Sentences with phrase «for gene transfer»

Physical Methods for Gene Transfer: Improving the Kinetics of Gene Delivery into Cells.

24 Newman C, Bettinger T. Gene Therapy Progress and Prospects: Ultrasound for Gene Transfer.

«Viruses for gene transfer to the lung could be engineered to contain JSRV envelope proteins, allowing them to specifically target lung cells.»

These cells are easily accessible (therefore, they are the first ones used in the clinic), seemingly well suited for gene transfer, and used in practice with new genes to correct two types of severe combined immunodeficiency (which are briefly described in the book).

In a new study published in the journal Scientific Reports, UFZ researchers have been able to demonstrate that these so - called fungal hyphae also form a hot spot for gene transfer between bacteria.

Intrigued by the ability of certain polymers to mop up DNA and RNA for gene transfer, Sullenger and colleagues tested the idea that these chemical compounds might also be effective targeting such nucleic acids as they arise in cell death.

Not exact matches

The OAR proposal uses a variation of therapeutic cloning called altered nuclear transfer (ANT) in which the nucleus of a donor cell (a skin cell, for example), containing the 30,000 genes of the genetic code, is altered in such a way that it produces an epigenetic factor, a protein called nanog.

During my time, more tools became available for plant breeders to transfer genes of interest and improve selection efficiency.

The scientists spent close to a decade tackling the difficult techniques required to transfer the genes and another to meet the stringent safety requirements for genetically modified organisms (GMO).

And Baross's lab work shows that the mid-Atlantic biofilms have an astonishing capacity for transferring genes.

Such embryos were transferred into female goats, which produced offspring that were then tested for the presence of the newly integrated gene.

Barroso spent his first year at GSK's Biopharmaceuticals Centre of Excellence for Drug Discovery near London looking at the use of adenoviruses in gene - transfer therapy.

«This regenerative technology, termed AAV gene transfer, provided long - lasting benefit to the entire musculature of affected dogs that would have otherwise perished, extending a healthy lifespan for more than 4 years,» said Dr. Martin Childers, senior author of the Muscle & Nerve study and a UW Medicine researcher in Seattle.

To boost production of the enzyme in animals, U.C. Davis scientists have transferred the human gene for the enzyme into dairy goats.

Issued last March to researchers at a little - known cotton seed company called Delta & Pine Land (D&PL) and the U.S. Department of Agriculture, the patent covers a technique for transferring three genes along with their genetic on switches into the seeds of genetically improved plants.

For the dozens of labs at work on the problem, coming up with useful genes, known as transgenes, is not the hard part — it's how to transfer enough copies of the transgenes into free - ranging populations.

By following the DNA - transfer, scientists for the very first time showed an unknown mechanism called carry back in which pathogens were able to snatch genes from far - related bacteria via the carry back mechanism.

Over many years, the NTNU University Museum has been studying what such an extreme gene transfer system means for the global propagation of these plants.

In agriculture, for example, researchers transfer genes from other organisms into crops to get certain characteristics.

Over the longer term, the identification of the coffee tree genome sequence opens up new possibilities for varietal improvement, knowledge of the specific functions of the genes (in particular those specific to coffee trees), the possibility of transferring results to other species, and refining diagnostic tools for the function of the plant.

Dr. Kirk Manogue, vice president of technology transfer at The Feinstein Institute for Medical Research in Manhasset, N.Y., said that there have been some safeguards built in to allow research on patented genes to continue without infringement on patent rights.

This group is well known for its design of retroviral vectors for efficient gene transfer and it seemed like a good idea for me to go there for a year and exchange knowledge and expertise.

Research areas include species for comparative research; phenotypic characterization; fitness, genome stability and lateral gene transfer; control of organismal traits; monitoring and surveillance; modeling and standardization of methods and data.

It is perhaps thus likely that that these damaged genes coding for psychiatric diseases are overrepresented in women with fertility problems, and, if transferred to their offspring, this may at least partly explain the increased risk of psychiatric diseases.»

Hilbert recommends to test therapeutic phages for their ability to transfer resistance genes.

During that time, he took a six - month sabbatical at the Center for Molecular Orthopaedics, Harvard Medical School / Brigham and Women's Hospital, in Boston to learn viral gene transfer techniques.

RNA serves as the template for translation of genes into proteins, transferring amino acids to the ribosome to form proteins, and also translating the transcript into proteins.

