Sentences with phrase «for human variation»

Not exact matches

By increasing the speed and accuracy for NGS data analysis like whole genome sequencing (WGS), our computing platform makes it easier to discover links between DNA sequence variations and human disease.»

Random variation and the survival of the fittest appeared to provide explanations of the emergence of new forms, including the human, on principles that removed the need for an intelligent creator and lawgiver.

«But Charles Darwin showed how it is possible for blind physical forces to mimic the effects of conscious design, and, by operating as a cumulative filter of chance variations, to lead eventually to organized and adaptive complexity, to mosquitoes and mammoths, to humans and therefore, indirectly, to books and computers.

Plus, the act allows for some permissible variations in nutrient content: «Such disclosures shall be treated as having a reasonable basis even if such disclosures vary from actual nutrient content, including but not limited to variations in serving size, inadvertent human error in formulation or preparation of menu items, variations in ingredients or other reasonable variations.»

The huge amount of variation between adoptions, and the gamble of entering an unenforceable agreement, involving profoundly complex human relationships, makes it almost impossible to plan for how the aftermath of an adoption will feel.

The author, a certified health and nutrition counselor who teaches whole foods cooking, enthusiastically endorses human milk for baby's best start in life, and offers nutritious, almost entirely meatless recipes, with variations for adapting each recipe for babies and children.

The scientists looked for mutations, or abnormal changes in the DNA, and filtered out normal variations in genes that commonly occur among humans.

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

The researchers measured heritability — the amount of variation in a characteristic that can be attributed to genes — for a wide variety of human traits including blood pressure, the structure of the eyeball and mental or behavioral disorders.

Among other initiatives, his group contributes to ENCODE (Encyclopedia of DNA Elements), supported by NIH to define functional genomic elements; the DOE Systems Biology Knowledgebase (KBase) for data sharing and analysis; and the internationally funded 1000 Genomes Project on human genetic variation.

Stanford's Snyder is pleased about the growing push to understand human biological variation via personal connectome and other «- ome» profiles, such as metabolomes (the total metabolites present at a given time in our bodies) and proteomes (ditto for proteins).

Adds Visscher: «This is entirely in line with theory and previous inference from SNP [variant] data, yet for some reason many researchers in human genetics and epidemiology continue to believe that there is a lot of non-additive genetic variation for common diseases and quantitative traits.»

When Pääbo's team looked at patterns of nuclear genome variation in present - day humans, it identified 12 genome regions where non-Africans exhibited variants that were not seen in Africans and that were thus candidates for being derived from the Neandertals, who lived not in Africa but Eurasia.

This indicates that some of the variation seen in contemporary humans has been present for millions of years.

«Right now, the research group is analyzing the nuclear genome the results of which could provide us with information about its relationship with the Neanderthals and about the existence of genomic variations associated with the immune system that accounts for the evolutionary success of Homo sapiens over other human species with whom it co-existed.

Since the current work was done in mice, O'Leary and Zembrzycki want to confirm the link in humans by using brain scans to measure the natural variation in the neocortical areas and search for potential links to disease.

Professor Dominic Kwiatkowski, one of the lead authors of the paper, from the Wellcome Trust Sanger Institute and the Wellcome Trust Centre for Human Genetics, said: «We can now say, unequivocally, that genetic variations in this region of the human genome provide strong protection against severe malaria in real - world settings, making a difference to whether a child lives or Human Genetics, said: «We can now say, unequivocally, that genetic variations in this region of the human genome provide strong protection against severe malaria in real - world settings, making a difference to whether a child lives or human genome provide strong protection against severe malaria in real - world settings, making a difference to whether a child lives or dies.

The study, conducted using fruit fly populations bred to model natural variations in human sleep patterns, provides new clues to how genes for sleep duration are linked to a wide variety of biological processes.

To determine what level of a toxin is safe, researchers take a dose that has no observed toxicological effect in an animal and divide it by 10 once (to account for the differences between species) and then again (to account for variations among humans» ability to handle toxins); for pesticides, the dose is then divided by 10 a third time (to allow for the extraordinary sensitivity of babies and children).

Published September 15 in Genome Biology, the study relied on new software for researchers that identifies connections between seemingly unrelated human diseases and traits through the tiny, risk - conferring genetic variations they have in common.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

Finally, Niels Rattenborg from the Max Planck Institute for Ornithology in Seewiesen hopes that «this naturally occurring variation in REM sleep during a period of brain development can be used to reveal exactly what REM sleep does for the developing brain in baby owls, as well as humans.»

In humans, glucose tolerance varies with time of day, but the mechanism responsible for the variation in insulin sensitivity throughout the day is unclear.

