This poor performance is sadly typical
for lung cancer treatments: Most are effective for between 3 and 15 percent of patients.
Not exact matches
The company has been trying to win FDA approval
for Opdivo to be used as a first option
treatment for non-small cell
lung cancer (NSCLC).
Merck already has an FDA approved immunotherapy drug with KEYTRUDA, a
treatment for non-small cell
lung cancer.
The biotech specialist said that its updated phase 2 data in a study of its poziotinib candidate
treatment for non-small cell
lung cancer resulted in a preliminary confirmed objective response rate and potential progression - free survival benefit in patients with the EGFR Exon 20 Mutant form of the disease.
So Buck, you're cool with paying
for peoples» voluntary addiction, resultant
lung cancer, heart disease, emphysema and the
treatment, surgery, and resource intensive long - term skilled nursing care that all entails?
«One of the toughest challenges of
lung cancer is what to do
for patients when the
cancer comes back in an area that's been treated previously with radiation
treatment,» said James J. Urbanic, M.D., lead author of the studies and a radiation oncologist at Wake Forest Baptist.
Aaron P. Mitchell, M.D., of the University of North Carolina at Chapel Hill School of Medicine, and coauthors examined FCOIs during 2014 among 125 authors of the guidelines
for the
treatment of breast, colon, prostate and
lung cancer because those are the
cancers with the highest incidence in the U.S.
If hypofractionated radiation with curative intent can reduce the
treatment time
for lung cancer patients by half with no greater toxicity, and with equivalent — if not better — tumor control and survival outcomes, this research could result in a change in the paradigm of how a large subset of locally advanced NSCLC patients are treated.»
The Chinese trial will enrol patients who have metastatic non-small cell
lung cancer and
for whom chemotherapy, radiation therapy and other
treatments have failed.
Since the
Lung Cancer Mutation Consortium trial began in 2009, many patients are now tested
for mutated or altered genes before
treatment.
«There has been a tremendous effort over the past several years to block EGFR as a
treatment for lung cancer, but this therapy only works in a small subset of patients.
«Blocking both of these proteins could be a
treatment that is beneficial
for the majority of
lung cancer patients,» said Dr. Habib, Associate Professor of Neurology and Neurotherapeutics with UT Southwestern's Peter O'Donnell Jr..
«We urgently need new
treatments for lung cancer patients, and this research suggests we can boost the effectiveness of an existing drug, rather than switch to another new expensive
treatment.
«Process to help personalize
treatment for lung cancer patients developed.»
A one - two combo punch using two currently available drugs could be an effective
treatment for the majority of
lung cancers, a study by scientists with UT Southwestern's Simmons
Cancer Center shows.
«Although some non-small cell
lung cancer patients have increased benefit of targeted therapy or immunotherapy instead of chemotherapy,
for some groups of patients with NSNSCLC, chemotherapy has been the standard
treatment for more than 30 years,» Gandhi notes.
This pre-clinical study from Professor Mazzone and his colleagues reveals a new molecular axis that may offer interesting therapeutic opportunities
for the
treatment of pancreatic
cancer, breast
cancer and
lung cancer, among others.
«FDG PET shows tumor DNA levels in blood are linked to NSCLC aggressiveness: Insights derived from FDG PET could improve
treatment selection
for patients with advanced non-small cell
lung cancer.»
Phase I / II clinical trial results reported at the American Society
for Clinical Oncology (ASCO) Annual Meeting 2015 show promising results
for investigational drug brigatinib against ALK + non-small cell
lung cancer (NSCLC), with 58 of 78 ALK + patients responding to
treatment, including 50 of 70 patients who had progressed after previous
treatment with crizotinib, the first licensed ALK inhibitor.
Few existing
treatments offer durable survival benefits
for patients whose NSCLC has spread past the
lungs, due in part to the aggressive nature of
lung cancer and its propensity to progress, even following
treatment.
Multiplexed genetic screening
for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker - guided
treatment is cost - effective compared with standard chemotherapy
treatment without any molecular testing in the metastatic non-small cell
lung cancer (NSCLC) setting in the United States.
Pembrolizumab is set to become a new option
for first line
treatment of patients with advanced
lung cancer and high PD - L1 expression, according to the results of the phase III KEYNOTE - 024 trial presented at the ESMO 2016 Congress in Copenhagen and published in the New England Journal of Medicine.
«Potential new
treatment approach
for lung cancer.»
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the preferred
treatment option
for patients with advanced non-small cell
lung cancer (NSCLC) who have mutations in the EGFR gene.
This will establish sequential crizotinib followed by a second generation ALK inhibitor as the standard
treatment for patients with metastatic ALK positive
lung cancer.»
P: We found discodermolide [a drug from Discodermia, a sponge found in the Caribbean, the Bahamas, and the Gulf of Mexico], and it's gone through phase I clinical trials
for treatment of solid tumors such as ovarian, pancreatic, breast, colon, or
lung cancers.
