Sentences with phrase «for gene signatures»

The Duke team has previously explored blood tests to examine a patient's RNA for gene signatures to distinguish bacterial and viral infections in the upper respiratory tract and is working with a private company to develop potential diagnostics.

Other biomarkers and genetic signatures are being used in an effort to predict the aggressiveness of an individual patient's prostate cancer, «but the current information doesn't make it possible for their gene signature to be an actual target for precision medicine targeted therapy,» Ellis explained.

Not exact matches

The researchers constructed a signature for type 2 diabetes based on 50 genes, then used publically available expression datasets to screen 3,852 compounds for drugs that potentially reverse disease.

Surveillance organizations like the U.S. and world antidoping agencies «will look for those signatures and patterns that can be tied, with confidence, to the existence of a foreign gene,» Friedmann says.

Although a bad outcome was possible without the gene expression pattern, patients with the genetic signature were found to survive for less time than those who didn't have it, they wrote in the 9 December online edition of Nature Genetics.

Rudich says that the study enabled the researchers to identify a «signature» for each source of bacteria based on the prevalence of antibiotic resistant genes, which revealed whether the genes were local or imported from distant deserts.

«We're generating so much sequence data right now, from so many species, that it's relatively straightforward to look for signatures of selection in genes and to find good candidates for adaptations,» Montooth said.

Their findings indicate that intuition and signatures of selection in gene sequence may not be enough for scientists to conclusively solve the puzzles of molecular evolution.

Surveillance organizations like the U.S. and world agencies «will look for those signatures and patterns that can be tied, with confidence, to the existence of a foreign gene,» Friedmann says.

Therefore, we sequenced the whole exomes of 98 HCCs from two hospitals in Taiwan and found that 78 % showed the distinctive mutational signature of AA exposure, accounting for most of the nonsilent mutations in known cancer driver genes.

The eight - gene signature was also compatible for people with lower grade glioma.

An eight - gene - based risk signature was established for risk stratification.

In a March 2009 study published in Genes and Immunity, researchers at the National Center for Computational Toxicology compared the genetic signatures of 16 people who experienced smallpox vaccine side effects, including fever, rashes and enlarged lymph nodes, to 45 people who did not.

One defends that these molecular signatures suggest a common evolutionary origin of skin appendages, whereas the other proposes that the same genes are re-used for developing different skin appendages.

Moreover, certain signature Mimi genes, such as those that code for the production of the soccer - ball shape of its capsid (an outer protein coat common to all viruses), have been conserved in viruses that infect organisms from all three of the domains, particularly in eukaryotes.

The initial hint that KLF4 regulates mitochondrial biology came from genome - wide studies that revealed a strong signature for KLF4's control of mitochondrial genes.

Our next step is to start exploring our dataset in the search of such patterns of selection, for new signatures of gene flow among chimpanzee subspecies.»

But researchers are beginning to uncover a biological explanation for the problem: they have found a gene that may contribute to its development as well as a pathological signature of the disorder in the brain.

«If we knock out, one by one, a wide range of genes of known function, and analyze proteins, metabolites and lipids, using the technology that Josh's group has developed, the data provide a «signature» for what each protein is doing.

For example, the researchers were able to identify previously unknown gene expression differences between the neural stem cells that give rise to the brain's deep structures versus its neocortical surface, and to show that molecular signatures of different neural cell types arise much earlier in brain development than previously realized.

Researchers from UCL (University College London) identified an epigenetic signature in the blood of women predisposed for breast cancer owing to an inherited genetic mutation of the BRCA1 gene.

So the shark - specific signature of adaptation found in the Bag1 gene may indicate an alternative, or modified role for this important gene — one that could alter its tendency to inhibit programmed cell death in sharks.

The signature gene could provide a more accurate diagnostic biomarker for cancer staging.

