Sentences with phrase «for human cancer patients»

Not exact matches

«Our results suggest that engineered human intestine could provide a viable treatment to lengthen the gut for patients with gastrointestinal disorders, or patients who lose parts of their intestines due to cancer,» said Bitar.

A dozen human studies of MDMA, LSD, a powerful African drug called ibogaine and psilocybin, from so - called «magic mushrooms,» are now under way, testing the once - stigmatized drugs as treatments for not only PTSD, but also cluster headaches and addiction, as well as anxiety and depression in cancer patients.

«Data from this study serves as rationale to now include dogs with spontaneous cancers in the advancement and optimization of PMed for human patients,» according to the study, Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials.

In many human breast cancers, Numb concentration is low and this is associated with a poor prognosis for the patients.

Nagrath, director of Rice's Laboratory for Systems Biology of Human Diseases, said the new metabolic analysis indicates that ovarian cancer may be susceptible to multidrug cocktails, particularly if the amounts of the drugs can be tailored to match the metabolic profile of a patient's tumor.

«By helping us understand that lower levels of RNF125 confer resistance to BRAF inhibitors, we have a new strategy to stratify patients for currently approved therapy versus participation for human clinical trials to investigate whether targeting JAK1 will be more effective in patients whose tumors exhibit reduced RNF125,» said Keith T. Flaherty, M.D., associate professor, Harvard Medical School, and director of Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, and co-author of the study.

The use of bone marrow - derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow - and adipose - derived stem cells are being evaluated.

In a second group of experiments using human tissue from patients with pancreatic ductal adenocarcinoma, which accounts for more than 90 percent of pancreatic cancers, Zheng and his colleagues also tracked down a link between the abundance of Sema3D in those tissues and the progression of metastatic pancreatic cancer.

In his current position at The Jackson Laboratory, he has overall responsibility for the ongoing operational development of the PDX resource, which generates, banks, and distributes patient - derived xenograft (PDX) mouse models of human cancers.

For example, although early clinical trials of Listeria - based vaccines have shown that the neutralized bacterium produces only mild flulike symptoms in human patients with cervical cancer, the various methods of genetically disarming the bacteria should be explored to find the safest approach for people gravely ill with pancreatic cancer, because these patients are likely to already have weak immune systeFor example, although early clinical trials of Listeria - based vaccines have shown that the neutralized bacterium produces only mild flulike symptoms in human patients with cervical cancer, the various methods of genetically disarming the bacteria should be explored to find the safest approach for people gravely ill with pancreatic cancer, because these patients are likely to already have weak immune systefor people gravely ill with pancreatic cancer, because these patients are likely to already have weak immune systems.

Triple - negative cancers are so called because they do not express receptors for the hormones estrogen and progesterone, nor for HER2 (human epidermal growth factor 2), and hence patients with these cancers are not candidates for treatment with modern hormonal therapies or the highly effective HER2 - targeted drug Herceptin (trastuzumab).

«We found that a comprehensive exercise and diet program in a group setting can make a difference for prostate cancer patients, and the difference was greater than I expected in a short period of time,» said lead author Brian Focht, a professor of human sciences at Ohio State.

Sood and colleagues looked at samples from 80 cases of human ovarian cancer grouped according to patient stress using the National Institutes of Health's Center for Epidemiological Studies Depression scale as a surrogate marker.

Of note, 145 of all the oropharyngeal cancer patients were also tested for human papillomavirus (HPV), allowing researchers to compare possible associations between the two viruses.

«More research is needed to evaluate the efficacy of this use of a cancer medication to alleviate risk of sudden cardiac death, but we are hopeful that what we observed in mice will translate effectively to humans, providing patients and clinicians with a new paradigm for treating this common and life - threatening illness,» Dudley said.

Buoyed by these results, Dana - Farber researchers are working to create a derivative of dBET1 that can be used as a drug in human patients — and to extend the conjugate strategy for the treatment of other cancers and other genetically - caused diseases.

«If the mouse models are indicative of human disease, the combination therapy can increase the proportion of patients who respond to therapy without additional adverse side effects and can improve the quality of life for cancer patients.»