Hünemeier responds that her team looked for new genetic variations unique to Neandertals and other ancient humans and came up empty - handed.

The agency then lowers that dosage by a factor of 10 to account for possible variations in response between the most sensitive test animal and humans.

Although these bones are unusually thick — a fact initially used to argue for their prehistoric origin — De Groote says they aren't outside the range of normal human variation.

They have made possible wholesale scans that turn up new gene modifications and variations, and the same should prove true for the new human gene arrays, says Joseph Ecker, a plant scientist at the Salk Institute for Biological Studies in La Jolla, California, who has helped pioneer whole - genome chips for Arabidopsis.

Global warming became big news for the first time during the hot summer of 1988 when now - retired NASA climate scientist James Hansen testified before Congress that the trend was not part of natural climate variation, but rather the result of emissions of CO2 and other greenhouse gasses from human activities.

«If we can determine the reasons for variations in sleep patterns, we will gain insight into the function of sleep in mammals, including humans,» said study co-author, Niels Rattenborg, head of the Sleep and Flight Group at the Max Planck Institute for Ornithology.

In 2015, Tomasetti and Vogelstein published a widely covered Science paper that found that R mutations explain the dramatic variation in cancer incidence among human tissues better than hereditary or environmental factors — helping to illuminate why tissues in the lung or colon give rise to cancer far more frequently than tissues in bone or brain, for example.

The results also show there are considerable local variations in the preferred species, but that fishing has been highly significant for human subsistence, and the significance of fishing appears to constantly increase.

The yellow jessamine (Gelsemium sempervirens, above), for example, appears entirely yellow to humans but has broad color variation to bees.

So geneticists have been focusing on the dog as a possible model for gene searches because this lack of sequence variation may help them circumvent a frequent problem with studies in humans.

Since scientists first decoded a draft of the human genome more than 15 years ago, many questions have lingered, two of which have been addressed in a major new study co-led by a Princeton University computer scientist: Is it possible, despite the complexity of billions of bits of genetic information and their variations between people, to develop a mechanistic model for how healthy bodies function?

UCSF [University of California, San Francisco]'s Institute for Human Genetics is participating, too, looking at genome - sequence variations.

Co-author Heidi Parker, a geneticist at NHGRI, says that because humans initially bred dogs for specific traits — say, smaller body size or calm temperament — selection created a population «bottleneck» that narrowed the genetic variation in offspring, leaving them with just a few specific clusters of variable genetic regions.

For those of you who love a tall tale, the list of genetic variations that determine human height has just experienced a growth spurt.

She concluded that mutant variations of two genes may impact a critical system in humans for flushing toxic metals, such as mercury, cadmium, and arsenic, out of the body.

Through his role in the UM Center for Genome Technology, part of the Miller School of Medicine, Dr. Hedges is actively involved in the incorporation of novel genomic technologies into the process of searching for the genetic variation underlying human disease risk.

Whether the loss of mass by the glaciers is due to natural variation or is caused by human - influenced warming of the oceans is not known for sure.

Researchers are exploring the use of new technologies for uncovering genetic variations in humans and for closing gaps in the mapping of the human genome.

A powerful and broader way to look for an effect of human genetic variation on the microbiome is to compare twins.

The study for the first time estimates the minimum number of locations in the human genome — 250 to 300 — where gene copy number variation (CNV) can give rise to autism spectrum disorder (ASD).

Model simulations of 20th century global warming typically use actual observed amounts of atmospheric carbon dioxide, together with other human (for example chloroflorocarbons or CFCs) and natural (solar brightness variations, volcanic eruptions,...) climate - forcing factors.

Entire swaths of human genetic variation, however, remain to be understood and we should push toward the routine de novo assembly of genomes as opposed to simply aligning to a reference for variant discovery.

In 2009, he established the Center for Human Disease Modeling at Duke University, which aims to facilitate collaboration across disciplines and to develop physiologically relevant, scalable tools to study variation among human patient genHuman Disease Modeling at Duke University, which aims to facilitate collaboration across disciplines and to develop physiologically relevant, scalable tools to study variation among human patient genhuman patient genomes.

If this is true, then there are important implications for genetic association studies, which often rely on surveys of common genetic variation in the human genome.

However, Shinya Yamanaka's formula for iPSCs, for which he was awarded last year's Nobel Prize, uses a strict recipe that allows for limited variations in human cells, restricting their full potential for clinical application.

Dosing of mebendazole of 30 - 87 mg / kg / day in humans resulted in plasma levels of 120 -218 nM (260 nM for continuous administration) with coefficients of variation ranging from 27 to 72 %.

But Dr. David Goldstein, director of Duke University's Center for Human Genome Variation, says, «Right now we know very, very little of the genetics of the diseases that most people will get.»