Furthermore, animal studies suggest that taste buds produce hormones that are
important for glucose metabolism and that, in rodents, taste buds decrease in number with age.
Hypoxia - inducible factor 1α (HIF - 1α), an oxygen sensor that controls the expression of various
genes for glucose metabolism under conditions of low oxygen levels, is the most well documented substrate of the von Hippel - Lindau (VHL) enzyme.
One hallmark of cancer is the accelerated metabolism, high energy requirements, and increased glucose uptake by the tumor cells, the latter being the first and rate - limiting
step for glucose metabolism [2,3].
Findings published on the National Institutes Of Health website, Metabolic Effects of the Very - Low - Carbohydrate Diets: Misunderstood «Villains» of Human Metabolism, (Manninen et al) ascertains that reducing carb intake triggers a harmless physiological state known as ketosis, where ketones flow from the liver and spare the need
for glucose metabolism providing an alternative source of fuel for the body.
I also use a dietary suplement for Diabetics called Glucuril from Phytopharmica which contains chromium, bitter melon extract and other ingredients important
for glucose metabolism.