Sentences with phrase «for human obesity»

Remember above how first and last place for human obesity were Louisiana and Colorado?

Now, UC San Francisco (UCSF) Diabetes Center brown fat researcher Shingo Kajimura and his team have made a discovery that leads them to believe they've found that switch and one day, it just may lead to the long - sought solution for human obesity.

Whether ghrelin proves a good target for human obesity may become clear soon.

These rats are a good model for human obesity — people, too, are either resistant or vulnerable to the condition.

Not exact matches

The Center for Human Sleep Science found that getting less than seven hours of sleep a nigh can be linked to medical ailments like cancer, obesity and poor mental health.

This allowed for the average soda size to balloon from 8 ounces to 20 ounces with little financial costs to manufacturers but great human costs of increased obesity, diabetes, and chronic disease.

11.10.2012 New Franchise for Military Veterans Tackles America's Obesity Crisis Military veterans across the nation are becoming health and nutrition activists by starting a veteran - owned franchise with HUMAN Healthy Vending — the nation's leading franchisor of socially - responsible healthy vending machine businesses.

For the infant, human milk reduces the rates of infection, allergies, obesity, diabetes, leukemia, lymphoma, SIDS, and infant mortality2.

Researchers on this project included lead author Ian M. Paul, Jennifer S. Savage and Michele E. Marini, Center for Childhood Obesity Research, Penn State College of Health and Human Development and others.

Other essential work included a determined effort to tackle equine obesity — as much a problem for the UK's pony population as for the human one.

Low levels of physical activity and inefficient sleep patterns intensify the effects of genetic risk factors for obesity, according to results of a large - scale study presented at the American Society of Human Genetics (ASHG) 2017 Annual Meeting in Orlando, Fla..

With global increase in obesity and diet - related metabolic diseases, interest has intensified in ancestral or «Palaeolithic» diets, not least because — to a first order of approximation — human physiology should be optimized for the nutritional profiles we have experienced during our evolution.

«Whether an insulating effect of obesity exists is of significance both for humans and for animal models of obesity,» the research team wrote.

Until now, hundreds of labs searching for a leptin defect or another gene that might cause human obesity had come up empty - handed.

In humans, too much fructose puts the liver at risk for conditions such as fatty liver disease, and raises the overall risk of obesity and type 2 diabetes (SN: 10/5/13, p. 18).

Dogs and cats now suffer from obesity, diabetes, heart disease, cancer and more, just like humans, and researchers are now investigating common risk factors for pets and owners

He explained that rimonabant, a drug which blocked endocannabinoid signaling at cannabinoid receptors, was on the market in Europe for the treatment of human obesity.

For example, researchers reported in a much touted 2006 Science article that they had discovered a gene variant that seemed to confer a risk for obesity, and they replicated the results in four human populatioFor example, researchers reported in a much touted 2006 Science article that they had discovered a gene variant that seemed to confer a risk for obesity, and they replicated the results in four human populatiofor obesity, and they replicated the results in four human populations.

«Obesity as defined by human standards may be healthy or even necessary for this species to thrive and reproduce,» says Rivet.

«Our results provide a large body of evidence demonstrating that the harmine drug class can make human beta cells proliferate at levels that may be relevant for diabetes treatment,» said senior study author Andrew Stewart, MD, Director of the Diabetes, Obesity and Metabolism Institute at the Icahn School of Medicine.

Kajimura is hopeful but cautious about the prospects for using these drugs to treat human obesity in the near future.

«The BDNF gene has previously been linked to obesity, and scientists have been working for several years to understand how changes in this particular gene may predispose people to obesity,» said Jack A. Yanovski, M.D., Ph.D., one of the study authors and an investigator at NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

The results suggest that drugs capable of targeting similar molecular pathways in human fat cells could one day become major tools for fighting the growing worldwide epidemics of obesity and type 2 diabetes, according to senior investigator Shingo Kajimura, PhD, an assistant professor of cell and tissue biology in UCSF's School of Dentistry.

By analyzing genetic samples for over half a million individuals as part of the GIANT research project, which aims to identify genes that regulate human body and size, researchers found more than 100 locations across the genome that play roles in various obesity traits.

«The addition of osteocalcin as a metabolic regulator may one day lead to novel therapies, but we need to understand much better how it works and how it fits into physiology before such therapies can be attempted in humans,» says endocrinologist Mitch Lazar, director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania.

Mice have proven to be a particularly good model for studies relevant to humans, Magnusson said, on such topics as aging, spatial memory, obesity and other issues.

Ancient trysts between Neanderthals and modern humans may have influenced modern risks for depression, heart attacks, nicotine addiction, obesity and other health problems, researchers said.

This image shows a structure identified as a target for obesity - diabetes (human CES1), superimposed on on a field of human fat cells with their lipids stained with a fluorescent dye.

Because humans have the «identical circadian clock machinery» as mice, adds Bass, the work has important implications for scientists studying obesity and diabetes in people.

