Sentences with phrase «for key mutations»

Not exact matches

Another biotech startup, called Z53 Therapeutics, in Cleveland, Ohio, is taking aim not at the cleft in mutated p53, but at mutations that knock out a key site for binding zinc ions in p53's core.

Touted as the key to deciphering the genetic book of life, that initial sequence has proved most useful for finding or confirming genetic mutations that cause rare diseases such as Tay - Sachs disease and Huntington's.

The mutation, in a gene called HTR2B, prevents production of the serotonin 2B receptor, a key docking point in brain cells for the neurotransmitter serotonin.

Infants were also screened for mutations in the filaggrin (FLG) gene, which codes for a key skin barrier protein.

If researchers can trace the bacterium's evolutionary history, they might be able to identify the key mutations that trigger virulence or adaptation to different habitats, for example.

This is key to using CRISPR for gene therapy to, say, repair a mutation that causes sickle cell anemia or hemophilia.

«The germline was the key tissue for the synergistic gain in longevity — we think it may be where the interactions between the two mutations are integrated,» Chen said.

Aging is a key risk factor for sAML because, over time, hematopoietic stem cells (which give rise to all other blood cell types) accumulate DNA mutations and changes in other molecules that put DNA instructions into action, such as RNA and proteins.

But most of the recent patients were infected with Bordetella strains that have mutations in the genes for two key proteins thought to trigger production of immunizing antibodies.

Researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust were able to track key mutations that cancer accumulates as it develops and spreads, without the need for invasive biopsy procedures.

The Oxford team found that that was the case for cancer cells with mutations in a key cancer gene called SETD2.

The mutation isn't in a region of the gene that codes for the SMARCAD1 protein; instead it's near a key splicing site that prevents SMARCAD1 from being made correctly, the researchers report today in The American Journal of Human Genetics.

«We have shown that a specific microRNA can drive the development of bowel cancers and is a key «worker» responsible for putting into action the instructions from many cancer - causing mutations.

Part 2 of this two - part article reviews lessons from Spark Therapeutics» pivotal program for Luxturna, a gene therapy approved for the treatment of patients with retinal dystrophy associated with confirmed biallelic mutation in the RPE65 gene, and summarize key considerations for the clinical development and commercialization of gene therapies.

«In the short - term, introducing mutations in key genes will be the most wide application of this technology, where the aim is to kill DNA, avoiding the expression of toxic proteins, or introducing mutations in genes to make crops more resistant to diseases, or genes which limit crop adaptability, and to develop androsterile plants for hybrid production.

Aug 8, 2008 Two New Predisposition Genes For Breast, Thyroid And Kidney Cancers Could Lead to More Accurate Diagnosis and Earlier Detection of These Cancers Charis Eng, MD, PhD, Sondra J and Stephen R Hardis Endowed Chair of Cancer Genomic Medicine and Chair, GMI, and her team published in the Aug 8, 2008 issue of the American Journal of Human Genetics that germline mutations in SDHB and SDHD, which play key roles in the mitochondria (the cell's power houses), predispose to Cowden and Cowden - like syndromes.

The role of new genetic pathways in cancer biochemistry (the genome mutation profiles), the identification of the key targets and their validation, as well as utilization of new knock - out or knock - in animal models for such studies are among topics that will be discussed.

BRCA1 is a key protein involved in DNA repair, and mutations that impair its function increase the risk for breast and ovarian cancer.

For each mutation, they tested how well the BRCA1 protein could perform one of its key DNA - repair functions.

The goal of our research is to provide doctors with key, additional information to choose best treatment strategies for breast cancers with novel mutations of unknown significance.

Understanding how they are regulated and what happens when mutations occur is key to developing better treatments for a variety of diseases such as Alzheimer's, Parkinson's and heart disease.

«The collector's performance is independent of key applications metrics — such as Java heap size, mutation rates, object allocation rates — and it can provide highly consistent runtime execution for applications needing any size Java heaps,» he told LinuxInsider, for example, from 1 GB to 8 TB for a single application instance.