Pre-print: A comprehensive automated pipeline
for human microbiome sampling, 16S rRNA gene sequencing and bioinformatics processing — Luisa W Hugerth — bioRxiv
NIH recently awarded $ 8.2 million to four sequencing centers, to start building a framework and data resources
for the Human Microbiome Project.
«New appreciation
for human microbiome leads to greater understanding of human health.»
Not exact matches
The «
microbiome,» or the collection of organisms that reside within the
human body (especially the gut), has become a big new interest area
for a number of major pharma companies like Merck and smaller biotechs alike.
Using advances in genomic sequencing, the
human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of
human genotypes and phenotypes as a basis
for a variety of commercialization opportunities to help solve aging related disease and
human biological decline.
Meanwhile, we're working on our next film — due
for launch in 2018, all about what practical things that can be done from birth onwards to establish, maintain, protect and restore the
microbiome for optimal
human health.
In a study to be presented Thursday, Jan. 26, in the oral plenary session at 1:15 p.m. PST, at the Society
for Maternal - Fetal Medicine's annual meeting, The Pregnancy Meeting ™, researchers with Baylor College of Medicine, Houston, Texas and University of California, San Diego, La Jolla, California, will present their findings on a study titled, Maternal Diet Structures the Breast Milk
Microbiome in Association with
Human Milk Oligosaccharides and Gut - Associated Bacteria.
The conference will be held in co-operation with the European Milk Bank Association (EMBA), and will cover topics such as: Baby - led breastfeeding, benefits of
human milk
for pre-term infants, low milk supply, lactation hormones, allergies, the
human milk
microbiome, and
human milk banking topics and many more!
Previous posts here and other blogs have done excellent reviews of the
human microbiome and birth, so my post will serve to provide updates and pose new questions
for consideration.
Emerging research shows that bacteria are absolutely vital
for human health, and science has linked an imbalance in the
human microbiome with multiple chronic non-transmissible diseases.
Blaser, director of New York University's
Human Microbiome Program, presents a sensible plan
for reclaiming our microbial balance and avoiding calamity both as a society — he calls
for an overhaul of how drugs are prescribed — and on an individual level.
For instance, recent research strongly suggests that in modern urban populations, the
human microbiome has undergone major changes since the Industrial Revolution.
This opens the door to connecting
human microbiome samples between databases, which has the potential to expose sensitive subject information —
for example, a sexually - transmitted infection, detectable from the
microbiome sample itself,» said lead author Eric Franzosa, research fellow in the Department of Biostatistics at Harvard Chan.
«Cultural revolution in the study of the gut
microbiome:
Human gut - on - a-chip technology used to co-culture gut microbiome, human intestinal cells could lead to new therapies for inflammatory bowel diseases.&r
Human gut - on - a-chip technology used to co-culture gut
microbiome,
human intestinal cells could lead to new therapies for inflammatory bowel diseases.&r
human intestinal cells could lead to new therapies
for inflammatory bowel diseases.»
The Wyss team believes the ability of the
human gut - on - a-chip to culture the
microbiome with
human gut cells also holds promise
for the field of precision medicine, where a patient's own cells and gut microbiota could one day be cultured inside a gut - on - a-chip
for testing different therapies and identifying an individualized treatment strategy.
When the team looked
for it in data from the
Human Microbiome Project, a large - scale project to sequence the DNA of all the microbes that live in and on our bodies, they found that it was present in 73 per cent of all 466 faecal samples.
With our
human gut - on - a-chip, we can not only culture the normal gut
microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»
In this latest advance reported in PNAS, the Wyss team showed that the
human gut - on - a-chip's unique ability to co-culture intestinal cells with living microbes from the normal gut
microbiome for an extended period of time, up to two weeks, could allow breakthrough insights into how the microbial communities that flourish inside our GI tracts contribute to
human health and disease.
As noted by Dr. Vicki Ellingrod — the Chair of this session, «Current state - of - the - art research in both animal models as well as
humans point to the link between the gut microbiota and mood and anxiety models, as well as the potential
for psychiatric medications to directly affect the gut
microbiome.»
«Because Candida is a natural component of the
human body
microbiome, yeast overgrowth or infection in the digestive tract,
for example, may disrupt the gut - brain axis.
For example, when they tested the gut
microbiome from a healthy
human male the old way, they found 127 different species.
This study that has been ongoing since 2013, Study of the Impact of Long - Term Space Travel on the Astronauts»
Microbiome, Microbiome for short, investigates how space travel affects the human immune system and an individual's microbiome, which is the collection of microbes that live in and on the human body at any g
Microbiome,
Microbiome for short, investigates how space travel affects the human immune system and an individual's microbiome, which is the collection of microbes that live in and on the human body at any g
Microbiome for short, investigates how space travel affects the
human immune system and an individual's
microbiome, which is the collection of microbes that live in and on the human body at any g
microbiome, which is the collection of microbes that live in and on the
human body at any given time.
By chemically removing the gut
microbiome in zebrafish in the lab and then repopulating the gut with two to three bacterial species, University of Oregon biologist Karen Guillemin has shown that certain microbes are especially skilled at suppressing the host immune system and preventing inflammation — a discovery she thinks may have implications
for human health.
Lugdunin also shows that the
human microbiome — bacteria living on and within us — is an untapped source
for novel antibiotics.
«The more we know about the microbial communities in a given environment, the more likely it is we can reshape them to improve environmental and
human health,» said senior author Rob Knight, PhD, professor of pediatrics and computer science and engineering, and director of the Center
for Microbiome Innovation at UC San Diego.