«Obesity can not be totally pinned on food stamps,» says Jay Zagorsky, a research scientist at The Ohio State University's Center for Human Resource Research and lead author of the study, «but it certainly is related to how the program is structured.»

During 2015 Nottingham's cloned sheep underwent a series of comprehensive assessments for non-communicable diseases including obesity, hypertension and osteoarthritis — three major comorbidities in aged human populations.

«Gestational weight gain greater than the IOM recommendations has long - term implications for weight - related health,» said Elizabeth Widen, PhD, RD, postdoctoral fellow at the New York Obesity Research Center in the Department of Medicine, Department of Epidemiology, and Institute of Human Nutrition.

Now, the work has brought the researchers close to a new therapy for obesity, which they report works well in monkeys and is edging toward human testing.

Animals with gene mutations that significantly alter their circadian rhythms have shorter life spans, and circadian rhythm sleep disorders in humans can have profoundly negative effects, including increased risk for obesity, depression, cardiovascular disease and cancer.

In humans, Neuropeptide Y functions similarly to sNPF and has been studied as a possible drug target for obesity treatment.

Even TV chef Jamie Oliver jumped into the fray, calling for governments to move to make obesity a human rights issue.

The complete list is: the Food Research Center; the Center for Research, Teaching, and Innovation in Glass; the Center for Research and Development of Functional Materials; the Brazilian Research Institute for Neuroscience and Neurotechnology; the Center for Research on Inflammatory Diseases; the Center for Research and Innovation in Biodiversity and Drug Discovery; the Center for Research on Toxins, Immune Response, and Cell Signaling; the Research, Innovation and Dissemination Center for Neuromathematics; the Center for Research in Mathematical Sciences Applied to Industry; the Obesity and Co-Morbidities Research Center; the Center for Cell - Based Therapy; the Center for Metropolitan Studies; the Human Genome and Stem - Cell Research Center; the Center for Computational Science and Engineering; the Center for Research on Redox Processes in Biomedicine; the Center for the Study of Violence; and the Optics and Photonics Research Center.

Obesity in these mice resembles several important clinical features of human obesity such as weight gain and disturbance of metabolism, and this mouse model was ideal for unraveling any underlying biological mechanisms of pancreas cancer that are put in motion by oObesity in these mice resembles several important clinical features of human obesity such as weight gain and disturbance of metabolism, and this mouse model was ideal for unraveling any underlying biological mechanisms of pancreas cancer that are put in motion by oobesity such as weight gain and disturbance of metabolism, and this mouse model was ideal for unraveling any underlying biological mechanisms of pancreas cancer that are put in motion by obesityobesity.

Humans can overrule their body clocks, but at a price: People whose circadian rhythms are regularly disrupted — by frequent jet lag or shift work, for example — are more vulnerable to diabetes, obesity, cardiovascular disease, and cancer.

Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8 + T cells, white blood cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease - driving cells.

Their results could pave the way for urgently needed alternatives to bariatric surgery for treating obesity in humans — the rates of which have nearly tripled worldwide since 1975.

Working with Savage were Julie Peterson, instructor, food science and nutrition, University of Minnesota, St. Paul; Michele Marini, statistician, Center for Childhood Obesity Research, Penn State; Leann Birch, Distinguished Professor of Human Development and professor of nutritional sciences, and director of the Center for Childhood Obesity Research, Penn State; and Peter Bordi Jr., director, Center for Food Innovation, and associate professor of hospitality management, Penn State.

Viewed this way, humans can be considered to have lost two genes — one affecting uricase and the other affecting the ability to produce vitamin C — whose absence helped our ancestors during famine but, in today's world, may be increasing our risk for obesity and diabetes.

The team identified multiple germline mutations in the human genes responsible for SNRK production that were directly associated with higher body mass index, higher waist circumference and risk of obesity in a cohort of 12,000 women who participated in the Women's Health Initiative.

She is responsible for managing a grant portfolio of research projects related to human nutrition and adult obesity prevention clinical trials.

Obesity in humans is an independent risk factor for myocardial infarction, stroke, type 2 diabetes mellitus, and certain cancers (7 — 9).

SNPs in the human IL15 and IL15RA genes have been associated with muscle phenotypes (16), muscle responses to resistance training (17), metabolic syndrome (16), and obesity (18 — 20), providing additional rationale to support a role for these molecules in muscle.

In the present study, the scientists created a genetically mutant mouse model deficient in type 1A BMP - receptor (BMPR1A), a key receptor for BMP - 7 which has been shown to be associated with obesity in human populations.

Harmonising ontological descriptions of phenotype in mouse and human and improving links between mouse model data and human data, using diabetes and obesity as examples, will increase the relevance of data that is generated in mouse studies for clinical studies.

Microbes in the human gut, for instance, have been implicated in regulating immune function, obesity, mood and cognitive function — but the complex chemical and neural signals that mediate these effects are largely unknown.