Sentences with phrase «for high levels of expression»

Not exact matches

The PRPA has already completed substantial pre-development work at the sites, improving access, in anticipation of private development spurred by a Request for Expressions of Interest (REI) that was issued late last year and, the port authority said, «garnered a high level of response from maritime industry, manufacturing, and energy companies.»

When a single gene exists in the ancestral mutation, that would have made for higher levels of enzyme expression, would have messed up with sensory function.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

Previous studies have shown a physiologic role for vitamin D in liver function, but «it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis,» says lead author Ning Ding, a research associate in the Gene Expression Laboratory.

In addition, gastrocnemius muscles from IL - 15Rα — KO mice expressed higher levels of mRNA for the sarcoplasmic endoplasmic reticulum calcium ATPase - II (SERCA2) and lower mRNA expression and protein content of the calcium - binding protein calsequestrin (Figure 5, F and G).

A few studies have suggested that CA2 might be involved in social memory, as this region has a high level of expression of a receptor for vasopressin, a hormone linked to sexual motivation, bonding, and other social behaviors.

Dr. Moscat's laboratory, in collaboration with that of Dr. Karin at UCSD, has established for the fist time that p62 is necessary and sufficient for HCC induction in mice and that its high expression level in non-tumor human liver predicts rapid HCC recurrence after curative ablation.

High mRNA expression levels of HNF4α and ASGPR1 are shown in the enhanced hiPS - HEP cells for an extended culture time and are comparable to levels in cryopreserved human primary hepatocytes (hphep cells) that have been grown for only a short time.

If, for instance, a researcher finds that dozens of genes in a microarray are differentially expressed on a high - fat purified ingredient diet compared to a low - fat GB diet, it is tempting to conclude that gene expression was altered due to the differences in fat levels between the diets.

BTHP - 1 parental cells were transduced with the MLV vector MX - DC - SIGN and FACS sorted as a population for high levels of DC - SIGN expression.

In the 1980s, Dr. Kaufman's experience with gene transfer and engineering led him to become a founding scientist at Genetics Institute Inc., where he engineered mammalian cells for high - level expression of therapeutic proteins, such as clotting factors that are now used to treat individuals with hemophilia.

High - level expression can result under inflammatory and tolerogenic conditions in vivo, and OX40 can be maintained for a number of days under adjuvant - induced inflammatory conditions.

Dr Gilchrist said: «This study suggests that we may improve significantly on the widely used analysis methods for determining gene expression levels from high throughput sequence data: absolute quantitation offers a much sounder basis for determining changes in gene expression level, a measure widely used to determine the consequence of genetic, chemical or physical disturbances in living systems.»

In the HepG2 cells, the expression of p53 reached a maximal level with treatment of 10 nM ActD, and decreased with doses of 100 nM or higher for 6 h (Fig. 1B).

The proposal to nominate Robert - Jan Smits for our inaugural recognition of an individual's Lifetime Achievements for Science and Society is an expression of the high - esteem and reputation he has earned through thick and thin, navigating through often challenging circumstances with a level of professionalism and grace that is second to none».

In contrast, treatment with ActD (10 nM) distinctly induced the expression and phosphorylation of p53 at 3 h, reaching a maximal response at 6 h, and maintaining a high level of p53 for up to 12 h in the HepG2 cells.

In the Hepa - 1c1c7 cells, treatment with ActD (10 nM) distinctly induced the expression and phosphorylation of p53 at 6 h, and a high level of p53 was maintained for up to 12 h (Fig. 1A).

By utilizing paired genome - wide high - throughput DNA sequencing (DNA - seq) with RNA - seq, we found that gene dosage, at the level of individual genes or chromosomal «somy» (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85 % of total gene expression variation in genes with a 2-fold or greater change in expression.

(B) Liver expression of Apoc3 mRNA levels in mutant mice on a high - fat diet for 6 weeks and treated for the last 5 weeks with control or ApoC - III ASO (n = 3 — 7 / group).

«Our study suggests a therapeutic benefit for repurposing a well - tolerated inhibitor with limited toxicity to treat a specific group of ovarian cancer patients with high levels of CARM1 expression,» said Sergey Karakashev, Ph.D., first author of the study and a postdoctoral researcher in the Zhang Lab.

In five independent large cohorts in which more than 1100 total patients were followed for overall survival (Desmedt et al., 2007; Esserman et al., 2012; Kao et al., 2011; Pawitan et al., 2005; van de Vijver et al., 2002; Supplementary file 1), high expression level of MELK strongly correlated with increased rates of mortality (all p values < 0.05, hazard ratios > 2)(Figure 2D, Figure 2 — figure supplement 1D).

We considered a minimum ten fold difference in the expression levels of genes as a relevant criterion for classifying them as high and low expression genes.

High levels of gene expression were found in both strains for genes involved in growth, energy and respiration (e.g., ribosomal proteins, ATP synthase, pseudoazurin), and the C - 1 metabolic carbon such as methanol dehydrogenase, ribulose monophosphate enzymes (D - arabino -3-hexulose 6 - phosphate formaldehyde - lyase, 6 - phospho -3-hexuloisomerase), formaldehyde activating enzymes (Data S6, Fig.

The addition of sacha inchi oil slowed down glucose production in 16 (38.1 %) participants that showed a higher concentration of triglycerides before meals (fasting hypertriglyceridemia), whereas an improved expression of sirtuin - 1 (SIRT1), a gene responsible for regulating energy within the cells and coordinating cellular functions, was registered four hours after ingesting the meal enriched with sacha inchi oil, and linked to lowered levels of blood sugar measured at the same time.

With filmmakers such as Coogler and Johnson — alongside Jenkins, Waititi and other creators of handcrafted blockbusters — blazing a trail, hopefully more filmmakers will find a way to satisfy the needs of the system while also building vehicles for personal expression and achievement of craft at the highest levels.

UNESCO is bringing Education Ministers together for the» #OutInTheOpen International Ministerial Meeting: Education Sector Responses to Violence based on Sexual Orientation or Gender Identity / Expression», representing the largest gathering of Ministers and other high - level representatives to address the issue.

Avoid using some colloquial expressions, this will show that the level of your academic writing skills is rather low one in order to give you the high grade for your opinionated essay writing.

Grant 1557: High - Resolution Cytogenetic Analysis of Histiocytic Malignancies and Development of a Targeted Assay to Screen for Expression Level Changes Dr. Matthew Breen, PhD Project Goal: The goal of this project is to narrow down the search for genes playing a key role in Histiocytic Malignancies and thus move a step closer to developing targeted therapies for canine patients diagnosed with this devastating cancer.

Art for art's sake is taken to a higher level and becomes the expression of an absolute, a point where any attempt to resemble a model would be in vain because content is dissolved into form.

But these articles are a layman's expression of the high level view and are for laypeople to read.

Charles J agreed with Collins J in Livingstone v Adjudication Panel for England [2006] LGR 799 and Sanders v Kingston that whilst the Code satisfies Art 10 it is important that the restraints should not extend beyond what is necessary to maintain proper standards in public life and also that political expression attracts a higher level of protection.

Because of the parents» high levels of anxiety, stress, and need for control, individual expression is discouraged.