Sentences with phrase «for islet cell transplants»

The JDF Center for Islet Cell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantation.

Not exact matches

Using cells from cadavers, doctors have been experimentally transplanting pancreatic islets into humans for decades, but as many as 60 percent of the transplanted islets die immediately because they are cut off from their blood supply and are killed by an immune response due to direct injection into the bloodstream, and those that survive the transplant usually die within several months.

Combining a new hydrogel material with a protein that boosts blood vessel growth could improve the success rate for transplanting insulin - producing islet cells into persons with type 1 diabetes.

Diabetes researchers are considering various replacements for insulin injections: Transplanting new pancreatic islet cells that make insulin, coaxing the patient's own islets to regenerate, or treating diabetics early in the disease with immune - suppressing therapies to prevent their body from destroying the rest of their pancreatic islets.

Using the material and protein combination, the researchers evaluated multiple locations for implanting the islet cell clusters, the first time such a direct comparison of transplant sites has been made.

«The loss of insulin - producing beta cells leads to type 1 diabetes, making it an ideal target for cell replacement therapy,» said James Shapiro, MD, PhD, FRCSC, Director of the Clinical Islet Transplant Program, University of Alberta.

Although cord blood stem cell transplant is becoming increasingly promising, the Clinical Islet Program is not currently involved with cord blood as a treatment for diabetes.

In addition to providing an unlimited supply of cells for implantation, the PEC - Direct approach has the potential to provide other advantages relative to cadaver islet transplants such as delivering a more consistent product preparation under quality - controlled cGMP conditions, with a more straightforward and safer mode of delivery.

In addition to providing an unlimited supply of cells for implantation, the PEC - Direct approach has other potential advantages relative to cadaver islet transplants such as delivering a more consistent product preparation under quality - controlled cGMP conditions, and a more straightforward and safe mode of delivery.

To create a lasting source of insulin - producing beta cells for transplant, we are developing new methods to promote differentiation from pancreatic stem cells into healthy islets.

Whereas expensive stem cell therapies, islet cell transplants, and an array of synthetic drugs in the developmental pipeline are the focus of billions of dollars of research, annually, our kitchen cupboards and backyards may already contain the long sought - after cure for type 1 diabetes.