Transfer these genes into crop plants, for instance, and you are a step closer to producing insecticidal crops — «no - spray» cotton, potato and corn fit for Utopian farms of the 21st century.

Wick continues: «Our study shows that fungal hyphae not only provide soil bacteria with an excellent infrastructure, but also a potential hot spot for bacterial horizontal gene transfer.

The team's next goal was to transfer the genes for making gas vesicles from the water - dwelling bacteria into a different type of bacteria — Escherichia coli, which is commonly used in microbial therapeutics, such as probiotics.

Although in rare cases mitochondrial genes may be transferred to the nucleus of a cell, she said the IU team found no evidence to suggest this is the case in V. scurruloideum, and that further investigation will be required to reveal the exact mechanism through which the species compensates for its missing genes.

«Gene transfer on the fungal highway: Researchers show how fungi can improve the genetic makeup of bacteria and their potential for the breakdown of harmful substances.»

PARTICLE acts in three different ways to prevent expression of the MAT2A gene: 1) by winding around the MAT2A gene to create a DNA: RNA triple helix structure locking down the MAT2A gene promoter, 2) by binding the messenger RNA product of the MAT2A gene and preventing it being used for MAT2A protein synthesis and 3) transferring MAT2A messenger RNA into intracellular vesicles that are subsequently ejected from the cell.

By transferring only the genes necessary for disease resistance, Gray says the technique may leave the vine's other traits intact.

«This is the strongest evidence to date for lateral gene transfer,» says molecular evolutionist Ford Doolittle of the Canadian Institute for Advanced Research in Halifax, Nova Scotia.

But it stopped short of recommending a protocol - by - protocol approval process, something that the Recombinant DNA Advisory Committee implements for human gene transfer research.

Joshua Lederberg who recently passed away discovered this — and like many other people who studied E. coli — got the Nobel Prize for his work and this was a huge help, because you could now transfer genes from one E. coli to another and start to figure out what those genes actually did.

But gene transfer between kingdoms — from animal to bacteria for example, or vice versa, has been much harder to document.

The researchers found that many of the genes the phages carry and transfer are beneficial to the bacteria; some may help them repair cell walls, for example.

By transferring the gene for melanopsin into human embryonic kidney cells, synthetic biologist Martin Fussenegger of the Swiss Federal Institute of Technology in Zurich and colleagues made these cells light - sensitive as well.

Beyond the interest these lateral gene transfers evoke in evolutionary biology, these results highlight the risk gene transfers could cause, in case GM - parasitoid wasps are produced, as genes artificially introduced into wasp species used for biological control could be transferred into the genomes of the targeted pests.

Bengt Nordéns contribution to form a strong research school in Gothenburg has been successful: as many as 12 out of his about 50 former PhD students and postdocs have become professors, abroad or at other Swedish universities, and three have returned to contribute a forceful environment with their own profiles within the Department: Prof Bo Albinsson (femtosecond spectroscopy and fundamentals of electron transfer), Prof Per Lincoln (new transition - metal - based DNA ligands and statistical mechanics for gene targeting), Prof Björn Åkerman (fundamentals and applications of DNA physical chemistry).

However, like most gene transfer approaches a major concern with ZFN technology is the potential for oncogenesis due to off - target effects.

She identified that specific killing of myeloid cells represents an additional mechanism of suppression mediated by Tr1 cells, and she contributed to the definition of a new protocol for Tr1 cell induction using IL - 10 gene transfer and in the discovery of the biomarkers of Tr1 cells.

Genetic engineers directly transferred the gene for the toxic protein into crops to give them built - in resistance.

Antibody gene transfer for HIV immunoprophylaxis.

Since then he has continued to investigate new strategies to overcome the major hurdles to safe and effective gene transfer, translate then into new therapeutic strategies for genetic disease and cancer, and allowed new insights into hematopoietic stem cell function, induction of immunological tolerance and tumor angiogenesis.

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The scientists spent close to a decade tackling the difficult techniques required to transfer the genes and another to meet the stringent safety requirements for genetically modified organisms (GMO).

Using a novel technique to genetically modify T cells for adoptive transfer, Carl June, Michael Kalos, David Porter, Bruce Levine, and colleagues at the University of Pennsylvania School of Medicine achieve clinical responses in patients with chronic lymphocytic leukemia, including two complete, durable (one year) clinical responses, accompanied by in vivo expansion and long - term functional persistence of gene - modified cells.