Sentences with phrase «for genetic association studies»

If this is true, then there are important implications for genetic association studies, which often rely on surveys of common genetic variation in the human genome.

Not exact matches

The Immunochip for fine - mapping is an important tool for conducting genome - wide association studies of the genetic components of disease.

The results show that distinct genetic profiles underlie specific memory processes: The study reports, for example, associations between a transporter protein set and the process of learning as well as between a cell adhesion set and the process of memory storage.

«Genetic association with aggressive prostate cancer discovered: Study showed a threefold increase in the risk of aggressive prostate cancer for men with the genetic mutation..Genetic association with aggressive prostate cancer discovered: Study showed a threefold increase in the risk of aggressive prostate cancer for men with the genetic mutation..genetic mutation..»

Results of each statistical test should be reported in full with the value of the test statistic and p - value, and not simply reported as significant or non-significant; more than two significant digits on p - values are usually not needed except in situations of extreme multiple testing such as in genetic association studies where stringent corrections for multiple testing might be used.

The research team's hunt for such age - related genetic associations involved studying more than 8 million single nucleotide polymorphisms — changes of one nucleotide for another at a particular spot in the DNA — in 2,693 individuals.

«Our approach is likely to «revive» genome - wide association studies as a strategy to identify genetic risk factors and to develop novel treatment options for a wide range of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»

Clinical features of major depressive disorder (MDD) may help identify specific subgroups of depressed patients based on associations with genetic risk for major psychiatric disorders, reports a study in Biological Psychiatry.

In 2013, a genome - wide association study of AD in more than 5,500 African Americans identified two genetic risk factors for AD.

The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2016) showed for the first time an association between a specific genetic pathway and the development of mouth ulcers in patients with Systemic Lupus Erythematosus (SLE).

«Future studies on maternal smoking and other environmental, genetic, and epigenetic factors, as well as animal models, should allow identification of the biological mechanisms responsible for these associations.

«No link found between subcortical brain volumes, genetic risk for schizophrenia: Proof - of - concept study provides roadmap for future research into possible associations between brain volume measures, known genetic risk factors.»

Biologists typically look for genetic connections by using genome - wide association studies, which statistically associate genetic markers with disease.

Scientists for years have looked for the biological roots of the problem using tools such as genome - wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.

The research team, following up on a previous genome - wide association study by researchers at Baylor College of Medicine, investigated genetic variations in a protein called FBN - 1, which is essential for a strong arterial wall.

The challenge of genetic association studies — especially ones for complex phenotypes — is confirming statistical evidence of association with a functional assay.

«A genome - wide association study of positive emotion identifies a genetic variant and a role for microRNAs.»

Many genome - wide association (GWA) studies are currently underway for identifying genetic elements involved in complex disorders.

For a study published in the journal Biological Psychiatry, Ole Andreassen and colleagues compared genetic information from Neanderthals and modern humans and found an association between markers of human evolution and genetic risk for schizophrenFor a study published in the journal Biological Psychiatry, Ole Andreassen and colleagues compared genetic information from Neanderthals and modern humans and found an association between markers of human evolution and genetic risk for schizophrenfor schizophrenia.

Previous genome - wide association studies (GWAS) by the group have identified new genetic risk factors for the higher rates of asthma and poor response to bronchodilator medications seen in these minority populations — in many cases different from risk factors seen in prior studies conducted in European Americans.

The study entitled «A multi-national Arab genome - wide association study identifies new genetic associations for Rheumatoid Arthritis», has now been published in the prestigious medical journal Arthritis & Rheumatology; and was supported by grant from the Qatar National Research Fund, a member of Qatar Foundation.

In 2013, an expert panel made up of members of the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology published guidelines describing the genetic tests that should be performed to evaluate a patient's lung cancer.

These super-cohorts will tell us a great deal about rare variation and may even provide the power for robust studies of genetic association.

Previous studies have reported association between birth weight and future risk of developing diseases; this new work demonstrates a role for genetic variation in this correlation.