BOSTON — A heated discussion broke out here today at the annual meeting of the American Society of Human Genetics over a hot - button topic: When will we know enough about rare cancer risk genes to begin routinely testing for them in patients with a family history of cancer?

Interestingly, Myh9 is also mutated in human head and neck cancers, and low expression of myosin IIa correlates with poor prognosis for the patient,» says Fuchs.

In a 1988 paper summarizing his findings, Fiebig concluded that xenograft mice were wonderful models for broadly testing new drugs against human tumors, but they «can not be used as a clinical routine method» for predicting patient treatment.1 The idea of using xenograft mice as personal avatars for cancer patients was discarded.

Dr. Andrew Hsieh of the Human Biology Division is teaming up with colleagues at Fred Hutch and Memorial Sloan Kettering Cancer Center to make progress toward precision medicine for patients with prostate cCancer Center to make progress toward precision medicine for patients with prostate cancercancer.

GEP testing is recommended for patients with early - stage, node - negative, estrogen receptor (ER)-- positive, human epidermal growth factor 2 (HER2)-- negative cancers.

The dream of personalized treatment for cancer patients takes a major step forward today with the launch by Swedish researchers of the Human Pathology Atlas.

With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.

To uncover how groups of cancer cells achieve functional diversity (through RNA) to survive chemotherapy, Lopez - Diaz dosed dishes of human pre-cancer and metastatic breast cancer cells with the cancer drug paclitaxel for a week and then removed the drug for a few weeks, mimicking the treatment cycle for a cancer patient.

Leveraging Moderna's messenger RNA Therapeutics ™ platform, an entirely new in vivo drug modality that produces human proteins or antibodies inside patient cells, Onkaido plans to rapidly turn scientific innovation into cancer therapies that can make a real difference for patients.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

Chemotherapy is a key part of the standard treatment regimen for triple - negative breast cancer patients whose cancer lacks expression of estrogen and progesterone receptors and the human epidermal growth factor receptor 2...

A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival.

He is the principal investigator of an NCI - funded, multi-million-dollar Specialized Program of Research Excellence (SPORE) in ovarian cancer, and he is the principal investigator of a multi-million-dollar grant from the New York State Stem Cell Science program (NYSTEM) to pioneer a novel strategy of reprogramming human mature T cells and hematopoietic stem cells for generating sustained attack against ovarian cancer in patients.

Although this approach has yet to be tested in humans, this study suggests that combining two existing cancer immunotherapies can significantly boost their efficacy, resulting in better outcomes for patients.

This department provides clinicians and researchers with human and technological resources enabling the development of application - oriented projects, with the objective of improving care for cancer patients (assessment and validation of diagnostic, prognostic and patient support tools, as well as development of biomedical devices or therapeutic approaches resulting from basic research).

Human Performance and Engineering (Research) to help conduct research activities for several projects in human movement and rehabilitation for traumatic brain injury, multiple sclerosis, and cancer patiHuman Performance and Engineering (Research) to help conduct research activities for several projects in human movement and rehabilitation for traumatic brain injury, multiple sclerosis, and cancer patihuman movement and rehabilitation for traumatic brain injury, multiple sclerosis, and cancer patients.

We can envision that DAXX can serve as a precise prognostic marker in PCa and that tissue - specific shRNA delivery targeted against DAXX can be employed in the treatment of metastatic prostate cancer in patients, in particular if we discover, through additional studies, that DAXX is a marker for lethal PCa in humans.

She was the Director of the Center for Human Genetics from 2000 to 2008, Medical Director of the Clinical Cancer Genetics program from 1995 to 2012, and founded the first specialized clinic for delivery of genetic services to patients and families with hereditary cancer susceptibility in NortheasternCancer Genetics program from 1995 to 2012, and founded the first specialized clinic for delivery of genetic services to patients and families with hereditary cancer susceptibility in Northeasterncancer susceptibility in Northeastern Ohio.

