Sentences with phrase «for lymphocytes»

The complete blood count panel showed no group changes in percentage of each type for lymphocytes, neutrophils, eosinophils and basophils.

LPA is produced by a specific type of stromal cells, which forms a scaffold for lymphocytes to crawl around within the node.

In lymph nodes, a particular type of stromal cells that forms a scaffold for lymphocytes to crawl around within the node normally secretes an enzyme called autotaxin, which is responsible for the production of the lipid signaling molecule, lysophosphatidic acid (LPA).

«The work provides another important role for lymphocyte proliferation, to set up the conditions needed for changing function,» Biron said.

After 5 hr stimulation with PMA, ionomycin and IL - 23, cells were first gated for viability and then for lymphocyte size and granularity by forward and side scatter.

Cells were first gated for viability and then for lymphocyte size and granularity by forward and side scatter.

Not exact matches

He said that the most exciting arenas of immunology today include new strategies for vaccines and studies of regulatory T lymphocytes and the innate immune response, which is essentially the most general form of attacking pathogens.

Histone deacetylase (HDAC) inhibitors have shown promise in «flushing out» HIV from latently infected cells, potentially exposing the reservoirs available for elimination by cytotoxic T lymphocytes (CTL), also called killer T cells.

«While the presence of lymphocytes in tumors is often associated with better clinical outcomes, this research adds clarity on the diversity of T cells within the tumor environment and their influence on ovarian cancer outcomes,» says first author Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director, M. Steven Piver Professor and Chair of Gynecologic Oncology, and Executive Director of the Center for Immunotherapy at Roswell Park.

The overlap and density of these lymphocytes within the tumor and peripheral blood offer novel prognostic biomarkers for this deadly disease,» adds Richard Koya, MD, PhD, Associate Director of the Roswell Park Center for Immunotherapy and Director of the Institute's Vector Development and Production Facility.

However, for the NOS group the reverse was seen, with overcrowding being associated with an increased incidence of this type of HL, while deprivation seemed to have no effect on the incidence of the mixed cellularity and lymphocyte - rich sub-types.

The team says their method could be applied to lymphocytes taken from bipolar patients» blood samples, to find out whether specific individuals would be good candidates for lithium therapy.

Overall, the presence of B lymphocytes was associated with increased tissue proliferation, reduced cell death and a more supportive environment for wound healing.

For many years, Dr. Ohashi's team has been studying tumor - infiltrating lymphocytes (TILs), which are the cell type known to kill cancer cells.

Recent studies from the VIC and other centers have identified several unsuspected roles for B lymphocytes, including the secretion of powerful anti-inflammatory molecules.

The scientists conclude that the study reveals an essential function for CTCF in the orchestration of transcriptional changes during the terminal differentiation of B lymphocytes and advances understanding of the mechanisms that regulate the immune response.

While a postdoctoral fellow at the Naval Medical Research Institute in Bethesda, he developed a system for large - scale efficient culture of lymphocytes that has proved to be the foundation for over 35 early phase clinical trials of adoptive immunotherapy.

A research group led by Osaka University and the University of Turku has found for the first time that a lipid called lysophosphatidic acid (LPA) plays a vital role in regulating lymphocyte motility within lymph nodes.

Thus, this cDNA derives from a gene (oct - 2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell - specific transcription factor exists and its amount is controlled through messenger RNA availability.

Although GMCSF is mostly known for its role in inflammation, Dr. Merad's laboratory discovered that GM - CSF is produced in the normal gut by specialized cells called innate lymphocyte cells (ILCs) in response to microbiota signals.

A group of people at Osaka University (Eiji Umemoto [Associate Professor, Laboratory of Immune Regulation, Osaka University Graduate School of Medicine] and Masayuki Miyasaka [Specially Appointed Professor, Institute for Academic Initiatives]-RRB- and University of Turku, Finland (Akira Takeda, Postdoctoral researcher at MediCity Research Laboratory) has found for the first time that a lipid called lysophosphatidic acid (LPA) plays a vital role in regulating lymphocyte motility within lymph nodes.

For reasons still not quite understood, when the lymphocytes repopulate, those involved in attacking the myelin sheath seem less likely to recover.

«PD - L1 allows immunosuppressive lymphocytes to suppress cytotoxic T cells, but it's also their «Achilles heel,»» said Karin, who is also the Ben and Wanda Hildyard Chair for Mitochondrial and Metabolic Diseases.

T lymphocytes and NH cells in the asthmatic lung produce proteins named interleukin (IL)-5 and IL - 13 that are responsible for severe airway inflammation.

B cells, the lymphocytes best known for making antibodies, live a complex life.

