Sentences with phrase «for mechanisms of disease»
This quintessential environmentalist's quest for mechanisms of disease evolved into a philosopher's search for health
https://www.scientificamerican.com/ Not exact matches
And a third, different kind of gene therapy from Spark Therapeutics — to treat a rare inherited form of blindness — is likely to be approved by the end of 2017, too, making this year a landmark for treatments that manipulate the body's own biological mechanisms in novel new ways to fight deadly diseases.
In those areas that we have mapped, it typically takes us a few hours to go from a mechanism - inspired idea for treating a disease to knowing the companies that might have relevant clinical and preclinical assets to license, the companies from whom a candidate could be commissioned, trial designs and endpoints, competing and complementary agents, current and future standard of care, market size, comparable pricing, financing strategy, and potential acquirers, all meant to enable a thoughtful first - pass assessment of whether an idea could be worth a much deeper assessment.
MIN - 102 has a unique mechanism of action for X-ALD, a genetic disease characterized by progressive neurologic deterioration with no available pharmacological treatment.
Minoryx harnesses its unique mechanism of action for potential use in X-ALD, a genetic disease characterized by progressive neurologic deterioration with no available pharmacological treatment.
«With the Immunoscape platform, we are seeking to develop a molecular map of inflammatory diseases that will help us identify and characterize disease mechanisms,» Jessica Mega, chief medical officer for Verily, said in Monday's announcement.
The Global Burden of Disease Study 2010 predicted that sugar sweetened drink consumption contributes a relatively small amount to UK population morbidity (28000 disability adjusted life years) compared with low fruit and vegetable consumption (1130000 disability adjusted life years).59 Using revenue from a sugar sweetened drink tax to reduce the prices of fruit and vegetables is a potential mechanism for further improving population health.60
In May 2000, the Archives of Disease in Childhood published research showing that scrotal temperature is increased in boys wearing disposable diapers, and that prolonged use of disposable diapers will blunt or completely abolish the physiological testicular cooling mechanism important for normal spermatogenesis.
It occurs because of the spontaneous release of pyrogens, our body's natural defense mechanism for fighting disease.
For 50 years, the fundamental principles and mechanisms of the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.
«The discovery of HDMP in humans means that for the first time we are seeing an important mechanism in the process which causes the disease.
«Given this mechanism, ataluren offers the potential for a new therapeutic approach for multiple nonsense mutation genetic disorders by targeting the underlying cause of the disease.»
Right now the research team is teasing out further details of the disease mechanism since this will steer researchers on a path towards much - needed treatment for motor neuron diseases.
«It could be one of the mechanisms for genetic inheritance of disease — a route we haven't thought of before,» says Spector.
«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.
The existence of two mechanisms would make sense for what we know about biology: Salt is necessary for life, but too much salt can kill you, and not just in the sense that excess salt in the diet may be behind some cases of heart disease.
«How the microbiome is linked to autoimmune disorders: Discovery of new mechanism in the gut microbiome has implications for inflammatory bowel disease.»
Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.
Gaining a better understanding of the underlying disease mechanisms could offer the possibility of developing new and better treatments for lupus and other autoimmune conditions in the future.
Tuncay Baubec, professor at the Department of Molecular Mechanisms of Disease at the University of Zurich, and his team have shown that one particular protein plays an important part in this process: The DNA methyltransferase 3A (DNMT3A) enzyme is responsible for positioning the methylation to the right place on the DNA.
Professor Nutt said increasing our knowledge of the mechanisms that controlled the immune response was vital for understanding how immune and inflammatory diseases arise and, ultimately, developing more effective treatments.
«With all our medications, we're attempting to develop an understanding of the mechanism of the disease and an understanding of which patients will respond, so that we can treat those patients who will respond and not those who won't,» comments Richard Scheller, executive vice president of research for Genentech.
«Our study reveals a new mechanism that could be harnessed for biological therapies for lupus and other autoimmune diseases, where the immune system mistakenly targets the body's own cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine at NYU Langone.
Disgust is the mechanism for doing this — causing us to shun people who violate the social conventions linked to disgust, or those we think, rightly or wrongly, are carriers of disease.
The next objective of the researchers is to decode the action mechanism of TREX2 in the development and maintenance of psoriasis, so as to design new therapeutic strategies for the treatment of this disease.
«We were very surprised to find alterations in proteins that are responsible for RNA splicing in Alzheimer's, which could have major implications for the disease mechanism,» says Allan Levey, MD, PhD, chair of neurology at Emory University School of Medicine and director of the Emory ADRC.