In the group that received targeted
treatment for ALK - positive
lung cancer, each category of tumor reduction was associated with corresponding gains in PFS and OS.
«This study demonstrates the value of testing
lung cancer tissue
for an ALK rearrangement, and it underscores the potential of
cancer genomics to target
cancer treatments to each patient,» says the study's senior author, Pasi A. Jänne, MD, PhD, who is the director of the Lowe Center
for Thoracic Oncology of Dana - Farber.
«First - line immunotherapy
treatment can improve survival
for subset of
lung cancer patients: Results of phase III global clinical trial show that 75 percent of stage IV
lung cancer patients with both complex tumor mutations and PDL - 1 positive status respond to nivolumab.»
Right now, the tests, which are available from several companies, mostly aid in
treatment decisions
for people already diagnosed with a particular form of
cancer, such as prostate or
lung.
Lung cancer in particular has become the «poster child»
for how research and
treatment have changed, says Charles Swanton, a research oncologist at the Francis Crick Institute in London, England.
Treatments for diabetes, smoking, Alzheimer's disease and
lung cancer are just a few of the potentially lifesaving cures Scientific American has chosen to highlight in this year's roundup of drugs you've never heard of, despite their potentially huge impact on global health.
Knowing more about the activation process has led researchers to be able to induce greater vulnerability by
cancer cells to an existing first - line
treatment for cancers (mainly
lung) driven by a receptor called EGFR.
Although she never received any medical or surgical
treatment for the deadly
cancer invading her
lungs, six weeks after starting psychosynthesis, her tumors began to shrink.
«Rapid advancements in genetic testing offer new
treatment options
for patients with advanced
lung cancer.
«But even more importantly,
for patients, our ability to identify the similarities could allow
treatments for other
cancers like
lung to be used
for certain breast
cancers down the road.»
Moving forward, they plan to continue testing derivatives of HIPP
for the
treatment of colon
cancer and also see if their findings extend to breast,
lung, ovarian and prostate
cancers.
Biopsies of pulmonary lesions are essential
for increasing the accuracy of diagnosis and
treatment for respiratory illnesses such as
lung cancer.
«
For about 80 percent of our patients with lung cancer, we don't have tests like [the one for] ALK to tell us what treatments will work best,» Shaw sa
For about 80 percent of our patients with
lung cancer, we don't have tests like [the one
for] ALK to tell us what treatments will work best,» Shaw sa
for] ALK to tell us what
treatments will work best,» Shaw says.
«We wanted to look at the patients» tumor and immune system prior to
treatment and examine it again after
treatment for changes,» said Patrick Forde, first author and co-principle investigator of the trial and a
lung cancer oncologist in the Bloomberg ~ Kimmel Institute of Cancer Immunoth
cancer oncologist in the Bloomberg ~ Kimmel Institute of
Cancer Immunoth
Cancer Immunotherapy.
The therapy, reported in the Aug. 17 issue of Nature Communications, offers the hope of an effective
treatment for intractable metastatic
cancers including those of the colon and
lung.
The drugs are already approved
for treatment of patients with advanced breast
cancer as well as ovarian, pancreatic and certain
lung cancers.
Cancer Research UK scientists have found a drug combination that can trigger the self - destruct process in lung cancer cells — paving the way for new treatments, according to research that will be presented at the National Cancer Research Institute (NCRI) Cancer Conference in Live
Cancer Research UK scientists have found a drug combination that can trigger the self - destruct process in
lung cancer cells — paving the way for new treatments, according to research that will be presented at the National Cancer Research Institute (NCRI) Cancer Conference in Live
cancer cells — paving the way
for new
treatments, according to research that will be presented at the National
Cancer Research Institute (NCRI) Cancer Conference in Live
Cancer Research Institute (NCRI)
Cancer Conference in Live
Cancer Conference in Liverpool.
«Programs that provide
treatment for lung cancer also must measure their performance actively and carefully in order to improve the quality of care and improve patients» chances of survival.»
Researchers at Norris Cotton
Cancer Center have found an antibody that may be used in future treatments for recurrent small - cell lung cancer, which currently has no effective th
Cancer Center have found an antibody that may be used in future
treatments for recurrent small - cell
lung cancer, which currently has no effective th
cancer, which currently has no effective therapy.
«Antibody - targeted
treatment developed
for recurrent small - cell
lung cancer.»
«It takes too long
for patients who have suspected
lung cancer to get final
treatment, and too many patients skip vital steps needed to decide the best possible
treatment,» said Dr. Osarogiagbon.
«Researchers inhibit tumor growth in new subtype of
lung cancer: Insight into tumor suppressing and tumor promoting mechanisms offers potential
for new
treatments.»
«
Lung cancer care is complicated, and all key specialists must be actively engaged early on with each patient to determine the best sequence of tests and
treatment for each individual,» said Dr. Osarogiagbon.
Using only patients who had surgery
for suspected
lung cancer, the researchers examined how long it took to begin care and what steps were taken to determine appropriate
treatment.