About the Prosigna ® Breast Cancer Prognostic Gene Signature Assay and nCounter ® Dx Analysis System The Prosigna Assay provides a risk category and numerical score for assessment of the risk of distant recurrence of disease at 10 years in postmenopausal women with node - negative (Stage I or II) or node - positive (Stage II), hormone receptor - positive (HR +) breast cancer.

A team led by Pablo Tamayo and Jill Mesirov of the Broad Institute and University of California, San Diego, and Broad bioinformatician Arthur Liberzon, has generated «hallmark» gene sets from the Molecular Signatures Database (MSigDB), one of the most comprehensive and widely used databases for gene set enrichment analysis.

(b) Network constructed as in a using genes from the salmon, tan, blue and black modules all enriched for genes in the meditation signature.

A transcriptome research of its organs revealed its gene signature is highly evolved and adapted for extreme longevity (slow metabolism, improved insulin gene signaling and glucose homeostasis, thus reduced blood glucose, improved cancer genes, improved endothelial function by eNOS (endothelial Nitric Oxide Synthase) meaning improved vascular coronary blood flow, improved microvasculature arterial and heart endothelium function) but more importantly, to answer your question, some whales display low blood glucose hypoglycemia, this affects the quantity and period of proteins / DNA / cell exposure to glucose glycation, glycosylation and glycoxydation reactions.

On the other hand, two Italian wolves with an unusual, black coat colour did not show any genetic signatures of hybridisation, except for carrying a dog - derived variant of a gene linked to dark colouration.

Whole - genome sequencing of the blue whale and other rorquals finds signatures for introgressive gene flow

This signature of recent positive selection had previously been observed for coding variants in melanogenesis pathway genes.

We found that a gene signature consisting of 273 genes important for breast cancer bone metastasis showed decreased expression in ABL1 / ABL2 knockdown cells (Fig. 6B)(38).

In the current study, published online in eLife, Rohban, Carpenter, and their colleagues overexpressed 220 genes one - by - one in cultured cells, dyed the cells, and searched for signatures associated with each gene.

The team found that they could identify such signatures for half of the genes studied.

The reprogramming strategy described here revealed a potential transcriptional signature for human iPSCs yet retaining the gene expression of donor cells in human reprogrammed cells free of viral and transgene interference.

Recently, we have successfully applied our integrated approach to identify a 10 - gene prognostic signature for early stage lung cancer (25).

To characterize the resistome in detail we searched the metagenomes for signatures of known antibiotic resistance genes.

With the development of novel genomics technologies, such as Next - Generation Sequencing, numerous new mutations and gene expression signatures have been identified, allowing us to better understand the molecular heterogeneity of hematologic diseases and to better stratify and assess risk for cancer patients.

Patients whose tumors had a gene - expression signature associated with poor survival lived for a period that was 23 percent shorter than patients whose tumors did not have such a signature.

Intriguingly, our hBCSGs are mostly unrelated to cell cycle / mitosis genes and are distinct from the prognostic signatures currently used for stratifying BC patients.

LUMC offers an extended multiplex transcriptome profiling assay (dcRT - MLPA) for monitoring innate, adaptive and inflammatory immune - response signalling gene signatures, which can be used to evaluate and improve immunisation strategies.

For example, a recent study developed a cell proliferation signature that consists of the top 1 % genes whose expression is most positively correlated with that of proliferating cell nuclear antigen (PCNA).

In fact, MELK and other proliferation - related genes are major components of multi-gene signature for predicting disease outcome.

To this end, my laboratory will screen blood from pediatric samples to look for evidence of asthmatic gene expression signatures (as originally defined in adults).

SMILF Picked up to series; 10 episodes STUDIO: ABC Signature Studios / Showtime TEAM: Frankie Shaw (w, d, p), Lee Eisenberg (ep), Gene Stupnitsky (ep), Michael London (ep) LOGLINE: A raw look at a single twentysomething in Boston whose desires for relationships, sex and a career collide with the realities of being a young single mother.

Although elevated dN / dS is a common metric for evidence of selection when comparing single genes, dN / dS values are much lower for signatures of selection across the entire mitogenome [33].