Sentences with phrase «for luminal»

The adjuvant action of cholera toxin is associated with an increased intestinal permeability for luminal antigens

Resulting increases in permeability allow for luminal factors (intestinal contents) to access the immune system and to set off autoimmune and inflammatory processes.

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

Not exact matches

These 2D cultures also abolish the need for intraluminal microinjection of single organoids and facilitate studies of host - microbe or virus interactions or the action of microbial enterotoxins because the luminal surface is fully exposed to the mucosal medium (22,23).

This model should be a powerful tool for testing therapies for aggressive ER + breast cancers and for studying luminal cancers — the most prevalent and deadliest forms of breast cancer.

Both reviewers consider that since the functional studies were only tested in 2 basal and 2 luminal breast cancer cell lines, the sample set was too small, and testing additional cell lines for their dependency on MELK should further strengthen the authors conclusions.

Given MELK is a cell cycle regulated genes, it would be important for the authors to test whether MELK expression levels in luminal and basal cell lines (Figure 4B) is correlated with their doubling time.

GALT interacts strictly with gastrointestinal functions in a dynamic manner; for instance, by increasing intestinal permeability in replay to particular stimulations, or orientating the immune response towards luminal content, allowing either tolerance or elimination / degradation of luminal antigens, or sometimes provoking damage to the intestinal mucosa, such as in coeliac disease or food allergy.

Summarized by Suzuki (2013), «Disruption of the intestinal tight junction barrier, followed by permeation of luminal noxious molecules, induces a perturbation of the mucosal immune system and inflammation, and can act as a trigger for the development of intestinal and systemic diseases» (p. 631).

The use of soluble (fermentable) fiber in preference to insoluble (non-fermentable) fiber is sometimes advocated because most soluble fibers generate butyrate, the principle source of energy for the colonocyte, and other short - chain fatty acids.23 Short - chain fatty acids may lower the colonic luminal pH, impeding the growth of pathogens.23 The use of dietary fiber can have deleterious consequences.

Proposed causes for human IBD include defective immunoregulation of the gut - associated lymphoid tissue that may be precipitated by permeability defects, 14 infectious and parasitic agents, 15,16 and dietary allergies.13, 17 There is provocative evidence from clinical observations and animal models to incriminate normal luminal bacteria or bacterial products in the initiation and perpetuation of canine IBD.18, 19 The clinical response to hypoallergenic or elimination diets suggest that dietary factors may influence the pathogenesis of canine IBD.8 - 11 The term «hypoallergenic» refers to a diet that is generally free of additives and preservatives, and contains a hydrolyzed protein source.

The efficiency of the large intestine for dehydrating the luminal contents is dependent on close coordination between colonic motility and absorptive functions (Rolfe 1999; Rolfe et al. 2002a).

Oscar for Meaning - Making: The Lovely Bones: After a zestful adolescent girl is murdered, she goes to a luminal, in - between place in which she fails to let go and struggles in vain to help her family cope with the loss.