For example, genetic association studies of psychiatric disorders have located gene variants associated with the disorders, but have been able to explain only a small percentage of their heritability.

The MRC Centre for Genomics and Global Health (CGGH) is supporting TRAC by leading a genome - wide association study and population genetic analysis that integrates TRAC clinical data with genome sequencing data generated through a partnership with MalariaGEN and the Wellcome Trust Sanger Institute.

Catalyse a new generation of research on the genetic basis of drug resistance and of other forms of biological adaptation in pathogen populations, by providing a standard analytical framework for the design and interpretation of genome - wide association studies.

deCODE MI ™ The deCODE MI ™ test detects two SNPs located on chromosome 9p21, discovered by deCODE and which various genome - wide association studies have confirmed as the highest impact genetic risk factor for heart attack and coronary artery disease identified to date.

In the genome - wide association study (GWAS) published in Nature, the authors looked at over 80,000 genetic samples from schizophrenia patients and healthy volunteers and found 108 specific locations in the human genome associated with risk for schizophrenia.

Such work has become increasingly important given the expansion of genome - wide association studies identifying genetic risk factors for common diseases and corresponding efforts to commercialize genetic testing using these markers.

With funding for over a decade from the NSF and the USDA, the Rice Diversity Project supports QTL mapping, Genome Wide Association Studies (GWAS), and gene discovery using a suite of open - source genetic, genomic and bioinformatic resources developed in the McCouch lab.

Genome - wide association study (GWAS) data from a prospective cohort of warfarin - treated patients (n = 711) was also analyzed for genetic variations across the CYP4F gene cluster.

Objectives: To undertake a genome - wide association study (GWAS) to identify genetic predisposing factors for the different clinical phenotypes associated with nevirapine hypersensitivity.

The Pacific Northwest Coast proves an intriguing focus for these studies because of its association with coastal migration models and genetic ancestral patterns that are difficult to reconcile with modern DNA alone.

July 25, 2011 Two genetic variations predict second cancers after radiation treatment for children with Hodgkin lymphoma A genome - wide association study published in the August issue of Nature Medicine has found two tiny genetic variations that can predict which patients with Hodgkin's lymphoma are most likely to develop radiation - induced second cancers years after treatment.

Genome - wide association studies, or GWAS, are a popular method used by geneticists to find genetic variants associated with elevated risk for a particular disease.

Familial studies support a genetic contribution to prognosis, but little evidence has been found for a proposed association between prognosis and the burden of susceptibility variants.

Here, Kiel and colleagues perform a meta - analysis of genome - wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.

Benefits: There is no direct benefit of this study for you or your dog at this time; however, if a genetic association can be identified, a test could be developed that would predict which dogs carry the trait and may pass it on to their offspring and which dogs may develop the disease in their lifetime.

This study was in followup to an earlier study that showed a significant association between lawn chemical exposure and increased bladder cancer risk in dogs with a strong genetic risk for the cancer, i.e. Scottish terriers.

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These non-significant results are arguably due to the study's relatively small sample size for a genome - wide association study that requires multiple testing (ranging from N = 372 — 436 in the high and low trait comparison groups), making it unclear whether the same genetic variants are involved in these sub-domains.

In addition, behavior genetic studies suggest genetic factors contribute to temperamental differences among children and influence the association between temperament and child outcomes.23 Children with tendencies toward negative emotionality and poor self - regulation may be especially difficult to provide optimal care for, and their parents appear particularly likely to use less firm control over time, 24 but they are also the very children who especially need calmly - persistent caregiver efforts.

It is also likely that there are unmeasured factors responsible for many of the associations found: in particular, it is impossible with this type of study to distinguish between genetic and environmental influences on health.

In their study of monozygotic twin pairs in the Add Health sample, the associations of sleep duration with several outcomes including suicidal ideation, delinquency, and drug use were reduced to non-significance when genetic and shared environmental factors were accounted for in the model.