This basic fact makes it difficult for researchers to discern the underlying mechanism of the disease: «It's very difficult to figure out what's wrong, because the bone marrow is nearly empty of these cells,» said Bessler, the director of CHOP's Pediatric and Adult Comprehensive Bone Marrow Failure Center.
Vitamin D also reduces inflammation, an underlying mechanism for obesity related development of coronary artery disease, says Raed.
Researchers have found that revulsion activates the brain's harm - avoidance center, invoking notions of cleanliness and moral purity as a primal mechanism for avoiding disease.
The authors note that while large, international, multi-lateral funds exist for global health delivery, there is no significant pooled funding mechanism for research and development to complement existing but limited R&D funding for a wide range of diseases.
«The practice of the Wim Hof Method may lead to tonic changes in autonomous brain mechanisms, a speculation that has implications for managing medical conditions ranging from diseases of the immune system to more intriguingly psychiatric conditions such as mood and anxiety disorders,» said Diwadkar, professor of psychiatry and behavioral neurosciences.
Understanding the mechanisms of inflammation in rheumatoid arthritis is important for the design of new therapies for this disease.
However, many industry insiders say these changes are opening up unique opportunities for researchers who focus on translating basic science into real - world cures and are eager to explore the molecular mechanisms of disease, test hypotheses, and do work that benefits patients.
«If indeed this turns out to be one of the main mechanisms for disease, we now have a whole host of diagnostic and therapeutic techniques that we didn't have before.»
This potential common mechanism could help explain why physical exercise and diet, classic ways of reducing risk of heart disease, for example, are also thought to improve mood and help depression.
By pairing a receptor that targets neurons with a molecule that degrades the main component of Alzheimer's plaques, the biologists were able to substantially dissolve these plaques in mice brains and human brain tissue, offering a potential mechanism for treating the debilitating disease, as well as other conditions that involve either the brain or the eyes.
«Further work in our lab will be aimed at understanding the detailed mechanism of how these proteins regulate editing, in turn providing an inroad to developing therapeutics that modulate editing for the treatment of human diseases.»
Mindfulness may offer an active coping mechanism for mothers faced with the stress of having a newborn diagnosed with congenital heart disease (CHD).
But a serendipitous discovery may someday give doctors a new countermeasure against the disease: Researchers report in tomorrow's Science that they have identified a possible mechanism of action for «lethal factor» (LF), a toxic protein produced by the anthrax bacillus that is thought to be one of the principal causes of death in infected individuals.
The prevention of dilated cardiomyopathy in a mouse model by feeding a high - fat diet signals an advance in the understanding of the mechanisms involved in heart disease and has implications for the future development of treatments for this condition.
«So though this is a fundamental discovery of this mechanism how the bacterium causes disease, it provides a lot of potential for field application.»
With the data provided by the FLI researchers, scientists around the world may now set targeted mutations to investigate the relevance of single genes for aging, in order to better understand regulating mechanisms and, eventually, develop new approaches for therapy or prevention of aging - related diseases.
But for a host of other risk factors — such as cigarette smoke and certain bacterial infections — the disease - causing mechanism is unclear.
«Future research to clarify the mechanisms underlying the link between PTSD and heart disease in Vietnam veterans and other groups will help to guide the development of effective prevention and treatment strategies for people with these serious conditions.»
The researchers conclude in their paper: «Ultimately, knowledge of the mechanisms by which thirdhand smoke exposure increases the chance of disease development in exposed individuals should lead to new strategies for prevention.»
«Given that every newborn in the United States is screened for a number of inherited metabolic disorders, including MMA, there is a critical need for better understanding of the disease mechanisms and therapies to treat them.»
Genotoxicity is associated with the development of diseases and is a critical mechanism responsible for many types of cancer caused by smoking and secondhand smoke exposure.
Dr. Alan S. Cross, Professor of Medicine at University of Maryland School of Medicine, who was not involved in the research, shared his input: «This is a major conceptual breakthrough in our understanding of infection and immune disease mechanisms and may have implications for novel approaches to the treatment of other diseases characterized by cytokine storm.
Kidney disease will be the main application of the research working in collaboration with the Centre for Kidney Research and Innovation (CKRI), but the team believes that Sodium MRI can also be used for more accurate diagnosis and monitoring of other diseases, and perhaps will give new insights into disease mechanisms as sodium management is important in the brain, lung, liver, and musculoskeletal system.
They say this latest study raises questions about whether treatments that decrease the frequency or severity of migraine may reduce later life vascular risks, and conclude by saying «what little evidence we do have suggests the need for therapeutic restraint [to prevent cardiovascular risk] until we have a better understanding of the mechanisms underlying the link between migraine and vascular disease.»