Sentences with phrase «for hypoxic»

Statistical evaluation at a stringent FDR of approximately 5 % for the hypoxic - control comparison identified 119 genes whose expression was preferentially upregulated in hypoxic retinas, and 24 that were preferentially downregulated (Figure 3).

Not exact matches

So their child was hypoxic and had damage from waiting for the c - section.

When a baby is obstructed in labour at home, or born with hypoxic brain injury, the delay in transferring to a tertiary hospital may result in permanent severe disability that will persist for the rest of that person's life.

Lothar Stramma, a physical oceanographer at the Christian Albrechts University of Kiel in Germany and his associates describe the hypoxic problem as global in a paper accepted for publication in Deep - Sea Research, stating that tropical low - oxygen zones have expanded horizontally and vertically around the world, and that subsurface oxygen has decreased adjacent to most continental shelves.

Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environment.

Their study showed that the protein neuropilin - 1 (Nrp1) is crucial for the localization of TAMs inside hypoxic tumor regions, which strengthens the pro-tumoral characteristics of TAMs.

In an earlier article, Jenkins showed that females with severe hypoxic ischemic injury benefit from a combination treatment of hypothermia and NAC, which provides the rate - limiting amino acid for the primary anti-oxidant in all cells.

«We don't test hypoxic ischemic injury babies for vitamin D deficiency and we don't treat it,» says Jenkins.

The 2015 Chesapeake Bay forecast calls for an oxygen - depleted, or hypoxic, region of 1.37 cubic miles, about 10 percent below the long - term average.

The forecasts call for a mid-summer hypoxic zone of 1.46 cubic miles, a mid-summer anoxic zone of 0.26 to 0.38 cubic miles, and a summer average hypoxia of 1.108 cubic miles, all at the low end of previously recorded zones.

They play a pivotal role in regulating synaptic transmission, modulating excitotoxicity responsible for much of the neuronal damage caused by hypoxic insult in the brain [37], and are expressed in retinal photoreceptors, horizontal cells, and bipolar cells as well as the amacrine and ganglion cells of the inner retina [38 — 41].

Animals used for measurement of HIF - 1α mRNA and protein were made hypoxic for variable durations, from 0.5 to 6 h, before sacrifice.

The genes identified as differentially expressed when comparing hypoxic and control retinal samples and when comparing recovery and control retinal samples at a FDR of approximately 5 % were examined for their biologic association to GO categories.

Northern blotting analyses were performed on control and 3 h hypoxic samples to confirm that mRNA levels for P0 remained unchanged during hypoxia.

Interestingly, it has been suggested that the initial signal responsible for triggering the development of hypoxic preconditioning in the brain involves the opening of ATP - sensitive potassium channels via the activation of adenosine A1 receptors [69].

Methods: Rats were made severely hypoxic (6 % — 7 % O2) for 3 h.

The researchers calculated that around 10 to 30 percent of the lake volume is hypoxic for one to three months, which Biddanda called «substantial.»

The p38 - mediated p53 phosphorylation at Ser15 and subsequent p53 induction has been reported to be responsible for apoptosis induced by nitric oxide, hypoxic conditions, DNA - damaging agents, 1 - nitropyrene, and benzo [a] pyrene [30 - 32].

Support to date for the existence of an hypoxic niche in marrow blood stem cells came from indirect evidence such as expression of the hypoxia protein Hif - 1 and related genes and staining with surrogate markers of hypoxia.

In summary, our novel data suggest that ER - α — positive and negative breast cancer subtypes respond differently to hypoxic exposure and as a consequence, anti-HIF-1α or antiangiogenic therapies will not be suitable for both subtypes.

These data support the hypothesis that ER - α plays an important role in the hypoxic CSC response in ER - α — positive cells and that signaling through this pathway is responsible, at least in part, for the increase in CSC.

A lab at UC San Diego School of Medicine is currently investigating possible interventions to help prevent and treat hypoxic kidney injuries for kidney transplant patients.

Dormant tumor cells in a hypoxic bone marrow niche (19) will be enriched for CSC in ER - α — positive breast cancer but depleted in ER - α — negative cancers profoundly influencing the capacity for late disease recurrence.

Cancer stem cells (CSCs) in the hypoxic BM regions are blamed for the incurability of MM, because CSCs are often resistant to drugs currently used against BM cancers (including proteasome inhibitors and immunomodulatory agents).

I was getting hypoxic at very low altitudes at work and hypoxy is the term for when you are lacking oxygen at altitude and usually you'll feel hypoxic anywhere between 8,000 and 12,000 feet.

In 1924, the Nobel Laureate Otto Heinrich Warburg, determined that cancer cells have a dependency on glucose for growth and metastastic processes under hypoxic (low oxygen conditions), using glycolysis

Many disease states especially cancer is in a hypoxic state and in need of oxygen for repair and healing.

In those cases, puppies and kittens have been without oxygen (hypoxic) for too long a time and the acidity of their bodies is higher than it should be because they have been deprived of oxygen.

These hypoxic areas — virtually uninhabitable for most marine life — are a result of eutrophication, or too many nutrients from fertilizer runoff and sewage discharges finding their way into coastal waters.

Records also indicate long recovery times for ecosystems affected by hypoxic events (Danise et al., 2013).

Threats to marine biodiversity in the U.S. are the same as those for most of the world: overexploitation of living resources; reduced water quality; coastal development; shipping; invasive species; rising temperature and concentrations of carbon dioxide in the surface ocean, and other changes that may be consequences of global change, including shifting currents; increased number and size of hypoxic or anoxic areas; and increased number and duration of harmful algal blooms.

The dead zone's return was discovered by oceanographers at Oregon State University, who deployed robotic underwater gliders and other monitoring devices over the past few months to assess oxygen levels in the water.They discovered that oxygen levels on reefs previously devastated by past dead zones had dropped to 0.5 mL / L by the end of June — a far cry from the 1.4 mL / L level considered to be hypoxic for most marine life.

Hypoxic brain injuries occur when the brain only gets a small amount of oxygen that is not enough for the brain to function.

«New Trends in Hypothermia Treatment for Newborns Suffering from Acute Hypoxic Encephalopathy,» American Conference Institute's 13th Annual Advanced Forum on Obstetric Malpractice Claims (Distinguished Co-Chair), June 2014

«Hypothermia Treatment for Newborns Suffering from Acute Hypoxic Encephalopathy,» American Conference Institute's 11th Annual Advanced Forum on Preventing, Managing and Defending Claims of Obstetric Malpractice, Presentation, 2012.