Sentences with phrase «for glia»

Our studies reveal previously - unknown roles for glia in pioneer - axon guidance, and suggest conserved principles of brain formation.

«This study for the first time shows increased expression of IL - 33 in AMD and further demonstrates a role for glia - derived IL - 33 in the accumulation of myeloid cells in the outer retina, loss of photoreceptors, and functional impairment of the retina in preclinical models of retina stress,» the authors note.

Not exact matches

A study in the International Society for Stem Cell Research's journal Stem Cell Reports, published by Cell Press on November 20 shows that a Sox2 protein, alone or in combination with another protein, Ascl1, can cause nonneuronal cells, called NG2 glia, to turn into neurons in the injured cerebral cortex of adult mice.

If you had to blame one thing for the mistaken impression about glia, it would have to be electricity.

The findings reveal that NG2 glia represent a promising target for neuronal cell replacement strategies to treat traumatic brain injury.

«This provides strong evidence that Müller glia are important therapeutic targets for treating degenerative eye diseases,» said Sehwon Koh, Ph.D., who is the lead author of this paper and a postdoctoral fellow in the laboratory of Cagla Eroglu, Ph.D., an associate professor of cell biology and neurobiology at the Duke University Medical Center.

«Overlooked cell key player in preventing age - related vision loss: Tree - shaped retinal cells called Müller glia may provide a new therapeutic target for treating degenerative eye diseases.»

These neurons and the synapses between them are supported by long, tree - shaped cells called Müller glia (in green), which may provide a new therapeutic target for treating degenerative eye diseases.

GBM is a devastating disease that originates from glia or their precursors within the central nervous system, and the prognosis for GBM patients is unfortunately poor, but this discovery offers new therapeutic potential.

Because the brain is like every other tissue connected to the peripheral immune system through meningeal lymphatic vessels,» said Jonathan Kipnis, PhD, professor in the UVA Department of Neuroscience and director of UVA's Center for Brain Immunology and Glia (BIG).

While the hardwired motor neuron development allows for the precise control that muscle coordination requires, the flexible development of glia makes the system more robust.

Duke Regeneration Next researchers discovered that a protein in the glia called connective tissue growth factor, or CTGF, is crucial for this process.

It is expressed all the time — even in the healthy state — and we've only described its activity after injury,» said Jonathan Kipnis, PhD, professor in the Department of Neuroscience and director of the Center for Brain Immunology and Glia.

SUSHI also visualizes synaptic clefts for the first time in slices of live tissue and reveals glia - neuron interactions and cell migration.

In fact, I stayed there for 21 years, to the point of having a permanent staff position and running my own research lab on molecular signalling and neuron - glia interactions.

«We're showing for the first time that Müller glia in the adult mouse can give rise to new neurons after injury, and these neurons have the gene expression pattern, the morphology, the electrophysiology, and the epigenetic program to look like interneurons instead of glia,» Reh said.

Jonathan Kipnis, PhD, director of the Center for Brain Immunology and Glia at the University of Virginia was a co-senior author of the study.

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AD 129 — c. 216) galena GALEX (Galaxy Evolution Explorer) Galilean satellites Galilean telescope Galileo (Galilei, Galileo)(1564 — 1642) Galileo (spacecraft) Galileo Europa Mission (GEM) Galileo satellite navigation system gall gall bladder Galle, Johann Gottfried (1812 — 1910) gallic acid gallium gallon gallstone Galois, Évariste (1811 — 1832) Galois theory Galton, Francis (1822 — 1911) Galvani, Luigi (1737 — 1798) galvanizing galvanometer game game theory GAMES AND PUZZLES gamete gametophyte Gamma (Soviet orbiting telescope) Gamma Cassiopeiae Gamma Cassiopeiae star gamma function gamma globulin gamma rays Gamma Velorum gamma - ray burst gamma - ray satellites Gamow, George (1904 — 1968) ganglion gangrene Ganswindt, Hermann (1856 — 1934) Ganymede «garbage theory», of the origin of life Gardner, Martin (1914 — 2010) Garneau, Marc (1949 ---RRB- garnet Garnet Star (Mu Cephei) Garnet Star Nebula (IC 1396) garnierite Garriott, Owen K. (1930 ---RRB- Garuda gas gas chromatography gas constant gas giant gas laws gas - bounded nebula gaseous nebula gaseous propellant gaseous - propellant rocket engine gasoline Gaspra (minor planet 951) Gassendi, Pierre (1592 — 1655) gastric juice gastrin gastrocnemius gastroenteritis gastrointestinal tract gastropod gastrulation Gatewood, George D. 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The layering within these columns was indistinguishable from the adjacent, control retina and contained cells with the appropriate morphology for their nuclear layer (rods and cones in the ONL, bipolar, amacrine, horizontal, and Müller glia in the INL, and RGCs in the GCL).

Watkins» work with glia, for example, has indicated that long - term opioid therapy may have an effect similar to that of chronic inflammation, causing glial cells to release an excess of cytokines that actually reduce the drug's effectiveness in blocking pain.

Molecular markers for retinal ganglion, amacrine, bipolar, horizontal, Müller glia, and rod and cone photoreceptor cells (Table S3) identified these cell types (Figures 5B, 5D — 5N, and S2, S3, S4, S5, S6).

We demonstrate that C. elegans possesses radial - glia - like cells key for assembly initiation.

So far, two major endogenous cell sources for neuronal regeneration have been described: the Müller glia (MG) and retinal pigment epithelial (RPE) cells.

CHIN - 1 / Chimaerin and KPC - 1 / Furin cooperate non-canonically in glia and pioneer neurons for guidance - cue trafficking.

Glia do a lot of very nice things for neurons like feed them nutrients and oxygen, hold them in place, and clean up after them.

[19] In the current study, [15] PDGF - AS mice exhibited an increased number and intensity of areas staining for reactive microglia (using Iba1) and astroglia (using GFAP), but vaccination with AFF 1 prevented nearly all of this disease - associated excess, with treated animals exhibiting only the burden of reactive glia present in similar - aged WT mice.

Early in his career, he discovered that previously enigmatic support cells, known as radial glia, serve as guides for the migration of cortical neurons in the developing brain, and showed how this process is critical for the organization of the multi-layered structure of the cerebral cortex.

The symposium is organized by the Centre for Molecular Biology and Neuroscience (CMBN), University of Oslo, to highlight the emerging importance of the roles of glia - neuronal interactions in brain function and disease processes.

Many, many more specialized cells called «glia» protect and support neurons in gray matter, and provide insulation for their delicate interconnections (called axons) in the «white matter.»

Notch signaling is essential for radial glia stem cell proliferation and a determinant of neuronal number in the mammalian cortex.

NMDA - Rs are expressed in both neurons and glia (Conti et al., 1997; Verkhratsky and Kirchhoff, 2007), and selective genetic access to these cell classes in the brain could allow for dissection of their relative role in synaptic function.