The Nagy ES cell collection is a panel of basic ES cells that can be used
for gene targeting.
• ES cell line purity verification In addition to mouse strain purity verification, the facility provides genetic screening of ES cell lines used
for gene targeting experiments.
Bengt Nordéns contribution to form a strong research school in Gothenburg has been successful: as many as 12 out of his about 50 former PhD students and postdocs have become professors, abroad or at other Swedish universities, and three have returned to contribute a forceful environment with their own profiles within the Department: Prof Bo Albinsson (femtosecond spectroscopy and fundamentals of electron transfer), Prof Per Lincoln (new transition - metal - based DNA ligands and statistical mechanics
for gene targeting), Prof Björn Åkerman (fundamentals and applications of DNA physical chemistry).
Not exact matches
Gene therapy, for example, frequently involves using a virus to deliver a gene to the cells that scientists are target
Gene therapy,
for example, frequently involves using a virus to deliver a
gene to the cells that scientists are target
gene to the cells that scientists are
targeting.
The technology's possibilities are staggering — in theory, allowing medical scientists to do everything from cure genetic disorders like sickle cell disease to identify
gene targets for combating HIV.
I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions
for preventing infections in some common surgeries, tackling resistance in
targeted antibody drugs, improving
gene vectors
for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.
In our tests, the
Gene Knockout Kit gave us greater than 80 percent knock - out rates
for seven
targets,» shares Shondra Miller, Ph.D., Director, Center
for Advanced Genome Engineering at St. Jude Children's Research Hospital, on Synthego's web site.
«Those carrying the
target gene variant slept, on average,
for five hours, which was one hour shorter than their twins without the
gene.
*** The search
for a «gay
gene» may be off -
target, new research finds.
[The search
for a «gay
gene» may be off -
target, new research finds.
During the dialogue, Dr
Gene Nisperos of the Health Alliance
for Democracy raised his concern as the
target of Golden Rice are members of the vulnerable population such as preschool children and lactating mothers.
That could eventually lead to new drugs that selectively
target the
gene, which McCarthy says, «could be a strategy
for treating mood or sleep disorders.»
«Until recently we have been looking
for individual
genes associated with diseases, which drug companies then
target with treatments.
The researchers also described the full
gene repertoires
for known drug
target families.
Because the
genes that are massively amplified in the neochromosomes are essential
for the cell's survival, drugs that turn those off are an obvious
target for research.
«The extensive overlap in risk
genes for autism and cancer, many of which are chromatin remodeling factors, supports the idea of repurposing epigenetic drugs used in cancer treatment as
targeted treatments
for autism,» said Yan.
In SIF - seq, hundreds or thousands of DNA fragments to be tested
for enhancer activity are coupled to a reporter
gene and
targeted into a single, reproducible site in embryonic cell genomes.
The study, published online today in Science Translational Medicine, further points to a master switch
for these
gene sets as a potential
target of future therapies.
In particular, he has focused on
targeting the
gene coding
for flagellin protein b, or flaB, which has proved to be quite distinct from one genospecies to the next.
The Bill and Melinda Gates Foundation sees so much promise in
gene drive technology that it plans to double spending on its
Target Malaria initiative, which aims to create systems
for driving
genes in two species of malaria mosquitoes, to $ 70 million.
Knowing what the master
genes are could give scientists
targets for new pharmaceuticals to treat brain diseases.
Not surprisingly, MacDougald expects that a
gene -
targeted treatment
for our tubbiness is a long way off.
Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs
for normal body cells by connecting them according to which
genes they
target and the function of those
genes, in a way similar to analyses of human social networks.
If so, the master
genes would be even more promising as
targets for new treatments.
The finding suggests that other AAVs used
for a
gene therapy
targeting the brain or spinal cord might be improved by having the same or a similar set of amino acids.
Yang said the study not only indicated which
genes are affected by traumatic brain injury and linked to serious disease, but also might point to the
genes that govern metabolism, cell communication and inflammation — which might make them the best
targets for new treatments
for brain disorders.
Earlier MD Anderson investigations demonstrated exosomes as a factor in detecting pancreatic cancer, but these latest findings reveal genetically altered exosomes as a potentially novel approach
for direct and specific
targeting of mutated KRAS, the cancer
gene commonly linked to pancreatic cancer.
