What does feeding do, then,
for Hypocretin Neuron excitation?
Mignot and his colleagues identified a spontaneous genetic mutation in those animals that incapacitated a receptor in brain cells
for hypocretin.
Their search turned up a suspect: a piece of a receptor
for hypocretin resembles part of the H1N1 influenza nucleoprotein — which binds to the virus genome and plays a key role in its replication.
Using gene mapping techniques, the researchers zeroed in on a mutation in the gene
for hypocretin receptor 2.
Not exact matches
In patients with narcolepsy, their immune system destroys the
hypocretin cells located in the brain, which are important in order
for them to stay awake.
Other researchers, meanwhile, found that
hypocretin was crucial
for staying awake.
For example, orexin /
hypocretin levels increase during sleep loss (39) and orexin /
hypocretin neurons are an important component of sleep — wakefulness and feeding neural systems (40, 41).
It seems as though
Hypocretin Neurons may act as a nexus of signal input
for the appropriate synchronization of various autonomic, endocrine, and metabolic processes.
Because 1)
Hypocretins simultaneously stimulate appetite and wakefulness, particularly through orexigenic output of the melanocortin system, and subsequent release of CRH, which activates the stress response, and 2) while
Hypocretin Neurons wake us up, they also need to be quiet enough
for people to go to sleep.
And BTW, I don't frequent women's issues web sites — I have Google news set to scour the net
for anything relating to
hypocretin / orexin or hypothalamus and it snagged your last post.