Sentences with phrase «for human disease»

Historically, researchers have generated their own lines of knockout mice to serve as models for human disease, such as heart disease or cancer.

An important step in developing effective treatments for human disease is finding an effective animal model of the disease to test potential therapies.

This means findings from snakes can be applied to understanding the human body and potentially developing new therapies for human diseases, the researchers said.

Having that goal of something that is useful for human disease is definitely a driving force.

But researchers say that many other viruses could communicate with each other through their own molecular languages — perhaps even viruses that are responsible for human diseases.

«Using the fruit fly as a model [for a human disease] is extremely exciting,» he adds.

The emphasis is on developing intellectual abilities and research skills through investigations of infectious diseases of food - producing, companion, and aquatic animals, as well as animal models for human disease.

The study of small molecules also offers unique opportunities for developing novel treatments for human disease.

The finding, in zebrafish and mice, may have implications for human diseases like multiple sclerosis, in which this insulation is lost.

In 2009, he established the Center for Human Disease Modeling at Duke University, which aims to facilitate collaboration across disciplines and to develop physiologically relevant, scalable tools to study variation among human patient genomes.

The experiment was meant to prove the principle of transgenic animals, particularly dogs, who, due to their lifespan and reproductive cycle, are good stand - ins for human disease research.

«Identifying specific signatures of ribonucleotide incorporation in DNA may represent novel biomarkers for human diseases such as cancer, and other degenerative disorders.»

Hennebold is attempting to create these «knockout» models for human diseases like hereditary blindness and deafness, among other disorders.

MONTREAL» The key to finding a cure for human diseases such as cancer, Lou Gehrig's disease, inflammatory bowel disease,...

Together these experiments will systematically examine and help understand the mechanisms by which DR modulates gut function and physiology and identify novel targets for therapeutic interventions which are likely to be relevant for human diseases where intestinal permeability has been observed (e.g. inflammatory bowel disease and HIV).

That similarity allowed the researchers to use the tiny stomachs as test subjects for human disease by injecting them with Helicobacter pylori, a bacterium that targets the antrum and can cause ulcers and stomach cancer.

If such mutations exist, studying them could allow scientists to develop new interventions for human disease, Tabin said.

Fecal contamination in water is one of the most common reasons for human diseases.

«It is now clear that common risk variants fail to explain the vast majority of genetic heritability for any human disease,» they wrote in an essay, arguing that many of the hundreds of GWAS findings to date «stem from factors other than a true association with disease risk.»

The Cornell and Columbia University research team looked most closely at the rat flea because of its potential as a vector for human diseases.

This method and such piPS cells provide safer cells for personalized regenerative medicine and more effective platform for human disease modeling.

Euro - BioImaging — Extensive image data sets representing different biological scales spanning biomolecules, cells, tissues and organisms will be linked, enabling drug - target and biomarker discovery for human disease.

This is the first study to show that the repeat genome can be effectively targeted using CRISPR technology, the first use of CRISPR inhibition for a human disease, and the first use of CRISPR technology in primary human muscle cells.

Understanding the genetic factors that regulate synaptic plasticity could point to new therapeutic approaches for human diseases that disrupt synaptic connections.

4 - 1BB as a therapeutic target for human disease.

These range from the investigation of single bio-molecules and single cells to in - vivo microscopy on living animals to the development of biomaterials and diagnosis tools for human diseases.

The Disease Ontology has been developed as a standardized ontology for human disease with the purpose of providing the biomedical community with consistent, reusable and sustainable descriptions of human disease terms, phenotype characteristics and related medical vocabulary disease concepts.

«Ultimately, we have to get a human model for human diseases so that we can expand human experimental biology in an ethical way and ensure that better, safer drugs get to patients faster,» he says.

He later combined it with studies on chromatin, tissue specific gene expression and mouse models for human diseases including Type II diabetes, polycystic kidney disease as well as cancer.

Today, Zheng, associate professor of pharmacology at the University of Washington and an HHMI investigator, runs a triplicate of research agendas, all rooted in Xray Crystallography, and all aiming to find new therapeutic drugs for human diseases.

Sten Orrenius» research has focussed on Cell Biology and Molecular Toxicology, most recently on mechanisms of apoptosis and other modes of cell death and the implications thereof for human disease.

Cohen died in 1993, but Steinman went on to head the laboratory that pioneered the investigation of dendritic cells, leading to important treatments for human disease using dendritic cell - and immune - based vaccines and therapies for such conditions as graft rejection, resistance to tumours, autoimmune diseases and other infections, such as the first dendritic, cell - targeted vaccine against HIV.

In this session, we review the recent advances in the identification of non-coding mutations and structural variations that influence gene regulation and their consequences for human disease.

The mouse makes an excellent model for human disease because the organization of their DNA and their gene expression is similar to humans, with ninety - eight percent of human genes having a comparable gene in the mouse.

In his research, Schroeder uses C. elegans, an important model system for human disease, to investigate how novel cell metabolism products function as signals between individuals and within cells.

They charge the factory farming of animals with polluting the environment, and going veggie, they say, is the only real solution for both human diseases and the ills of the planet.

His «no bash, no trash» philosophy is not a «go along to get along» avoidance of conflict, but rather an appreciation that the no - kill philosophy is part of a wider understanding that ends don't justify means, whether that's killing animals to solve a shelter population problem, experimenting on animals to find remedies for human disease or bad mouthing and vilifying our opponents to achieve a desirable end.

«There are very few people in human history who get the privilege of developing a new therapy for any human disease, much less cancer.

Studying how tiny microbes thrive in harsh environments could lead to better treatments for human diseases

«We found many examples in which an entire species should have a serious genetic ailment, but instead were healthy,» said Nicholas Katsanis, Ph.D., director of the Center for Human Disease Modeling and professor cell biology and pediatrics at Duke.

However, other researchers who study domestic dogs as stand - ins for human disease are less certain that transgenic dogs will become widespread in research.

The findings may have implications for human disease, Dr Ng said.

microRNAs (miRNAs) are becoming increasingly recognized as powerful biomarkers for human disease.

But Franklin and others suspect that in their zeal to clean up, facilities may have wiped out some of the microbial complexity that makes mice useful models for human disease.

And the enrichments may make the animals better at what they do: serving as important models for human disease.

This shows that the basic mechanisms of oligodendrocyte differentiation are conserved across species and that understanding the regulation of zebrafish OPCs can contribute to the development of new treatment for human diseases.

Chan believes that using transgenic primates would narrow the gap and allow researchers to develop more effective treatments for human diseases.

This research is all aimed at tissue repair strategies, but it also may provide new in vitro models for human disease.