ET: «What this data analysis pipeline, moreover, creates is motivation to look
for similar forms of gene loss in other types of symbioses, such as that between
humans and their gut
microbiomes.
However, in a new study appearing in the journal PLOS ONE, researchers have turned to analyzing the
human microbiome, the bacteria and other microbes that live on and in our bodies,
for clues about the postmortem interval of a cadaver.
Human skin surfaces are complex ecosystems
for microorganisms, including fungi, bacteria and viruses, which are known collectively as the skin
microbiome.
According to the Wisconsin team, that may be a hint that the template
for a healthy
human microbiome was set in the distant past, when food from plants made up a larger portion of diet and sugar and fat were less available than in contemporary diets with more meat and processed foods.
Also, phones are ubiquitous and come into direct contact with so much of a person's environment that they might also be valuable
for analyzing exposure to «biological threats or unusual sources of environmental microbes that don't necessarily end up integrated into our
human microbiome,» researchers noted.
«The study of ancient
microbiomes helps us understand the evolutionary history of
human health and disease,» says Professor Frank Rühli, a senior author of the study and Head of the Centre
for Evolutionary Medicine at the University of Zürich.
The researchers discovered that the ancient
human oral
microbiome already contained the basic genetic machinery
for antibiotic resistance more than eight centuries before the invention of the first therapeutic antibiotics in the 1940s.
The study has wide reaching implications
for understanding the evolution of the
human oral
microbiome and the origins of periodontal disease.
Michael Blaut, a microbiologist at the German Institute of
Human Nutrition in Potsdam, Germany, says the mouse data are «believable and remarkable,» but says he has a hard time imagining a mechanism that would account
for three compounds as chemically different as aspartame, saccharin, and sucralose leading to the same changes in the gut
microbiome.
Although amplicon has been the traditional workhorse
for studies on microbial life, the spike in
human microbiome research inspired many scientists to switch to shotgun, which is cheaper and generates more genetic information.
«Reduction in dietary diversity impacts richness of
human gut microbiota: Dietary diversity necessary
for a healthy gastrointestinal
microbiome.»
The intestinal microbiota of healthy
humans progressively develops in complexity from birth until adulthood, where a stable
microbiome is established
for the majority of an individual's adult life (Arumugam et al., 2011; Jalanka - Tuovinen et al., 2011; Durbán et al., 2012).
In recent years, there's been a boom in research on the
human microbiome, the universe of microbes that live on and within our bodies, as scientists uncover its importance
for our health.
For instance, one priority could be to increase the number and diversity of people sampled in studies of the
human microbiome.
A powerful and broader way to look
for an effect of
human genetic variation on the
microbiome is to compare twins.
The present study was designed as a way to understand how
human to
human contact influences the skin
microbiome, since contact has long been acknowledged as a major dispersal vector
for skin bacterial communities (Hamburger, 1947; Pittet et al., 2006).
For instance, the
Human Microbiome Project (HMP)(Turnbaugh et al, 2007; Peterson et al, 2009; Huttenhower et al, 2012) and MetaHIT (Qin et al, 2010) have generated maps of bacterial species abundances throughout the human body, reference genomes, and catalogs of more than 100 million microbial genes assembled from shotgun sequencing of in vivo communi
Human Microbiome Project (HMP)(Turnbaugh et al, 2007; Peterson et al, 2009; Huttenhower et al, 2012) and MetaHIT (Qin et al, 2010) have generated maps of bacterial species abundances throughout the
human body, reference genomes, and catalogs of more than 100 million microbial genes assembled from shotgun sequencing of in vivo communi
human body, reference genomes, and catalogs of more than 100 million microbial genes assembled from shotgun sequencing of in vivo communities.
Part of the NIH's Roadmap
for Medical Research, the
Human Microbiome Project will award a total of $ 115 million to researchers over the next five years.
Developing a Bacteroides System
for Function - Based Screening of DNA from the
Human Gut
Microbiome — Kathy N. Lam — mSystems
OpenBiome was founded to expand safe access to fecal transplantation
for patients with recurrent C. difficile infection and to catalyze research on the role of the
microbiome in
human health.
October 28, 2015 — A consortium of 48 scientists from 50 institutions in the United States has called
for an ambitious research effort to understand and harness
microbiomes — the communities of microorganisms that inhabit ecosystems as varied as the
human gut and the ocean, to improve
human health, agriculture, bioenergy, and the environment.
While many people have become familiar with the community of microbes that live on us, with us, and within us — the
human microbiome — the soil
microbiome is lesser known but crucial
for the fate of our planet.
The
Human Microbiome Project offers an opportunity to transform our understanding of the relationships between microbes and
humans in health and disease,» said Dr. Alan Krensky, the director of the Office of Portfolio Analysis and Strategic Initiatives (OPASI), which oversees the NIH Roadmap
for Medical Research.
Of special note today: gut microbiota species expressing orthologs of
human Ro60 might be involved in triggering and sustaining chronic autoimmunity in lupus; The portal vein blood
microbiome in patients with liver cirrhosis; A randomized clinical study suggests dietary promotion of short chain fatty acid producing gut microbes as an effective treatment
for type 2 diabetes; and the sexual dimorphism of root, flower and leaf
microbiomes in the wild strawberry plant
A clearing protocol adapted
for embryos allows deeper imaging, including zeroing in on the heart as shown here.MINGFU WUThe average
human is made up of more than 30 trillion cells, not counting the hefty
microbiome he or she carries.