Sentences with phrase «for mechanistic study»

The results are «important both for mechanistic study and also for potentially therapeutic developments,» said Yadong Huang of the University of California, San Francisco, and the Gladstone Institute of Neurological Disease, who also was not involved in the work.

Introduced in 1992 by Kim and Chung (1), spinal nerve L5 / L6 ligation (SNL) in rats has become well recognized and accepted as an animal model for mechanistic studies of peripheral neuropathy and for screening of novel analgesics.

Visit the Frontiers of Photobiology: Nobel Lecture by Aziz Sancar (The Nobel Prize in Chemistry 2015 «for mechanistic studies of DNA repair») Nobel Lecture by Roger Y. Tsien (The Nobel Prize in Chemistry 2008 «for the discovery and development of the green fluorescent protein, GFP») Interviews with Johann Deisenhofer, Robert Huber, Hartmut Michel (The Nobel Prize in Chemistry 1988 «for the determination of the three - dimensional structure of a photosynthetic reaction centre»)

Not exact matches

«Mechanistic finding may help develop treatment for Ice Bucket Challenge disease: Study blames a fault in the cell's machine that cuts and pastes genetic instructions for a deadly motor neuron disease.»

«It makes it much easier for researchers working with barley to be focused on attainable objectives, ranging from new variety development through breeding to mechanistic studies of genes.»

«This study shows, that there is a mechanistic explanation for why fish may move, faced with a choice, and now we have a way of testing it,» Johansen said.

A new study published in Proceedings of the National Academy of Sciences and led by researchers from the University of Pennsylvania now offers the first mechanistic explanation for why this is the case.

These findings also suggest a mechanistic basis for potential treatments involving the painless electrical stimulation of the amygdala, which are currently being studied in ongoing clinical trials.

Since scientists first decoded a draft of the human genome more than 15 years ago, many questions have lingered, two of which have been addressed in a major new study co-led by a Princeton University computer scientist: Is it possible, despite the complexity of billions of bits of genetic information and their variations between people, to develop a mechanistic model for how healthy bodies function?

«In this study, we identified a novel regulatory factor for the Golgi - ER retrograde transport and a new mechanistic connection between the physiological trafficking and the autophagic transportation of cellular material.»

«The new animal model opens the door for scientists to conduct needed mechanistic studies and identify preventative therapies to minimize this painful and debilitating condition,» Banga said.

They go on to say that «since no single broadly neutralizing antibody combines the entire range of mechanistic features anticipated to support in vivo efficacy, our study adds further evidence that combinations of such antibodies need to be considered for human application.»

So far, «genome - wide association studies» have identified variant DNA sequences showing statistical association with these and other complex diseases, but demonstrating a mechanistic role for these variants has proven elusive.

There is a clear need for further mechanistic studies to explore the role of PREX2 and mutations of PREX2 in cancer.

This study is good example of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.

Also, through these studies we solidified the mechanistic understanding for how p53 functions in the cytosol, which complements its pro-apoptotic role in the nucleus.»

Validating this original concept, we previously demonstrated that PGD - derived hES cells and their derivatives, which express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic mechanistic analysis ranging from functional studies at the cellular level to a large - scale drug screening.

Validating this concept, we previously demonstrated that human pluripotent stem cells and derivatives which, express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic analysis ranging from mechanistic studies to therapeutic screening.

Our mechanistic studies, in both mouse and human mammary cancer cells, indicate that leptin and LepR are necessary for NANOG expression.

Experimental studies of a purely phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ.

This 3D proteomics brain data can be integrated with parallel 3D transcriptomic studies to possibly provide insights to interesting targets for either therapeutic intervention or further mechanistic studies.

The discovery of CDHR3 as the probable receptor for RV - C opens the way for biological and mechanistic studies.

From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.

The results provide a valuable resource for future studies aimed at a mechanistic understanding of the function of O - GlcNAc on specific proteins during T cell activation.

Knowledge gained from mechanistic studies may contribute to the design of allogeneic vaccine - based or adoptive immunotherapy for breast cancer.

We chose to highlight a diverse set of biological processes and experimental systems to make the point that the principles of cross species analysis of basic gene function extend to the study of all human disorders, and can lead to mechanistic understanding of disease pathogenesis and rationale for the development of new therapies.

The study has earned high marks from researchers not on the soy industry's payroll, including Dan Sheehan, PhD and Daniel Doerge, PhD at the FDA's National Laboratory for Toxicological research in Jefferson, Arkansas.who stated, «Given the great difficulty in discerning the relationship between exposures and long latency adverse effects in the human population and the potential mechanistic explanation for the epidemiological findings, this is an important study.

«However, further mechanistic studies are required to investigate whether irisin could act as a protective factor for the development of cardiovascular disease and age - related disorders.

The current results provide a potential mechanistic understanding for the observed differences between Vitamin C in supplements vs food in prior studies.

For the correlative and mechanistic approaches, studies and insights from the present give rise to the assumption that the same relationships will hold in the future.

Although we have not offered mechanistic explanations for these relationships, our findings are consistent with previous studies linking a warming Arctic with extreme winter weather in NH mid-latitudes.