation in behavior.

Normally gene identification starts with what is called a case - control design, in which genetic variations are compared between patients with a condition and healthy individuals, to look for differences that may contribute to the disease.

The team's identification of a direct cooperation between these two cancer genes paves the way for targeted treatments - not only in ALL, but also in other leukemias where JAK3 / STAT5 could cooperate with HOXA9.

«If we can establish a link between abnormal forms of this gene and ADHD, it could provide us with a powerful new tool for precise diagnosis and early identification of children at risk, and a signpost toward designing better drug treatment,» said Ed Cook, associate professor of psychiatry and of pediatrics at the University of Chicago and lead author of the report.

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The identification of gene variants that delay fracture healing could lead to screening tests for patients with broken bones.

Her current research is focused on the identification of genes and molecular pathways for rare disorders and she is the Lead Investigator of the Genome Canada, CIHR funded «Finding of Rare Disease Genes in Canada» (FORGE Canada) and «Enhanced CARE for RARE Genetic Diseases in Canada» initiatgenes and molecular pathways for rare disorders and she is the Lead Investigator of the Genome Canada, CIHR funded «Finding of Rare Disease Genes in Canada» (FORGE Canada) and «Enhanced CARE for RARE Genetic Diseases in Canada» initiatGenes in Canada» (FORGE Canada) and «Enhanced CARE for RARE Genetic Diseases in Canada» initiatives.