Sentences with phrase «for gene rearrangements»

They also include a comprehensive bioinformatics package, enabling you to identify the DNA sequence, clonal prevalence, and V - J family identity for each gene rearrangement.

As a reagent manufacturer, we offer a comprehensive selection of gel, capillary, and next - generation sequencing PCR assays for gene rearrangement, chromosome translocation, and gene mutation detection as analyte specific reagents (United States), research use only, or CE - marked in vitro diagnostics to laboratories (outside of North America).

These assays, developed for use with specific Next Generation Sequencing (NGS) platforms, combine optimized, proprietary multiplex PCR master mixes with a software package that converts NGS output data to an easily interpretable form, enabling you to identify the DNA sequence, clonal prevalence, and V - J gene identity for each gene rearrangement.

Not exact matches

To that end, the US National Center for Biotechnology Information in Bethesda is developing a database, ClinVar, to integrate clinical and genetic data; others, such as DECIPHER, run by the Sanger Institute, handle genetic data such as chromosome rearrangements that can disrupt genes.

After enriching for CTCs, the researchers analyzed the samples for ALK rearrangements and for an increase in the number of copies of the ALK gene.

Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker - guided treatment is cost - effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer (NSCLC) setting in the United States.

Dorothy Romanus, lead author of the study, states «this analysis supports the value of multiplexed testing for EGFR and ALK gene rearrangements followed by molecularly - guided therapy in decisions surrounding coverage of related testing and targeted therapy.

Two types of immature B cells, namely fetal liver hybridomas and the leukemic cell line 70Z / 3, both of which have cytoplasmic mu chains but no light chains, were examined for DNA rearrangements of their light chain and heavy chain immunoglobulin genes.

The results suggest that, although the lack of light chain synthesis can be due to a lack of gene rearrangement, there may also be transcriptional regulation, which may also be important for the expression of light chain immunoglobulins in immature B cells.

The commercial tests were based on both Sanger sequencing and supplementary testing for large genomic rearrangements in both genes.

They then looked for DNA breaks associated with receptor gene rearrangement by using a version of the polymerase chain reaction that amplifies broken DNA.

How these self - promoting genes jump to these prime locations remains a mystery, but the researchers believe it may have to do with the DNA's three - dimensional structure in particular areas that allows for genetic rearrangement when the genome is being copied or when certain genes are active.

She found, for example, that by using a technique called the polymerase chain reaction to amplify genes, she could detect mutations or rearrangements in cancer - specific genes in irradiated tissue that had turned cancerous.

Kin Ritchie, Ralph Brinster, and Ursula Storb show that an IgL transgene inhibits rearrangement of endogenous IgL genes, providing the first clue for the mechanism of allelic exclusion of Ig genes.

Studies on horizontal gene transfer and enzymemediated DNA rearrangements lead him to postulate a theory of molecular evolution according to which nature cares actively for the promotion of biological evolution by using products of specific evolution genes as well as several intrinsic non-genetic elements.

Duration of Symptoms Does Not Correlate with Results of T - cell Gene Rearrangement Studies in Patients Evaluated for Cutaneous T - Cell Lymphoma.

The LymphoTrack ® Dx TRB Assay for the Illumina MiSeq ® is an in vitro diagnostic product intended for next - generation sequencing (NGS) based determination of the frequency distribution of TRB gene rearrangements in patients suspected with having lymphoproliferative disease.

Our NGS kits are used to detect clonal gene rearrangements, somatic hypermutations and for the study of MRD.

For example, during T - cell development genes encoding the TRB molecules are assembled from multiple polymorphic gene segments that undergo rearrangements and selection, generating Vb — Db — Jb combinations that are unique in both length and sequence.

Another effort is to identify genes involved in human development, known as DGAP (Developmental Genome Anatomy Project), which uses naturally occurring human chromosomal rearrangements in association with major congenital anomalies as the biological reagents for gene discovery.

-- We have shown that the genetic change causing fibromelanosis is a complex rearrangement that leads to increased expression of Endothelin 3, a gene which is known for promoting the growth of pigment cells, explains Ben Dorshorst the post-doctoral researcher responsible for the work.

We have been searching for a mechanism that can explain the genetic cause of majority of BWS and that can provide better understanding of intragenic mutation of p57KIP2 and disruption of KvLQT1 gene by balanced germline chromosomal rearrangements.

A number of Invivoscribe LymphoTrack Assays, formatted for use on both the Illumina MiSeq ® and Thermo Fisher Ion PGM ™ platforms, were designed to detect somatic gene rearrangements within the antigen receptor loci.