Sentences with phrase «for invading cells»

Viruses have many more tricks for invading cells and replicating themselves than scientists originally imagined.

Not exact matches

Introducing human prostate cancer cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for tumor cells to invade and grow in bone.

Lagasse, based at Pitt's McGowan Institute for Regenerative Medicine, has discovered how to turn any one of the body's 500 lymph nodes — the small, oval - shaped organs where immune cells gather to fight invading pathogens — into an incubator that can grow an entirely new liver.

One reason for this is that the tumour cells invade surrounding, healthy brain tissue, which makes the surgical removal of the tumour virtually impossible.

Without the right receptor, the virus can not attach tightly enough to invade the cell and co-opt it for replication.

(D) When accounting for the reduced efficiency in adherence, the cancer cells display a similar inefficiency in their ability in invade through the collagen of irradiated matrices relative to controls.

Scientists at Barrow Neurological Institute have recently made discoveries about use of a new technology for imaging brain tumors in the operating room — a finding that could have important implications for identifying and locating invading cells at the edge of a brain tumor.

The UC team first reported how to use CRISPR in pieces of circular DNA called plasmids that can invade bacteria, but the Broad won a race to apply the method to human cells, which represents a potential billion - dollar marketplace for medicines.

Abnormal and uncontrolled production of this class of proteins, known as transcription factors, allow for cells to bypass growth control mechanisms and to develop characteristics necessary for invading surrounding tissues.

Malaria, which can be especially deadly for kids, develops when mosquito - borne protozoan parasites invade and then burst out of red blood cells to enter the bloodstream.

As more reports appear of a grim «post-antibiotic era» ushered in by the rise of drug - resistant bacteria, a new strategy for fighting infection is emerging that targets a patient's cells rather than those of the invading pathogens.

Neuroscientist Saul Villeda of UCSF homed in on one actor he thought might be responsible for some of that effect: β2 microglobulin (B2M), an immune protein normally involved in distinguishing one's own cells from invading pathogens.

HCV invades cells in the body by binding to specific receptors on the cell, enabling the virus to enter it.2 Once inside, HCV hijacks functions of the cell known as transcription, translation and replication, which enables HCV to make copies of its viral genome and proteins, allowing the virus to spread to other sites of the body.2 When HCV enters the host cell, it releases viral (+) RNA that is transcribed by viral RNA replicase into viral -LRB--) RNA, which can be used as a template for viral genome replication to produce more (+) RNA or for viral protein synthesis.

While the regulatory landscapes of ILCs are primed for a quick defense upon infection, those of T cells are minimally prepared when the pathogen invades.

For several years, the research team from the Turku Centre for Biotechnology lead by Professor Johanna Ivaska has focused their efforts on understanding how cancer cells move and invade surrounding tissFor several years, the research team from the Turku Centre for Biotechnology lead by Professor Johanna Ivaska has focused their efforts on understanding how cancer cells move and invade surrounding tissfor Biotechnology lead by Professor Johanna Ivaska has focused their efforts on understanding how cancer cells move and invade surrounding tissue.

It opens a new avenue for research on vaccines to prevent malaria parasites invading red blood cells.

Using this time - consuming approach, scientists have been able to identify functions for some of the genes necessary for the parasite to invade red blood cells, as well as some of the genes required for the parasite to later erupt from blood cells.

Similar patches have already had some positive results for the «wet» form, in which blood vessels invade and destroy the retinal pigment epithelial cells.

In its hybrid form, the protein somehow makes it more difficult for the malaria parasite to invade the blood cells.

T - cells are constantly on the move throughout the body, checking for invading pathogens and diseased cells.

In a study of around 80 samples from men with prostate cancer, scientists at the Barts Cancer Institute at Queen Mary University looked for cells that were gaining the ability to migrate and invade through the body.

Results showed that not only does anti-androgen receptor therapy reduce the ability of androgen - receptor - expressing triple - negative breast cancers to proliferate, migrate and invade, but for these cells, androgen receptor seems essential to survival.

So, for example, at the University of California in San Francisco they are trying to engineer E. coli so that it can detect cancer cells, it can invade tumors, and then once it's inside they can release toxins; and so they are putting in all sorts of genes from other bacteria to assemble this, you know, this sort of synthetic E. coli that could become basically a cancer torpedo.

«New link found between sex and viruses: A protein required for sperm - egg fusion is identical to a protein viruses use to invade host cells.»

If a previous virus invades again, the T cells can quickly kill infected cells and make chemical signals, called cytokines, to call in other immune cells for reinforcement.

Probably a number of embryonic genes, after being turned off for decades, are reexpressed in cancer cells, enabling those cells to regain their embryonic capacity to move around and invade other tissues.»

For instance, the team uncovered a new type of chemical - sensing tuft cell (which helps alert the immune system to infection or other forms of injury) that displayed markers previously thought to be exclusive to immune cells and which may help sound the alarm about allergens and invading parasites.

«What makes it particularly interesting is that the region we can show is associated with protection happens to be right up against a set of genes we know are related to how malaria invades the red blood cell,» study author Dominic Kwiatkowski of the Wellcome Trust Sanger Institute and the Wellcome Trust Centre for Human Genetics told The Post.

Therapeutic benefit has been observed in tumors invaded by T - cells, the so - called inflamed, immunogenic, or «hot» tumors, however, immune approaches for non-inflamed or «cold» tumors remain an important unmet medical need.

For the first time, scientists know what happens to a virus» shape when it invades a host cell, thanks to an experiment by researchers at Penn State College of Medicine and University of Pittsburgh School of Medicine.

Harold Varmus: Well the simplistic way to think about that is and I'm not sure this is the way it will be worked out, is to be able to take just a few cells from those early lesions and examine them genetically or for other kinds of marks on the DNA that would predict whether or not this is some - this is a lesion which might or an early stage growth that might never be able to progress, but it is also possible that every early tumor of that kind has some probability of expanding and invading and growing to become a medical problem, so getting that right will obviously be crucial because it's very difficult to say when you've diagnosed something that is an early stage tumor that it won't progress.

Macrophages, from the Greek for «eating cells,» are white blood cells that act as cellular scavengers by ingesting dying and invading bacterial cells, but they recognize and refuse to eat their own kind.

Taking the microbiome into account may be important for accurate phenotype - genotype analysis due to the increasing awareness of the impact the microbes have on different body sites, through the products they produce, their ability to protect against invading organisms, their direct interaction with the cell structures and the extracellular milieu, provoking inflammatory or immune responses, and many other effects.

Macrophages are among the first layer of defense when pathogens invade the body, and their rapid response helps to prime our immune system for a secondary, durable immune response that is specifically targeted to the offending pathogens or cancer cells.

At normal to low levels, ROS and RNS are necessary for the immune system — they are released by innate immune cell macrophages to destroy invading pathogens, and they act as innate system messengers, warning of incoming invaders.

Once they occur, mast cell tumors can quickly grow from small «skin tag» - like growths on the surface to the skin to invading full thickness of the skin, and progressing to the lymph nodes for systemic infection.