I think we all agree that we over treat prostate cancer in this country compared to what you see in Europe with similar outcomes and so but I think this is where the human or the Cancer Genome Project or at least better biomarkers for looking at mutations that we already know occur in these diseases I think hopefully within the next few years every single patient who is diagnosed with prostate cancer those biopsies will be characterized and then the patients followed, hopefully watchful waiting and we'll ultimately get a correlation between what mutational events predict a rather dormant disease as opposed to a very aggressive dicancer in this country compared to what you see in Europe with similar outcomes and so but I think this is where the human or the Cancer Genome Project or at least better biomarkers for looking at mutations that we already know occur in these diseases I think hopefully within the next few years every single patient who is diagnosed with prostate cancer those biopsies will be characterized and then the patients followed, hopefully watchful waiting and we'll ultimately get a correlation between what mutational events predict a rather dormant disease as opposed to a very aggressive diCancer Genome Project or at least better biomarkers for looking at mutations that we already know occur in these diseases I think hopefully within the next few years every single patient who is diagnosed with prostate cancer those biopsies will be characterized and then the patients followed, hopefully watchful waiting and we'll ultimately get a correlation between what mutational events predict a rather dormant disease as opposed to a very aggressive dicancer those biopsies will be characterized and then the patients followed, hopefully watchful waiting and we'll ultimately get a correlation between what mutational events predict a rather dormant disease as opposed to a very aggressive disease.

These kind of mice are an extraordinary resource for modeling human disease; for instance, research has found that mice that are genetically mutated to carry the BRCA1 gene (a human breast cancer gene) behave more similarly to human cancer patients than those mice who have had a tumor physically transplanted in.

His analysis of all publicly available cancer mutations and integration with all solved computational models of human proteins has created a powerful roadmap for evaluating new mutations observed in patient tumors.

These results, also presented at the 2015 European Cancer Congress (ECC2015, abstract # 5BA) today, which involve the group of 1,626 patients with a Recurrence Score between 0 and 10, demonstrated that 99.3 percent of node - negative, estrogen receptor (ER)- positive, human epidermal growth factor receptor 2 (HER2)- negative patients who met accepted guidelines for recommending chemotherapy in addition to hormonal therapy, had no distant recurrence at five years after treatment with hormonal therapy alone.

A standardized commercial version of human anti-CTLA-4 antibodies was approved for clinical use in 2011; over 30,000 cancer patients now have received the new immunotherapy.

Insofar as we can generalize from these animal experiments to humans, they provide a potential rationale for using low - protein diets to treat cancer patients, and raise the important clinical question of how to best maintain proper detoxification in these patients.

Human patients diagnosed at higher risk for colon cancer had a 36 percent regression of rectal polyps after taking black raspberry powder for nine months.

The researchers noted that the mouse results may have implications for human health as well, as they also found an E. coli variant with the suspect genes in high percentages of human patients with colorectal cancer and irritable bowel disease.

According to Merial, this vaccine was developed jointly with Memorial Sloan - Kettering Cancer Center, one of the world's premier facilities for treating human patients.

Treatment for pets with cancer has many similarities with human cancer treatment, now more so that new drug therapies are available for animal patients.

With its internationally renowned school of veterinary medicine and its NCI - designated human cancer center, UC Davis is uniquely positioned to evaluate novel treatments for companion dogs with spontaneous tumors that may ultimately be effective in human patients with cancer.

Samples from canine patients will not only allow the researchers to identify genes responsible for breed - specific susceptibilities (such as hemangiosarcoma in Clumber spaniels and osteosarcoma in Greyhounds), but also to translate these discoveries into new and more precise diagnostics and therapeutics for both canine and human cancer patients.

If I can keep a cancer in remission to buy any amount of time for a patient while promoting the human — animal bond, I'll take it as a victory.

«This important research will measure the impact of animal - assisted therapy on pediatric oncology patients and their families, thus furthering the fields of research on human - animal interaction and integrated therapies for conditions such as cancer in children,» said J. Michael McFarland, DVM, Diplomate ABVP and Group Director of Veterinary Medical Services & Corporate Citizenship for Pfizer Animal Health.

Importantly, however, we don't view our dog patients as test subjects for cancer research, but they can help us to better understand breast carcinoma in both dogs and humans and fight it more effectively.»