Researchers carried out the study by chemically inhibiting the production of antibody - producing white blood cells (B lymphocytes) in broiler chicks, before introducing C.jejuni infection at the age of three weeks and then monitoring bacteria levels in the gut for the next nine weeks.

This gene codes for part of a protein complex, called the IL - 7 receptor, that is found on the surface of certain lymphocytes and is important for their maturation.

Platinum - based therapies are being tested in clinical trials for triple - negative breast cancer, and evaluation of tumor - infiltrating lymphocytes is an important factor in determining response to this treatment.

Reasons for resistance to transformation of mature lymphocytes are unclear, but may involve an unknown mechanism that ensures the diversity of the TCR repertoire and thus limits clonal outgrowth [54].

I am interested in gaining a better understanding of why this class of innate lymphocytes are so critical for protection against S. pneumoniae in mice, with the ultimate goal of harnessing the potential of these cells for human therapeutics.

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

Many leukemias exhibit mixed - lineage patterns of gene expression, for example of both macrophage and lymphocyte genes.

T lymphocytes are required for the rejection of corneal allografts, as athymic, T cell - deficient nude mice do not reject corneal allografts (3).

Traversari C, van der Bruggen P, Van den Eynde B, Hainaut P, Lemoine C, Ohta N, Old L J, Boon T. Transfection and expression of a gene coding for a human melanoma antigen recognized by autologous cytolytic T lymphocytes.

The first monoclonal antibody for cancer (rituximab, Rituxan, directed to CD20 on B lymphocytes) is approved for the treatment of non-Hodgkin lymphoma by the FDA.

The symposium features presentations by Philippa Marrack and John Kappler talking on the T cell repertoire; William Paul on interleukin 4 as a prototypic immunoregulatory cytokine; Timothy Springer on lymphocyte trafficking; Pamela Bjorkman on structural studies of MHC and MHC - related proteins, and Jack Strominger on peptide presentation by class I and II MHC proteins; Thierry Boon on genes coding for tumor rejection antigens, including the first tumor antigen, MAGE - 1; and Philip Greenberg on the modification of T cells for adoptive therapy by retroviral - mediated gene insertion Since then, the symposia series has attracted leading immunologists in the cancer vaccine and antibody fields, providing them with a comprehensive view of the promises and challenges in the development of cancer immunotherapies.

Anti-cytotoxic T - lymphocyte antigen - 4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment.

Our technological expertise ranges from the most fundamental approaches to study membrane transport in lymphocytes and dendritic cells (subcellular compartmentalization, intravital microscopy, phagosomal functions), the systematic analysis of gene expression and it regulation (RNAseq, Chip Seq, proteomics) and physiological and pathological immune responses (mouse models for cancer immunity, immunomodulation / vaccination, human clinical studies in cancer).

Gaugler B, Van den Eynde B, van der Bruggen P, Romero P, Gaforio JJ, De Plaen E, Lethé B, Brasseur F, Boon T. Human gene MAGE - 3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

c - Rel is essential for B lymphocyte survival and cell cycle progression.

For intracellular cytokine staining, lymphocytes were cultured in 96 - well flat - bottom plates at 1 × 106 cells / well in 200 μl RPMI 1640 supplemented with 10 % FBS in the presence or absence of GP33, GP276, and NP369 peptides.

For example, one could stain for cellular markers and activation markers to infer the activity status of T lymphocyFor example, one could stain for cellular markers and activation markers to infer the activity status of T lymphocyfor cellular markers and activation markers to infer the activity status of T lymphocytes

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA - A2 melanomas.

Studies in CD8 knockout (KO) and perforin KO mice demonstrated that CD8 + cytotoxic T lymphocytes (CTL) are unnecessary for the rejection of corneal allografts in mice (8, 9).

If sufficient 1,25 - dihydroxyvitamin D is produced, it may exert paracrine effects on surrounding T lymphocytes, thereby regulating the tissue - specific immune responses.10 Some support for this hypothesis comes from recent experiments showing that mice fed diets high in vitamin D had significantly fewer clinical and pathological signs of EAE than mice fed a vitamin D — deficient diet.37 Central nervous system levels of 1,25 - dihydroxyvitamin D, but not blood levels, were higher in supplemented mice than in vitamin D — deficient mice and correlated inversely with disease severity.

This project will determine whether specific populations of lymphocytes are required for RGC death in glaucoma.

They started off with mature T - lymphocytes which were specific for a type of skin cancer and reprogrammed them into iPSCs with the help of «Yamanaka factors».

The laboratory of Vincenzo Cerundolo is the first group to report the use of tetrameric soluble class I / peptide complexes (tetramers) for the identification of tumor - specific cytotoxic T lymphocytes (CTLs), and subsequently shows that these novel reagents allow rapid and accurate analysis of human CTL responses.