Parkinson contends that
targeted gene replacement produces cells having specific genetic alterations far more effectively than the traditional technique
for making transgenic animals, which entails injecting DNA into cell nuclei.
«By greatly narrowing the specific
genes involved in social disorders, our findings will help uncover
targets for treatment and provide measures by which these and other treatments are successful in alleviating the desperation of autism, anxiety and other disorders,» says Korenberg.
«
Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research found many
targeted therapies
for prostate cancer may not be effective against tumors in African - American men.»
«The number of protein functions that are currently
targeted by drugs is incredibly small compared to the total number of protein interactions that could be
targeted for therapeutic benefit,» says Geoffrey Wahl, a professor in Salk's
Gene Expression Laboratory.
For comparison, dsRNAs
targeting two different
genes were tested.
Their «kamikaze» CRISPR system not only disables the
target gene, it also disables the
gene for the cutting protein after a short delay.
Dwarki and Jaime Escobedo improved the AAV's ability to insert
genes into chromosomes by adding a
gene promoter region from cytomegalovirus, known to be active in the
target for their
gene therapy, muscle cells.
The researchers are now investigating the effects of these
genes» mutations as possible
targets for new therapeutic treatments.
«The trial is important
for gene research and may be a proof of principle that
targeting the most common mutation in cystic fibrosis is an effective approach
for treatment of most patients,» Gentzsch said.
It is typically less expensive to get preselected information about the 20,000 or so
genes that make up a person's exome — the section of the genome that provides instructions
for making proteins — than to perform a more precision - oriented test that
targets a single
gene.
If cells were infected with an influenza A mutant lacking NS1, they proceeded to produce large number of the molecular complexes required
for RNAi, which include a protein called Argonaute that slices through the
target gene.
Bach2, an important
gene for inducing memory B cells, may become an important
target in vaccine strategies.
The former
target, say, using
gene editing techniques to inactivate HIV receptors and achieve resistance of blood cells to the virus (which Sangamo BioSciences is working on in clincial trials) is different than helping parents who both carry
genes for Huntington's Disease to have a child that is free of the disease (a change to the genome that would be passed on to future generations and would likely not be very commonly needed).
Unlike whole - genome sequencing, this assay
targets a select set of
genes or regions with known associations with lymphoid cancer, allowing
for more rapid detection of a variety of mutations.
Studying how the knockout mutations affect those traits and health could point to
genes that are potentially safe and effective
targets for
They identified previously unknown recurrent loss - of - function mutations that
target genes regulating epigenetic pathways — ones that act on how tightly or loosely chromosomes are wound and thus accessible
for genes to be expressed.
For this study, Dr. Lou and his colleagues focused on triple - negative breast cancer, which is difficult to treat, because it does not exhibit receptors for estrogen, progesterone or the HER - 2 / neu gene, which are targets for many current breast cancer treatmen
For this study, Dr. Lou and his colleagues focused on triple - negative breast cancer, which is difficult to treat, because it does not exhibit receptors
for estrogen, progesterone or the HER - 2 / neu gene, which are targets for many current breast cancer treatmen
for estrogen, progesterone or the HER - 2 / neu
gene, which are
targets for many current breast cancer treatmen
for many current breast cancer treatments.
«The
genes which these miRNAs regulate also had increased levels, indicating that these
gene expression, indicating that these
gene products were likely
targeted for storage and
for possible future use within the brain cell, rather than
for destruction.
«PPM1D is itself a
target for drug development, because the
gene mutation causes cells to avoid death and proliferate,» Yan said.
The photo - clickable miRNAs are able to form functional complexes with
target genes upon delivery into cells and
target genes associated with the photo - clickable miRNAs could be tagged with molecular handle through photo - click reaction
for pull - down and identification.
The authors conclude that these
genes may represent new therapeutic
targets for HD.
The same process has been studied as a potential genetic therapy
for more than a decade, because you can
target any disease
gene with matching dsRNA.
«Plants with one type of glyphosate - resistance mechanism make multiple copies of the
target site
for glyphosate, a
gene called EPSPS.