This position, funded by Cancer Research UK, will explore whether manipulation of a novel antigen presentation checkpoint can enhance the repertoire of tumour antigens presented
for immune recognition.
The laboratory focuses on understanding the mechanism of peptide selection
for immune recognition by major histocompatibility complex (MHC) molecules.
Not exact matches
Those repeats often lead to slight changes in the proteins coded
for by that DNA, changes that enable bacteria to evade
recognition by the human
immune system, say Tomb and his colleagues.
Using a range of chemical and biological methods, the researchers discovered that this social fluid contains a diverse array of chemicals, including growth -, digestion -, and
immune - related proteins; nest mate
recognition cues; and a juvenile hormone, important
for regulating ant reproduction, development, and behavior.
Since T cells can only recognize neoantigens that are «presented» to them by HLA molecules of the
immune system, a key step in making the vaccine is using computer algorithms to predict which neoantigen peptides will bind strongly to the HLA molecules
for recognition by T cells.
Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of
immune cells with other cells, including antigen - specific
recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands)
for LFA - 1 and are increased in inflammatory and autoimmune disease.
Innate
immune recognition and response to cell death Kenneth RockUniversity of Massachusetts, USA 19th March 201804:15 pm Host: Falko Apel, MPIIB, Berlin Location: Max Planck Institute
for Infection Biology, Seminar room 1/2 - Campus Charité Mitte
«
For instance, efforts to block the infection - enhancing activity of these semen amyloids for STD prevention must now consider the potential effects of such interventions on sperm quality and immune recognition of male antigens.&raq
For instance, efforts to block the infection - enhancing activity of these semen amyloids
for STD prevention must now consider the potential effects of such interventions on sperm quality and immune recognition of male antigens.&raq
for STD prevention must now consider the potential effects of such interventions on sperm quality and
immune recognition of male antigens.»
It is also
recognition of the many investigators who have labored
for decades to realize the promise of the
immune system in treating cancer.»
Antibodies are long, branched molecules that have places
for recognition and binding (attachment) of the antigen on one side, and a site on the other end that can call into action other
immune responses.
Yet despite the pervasive integration of technology into various social institutions, one dimension of civil society — the courtroom — has remained relatively
immune from technology's noisy demands
for recognition.
Like the bacteria that cause gonorrhea, members of T. pallidum have multiple copies of the gene coding
for the proteins that allow them to adhere to human cells — perhaps, as in the case of gonorrhea, these genes allow T. pallidum to alter their surface proteins in order to escape
recognition by the
immune system.