Sentences with phrase «for gene silencing»

RNA interference (RNAi)-- a revolutionary technique for gene silencing.

«The Chp1 - Tas3 core is a multifunctional platform critical for gene silencing by RITS,» appears in Nature Structural and Molecular Biology on November 13.

This work is complemented by a second study that presents snapshots of PRC2 binding to the histone proteins that it modifies as a signal for gene silencing.

A protein that is responsible for gene silencing (heterochromatin protein 1?)

«These particles, microRNA based SNAs, could also potentially be used for gene silencing in other cancers and diseases of genetic origin.»

Not exact matches

But his statement is so eloquent that I'll silence my defensive gene for now.

Researchers still have much to learn about the imprinting process and the genes involved, Zhang says, but the discovery of a second mechanism for silencing one copy of these genes underscores imprinting's importance.

For a very small number of genes, though, people inherit only one working copy; the other copy is turned off, forever silenced.

However, for a few genes, only one allele is expressed, while the other one is silenced.

Ian Baldwin of the Max Planck Institute for Chemical Ecology in Jena, Germany, and colleagues genetically modified petunia plants to silence genes responsible for producing specific scent molecules.

«Our approach to gene silencing has not been demonstrated before in such a powerful way for the treatment of brain cancers,» Stegh said.

If the silencing occurred in a gene responsible for suppressing tumor formation, the result would appear the same as genetic mutations that predispose people to cancer.

For instance, alterations to these chemical switches can change the architecture of the heterochromatin, causing genes to be expressed or silenced.

Study shows memories formed by the same gene - silencing tool used in embryonic development; a finding could set the stage for new therapies for schizophrenia

The gene is silenced because it is on the part of their chromosome they inherited from their mother, and for mysterious reasons our cells use the father's copy of this gene.

By silencing the genes that account for the three major allergy - causing proteins in peanuts, researchers at Alabama A&M University in Normal hope to grow safer peanuts.

RNA interference (RNAi), a technique for silencing genes that shows potential for treating diseases, has been like a hot baseball prospect who hasn't proven he can play in the big leagues.

Not only is RNAi used to regulate gene expression within an organism, it also can combat viral infection by silencing the activity of viral genes required for the pathogen's replication.

The researchers treated 63 cancer cell lines (26 breast, 14 colorectal and 23 ovarian) with low - dose 5 - azacitidine (AZA), an FDA - approved drug for myelodysplastic syndrome, that reverses epigenetic changes by stripping off the methyl group that silences the gene.

Fathers could also silence brain genes for their own evolutionary benefit.

They propose that normal tissue becomes primed for cancer when oncogenes are activated and tumor suppressor genes are silenced or lost, but that cancer develops only when a cell in the tissue reverts to a more primitive, embryonic state and starts dividing.

To kill an insect, the RNAs must silence a gene essential for life, and species often share genes of such crucial importance, making it difficult to target one insect over another.

Typically, mutations that silence genes are bad for your health.

«Silencing is golden: Scientists image molecules vital for gene regulation.»

They managed to remove the specific enzyme for triglycerides by silencing its coding gene, but only at the heart of the reward mechanism.

This cascade of activity enables PRC2 to spread this modification over the entire neighboring gene loci, thereby marking it for silencing.

In another paper in the same issue, a team led by molecular biologist Ronald Plasterk, now at the Hubrecht Laboratory in Utrecht, the Netherlands, reports an intriguing twist: The same genes appear to be responsible for both RNAi and another gene - silencing mechanism known as cosuppression, in which adding extra copies of a gene cause both the new and the existing copies of that gene to be shut down.

Early in development, though, the silencing tape is ripped away, leaving genes unmarked and ready for action.

ASCB President Don Cleveland of the University of California, San Diego, said his team just published an animal study on a gene silencing therapy for treating a form of Lou Gehrig's disease that they now hope to move to clinical studies.

For example, information stored in the chromatin silence liver specific genes in heart cells and vice versa.

The researchers at Bonn University and their colleagues from the Federal Institute of Drugs and Medical Devices (BfArM) and from the University of Regensburg worked with so - called transgenic and knockout mice in whom the gene for micro-RNA 155 was either increased or silenced.

Now researchers have developed a new method for silencing specific genes in mammalian cells.

«If cells with a certain gene silenced disappear, for example, it means that gene is essential for proliferation.»

Day and colleagues propose a model where ecRNAs directly interact with the catalytic domain of DNA methyltransferases to block the ability of the methyltransferases to target and silence the overlapping gene for each specific ecRNA.

Researchers have collected information on which genes are activated or silenced in certain diseases and by certain drugs for many years.

The genes responsible for the enzymes that brown the flesh are silenced.

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).

For instance, some of these phage elements can activate or silence bacterial genes by moving into or out of the chromosome.

«Experimental therapy for Prader - Willi syndrome shows promise in mice: Strategy activates silenced genes.»

First author Dr Reza Haqshenas said the researchers then used gene silencing technology to determine whether the genes» cell factors identified using the antibody microarray were indeed important for HCV replication and therefore potential targets for anti-HCV compounds.

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo.

It has also been suggested that methylation is not the initial event in triggering gene silencing in cancer; rather, the methylation of the promoter CpG islands is a consequence of prior gene inactivation, and it is a mechanism for locking the chromatin in a repressed state (5, 13, 37).

If what you've read here about zinc finger technology reminds you of «gene silencing» or «huntingtin - lowering» methods for treating Huntington's disease, give yourself a gold star.

Toni Bedalov investigates drug candidates for anticancer therapy in breast - cancer malignancies, illuminates the molecular process of gene silencing

In female mammals, one of the two X chromosomes is transcriptionally silenced during early development to compensate for the double «dose» of X-linked gene products in females -LSB-...]

In addition, A-to-I RNA editing is involved in control of the expression and function of microRNA (miRNA), which is a small RNA essential for the RNAi mediated gene silencing mechanism.

The third PDR approach and the one that we intend using not only for MSV resistance but also for other viruses such as MRDV, is based on something called RNA - mediated gene silencing.

A novel disrupter of telomere silencing 1 - like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)- activated gene expression.

Scholar - in - Training Awards in the amount of $ 1,000 for her submitted abstract entitled, «Activator protein 2 alpha (AP2α)- targeted methylation and silencing of relevant genes in head and neck squamous cell carcinoma (HNSCC) pathogenesis» to be presented at platform session at the 100th Annual Meeting of the American Association for Cancer Research, Denver, CO..

ALS can be caused by a mutation in a protein called SOD1, and the antisense drug effectively silences the gene that codes for this mutant protein — found in the cells of patients with inherited forms of ALS.